Principles for Designing Scientific Investigations of Orthopedic Malignancies
Chemotherapy is presently at an investigational stage, and the findings of ordinary clinical practitioners are an integral part of these investigations. Since tumors of the bone or soft tissue are rare, multi-institutional study is indispensable. One example, chemotherapy of osteosarcoma, is reviewed and principles for conducting a clinical investigation are described.
KeywordsAdjuvant Chemotherapy Clin Oncol Quality Control Process Prospective Randomized Control Study Orthopedic Oncology
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