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Principles for Designing Scientific Investigations of Orthopedic Malignancies

  • Masanori Fukushima
Conference paper

Abstract

Chemotherapy is presently at an investigational stage, and the findings of ordinary clinical practitioners are an integral part of these investigations. Since tumors of the bone or soft tissue are rare, multi-institutional study is indispensable. One example, chemotherapy of osteosarcoma, is reviewed and principles for conducting a clinical investigation are described.

Keywords

Adjuvant Chemotherapy Clin Oncol Quality Control Process Prospective Randomized Control Study Orthopedic Oncology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rosen G, Caparros B, Huvos AG, Kosloff C, Nirenberg A, Cavavio A, Marcove R, Lane JM. Mehta B, Urban C (1982) Preoperative chemotherapy for osteogenic sarcoma: Selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to pre-operative chemotherapy. Cancer 49: 1221–1230PubMedCrossRefGoogle Scholar
  2. 2.
    Edmonson JH, Green SJ, Invins JC, Girchrist GS, Creagan ET, Pritchard DJ, Smithson WA, Dahlin DC, Taylor WF (1984) A controlled pilot study of high-dose methotrexate as postsurgical adjuvant treatment for primary osteosarcoma. J Clin Oncol 2: 152–156PubMedGoogle Scholar
  3. 3.
    Link MP, Goorin AM, Miser AW, Green A, Pratt CB, Belasco JB, Pritchard J, Malpas JS, Baker AR, Kirkpatrick JA, Ayala AG, Shuster JJ, Abelson HT, Simone JV, Vietti TJ (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. New Engl J Med 314: 16001606Google Scholar
  4. 4.
    Eilber F, Gialiano A, Eckardt J, Patterson K, Moseley S, Goodnight J (1987) Adjuvant chemotherapy for osteosarcoma: A randomized prospective trial. J Clin Oncol 5: 21–26PubMedGoogle Scholar
  5. 5.
    Winkler K, Beron G, Delling G, et al. (1988) Neoadjuvant chemotherapy of osteosarcoma: Results of a randomized cooperative trial (COSS-82) with salvage chemotherapy based on histological tumor response. J Clin Oncol 6: 329–337PubMedGoogle Scholar
  6. 6.
    Moertel GG, Thyme GS (1982) Large bowel. In: Holland JF, Frei E III (eds) Cancer medicine, 2nd edn. Lea and Febiger, Philadelphia, pp 1830–1859Google Scholar
  7. 7.
    Yamawaki S, Isu K, Ubayama Y, Takeda N, Yagi T, Usui M, Ishii S (1990) Adjuvant chemotherapy for osteosarcoma (in Japanese). Jpn J Cancer Chemother 17: 180–188Google Scholar
  8. 8.
    NIH Consensus Development Conference on Limb-Sparing Treatment of Adult Soft Tissue Sarcoma and Osteosarcoma, U.S. Department of Health and Human Services, 1985Google Scholar
  9. 9.
    Simon R, Wittes RE (1985) Methodologic guidelines for reports of clinical trials. Cancer Treat Rep 69: 1–3PubMedGoogle Scholar
  10. 10.
    Zelen M (1983) Guidelines for publishing papers on cancer clinical trials: Responsibilities of editors and authors. J Clin Oncol 1: 164–169PubMedGoogle Scholar

Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Masanori Fukushima
    • 1
  1. 1.Aichi Cancer CenterNagoya, 464Japan

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