Multivariate Analysis for Histological Prognostic Factors in Soft Tissue Sarcoma of Extremities and Trunk

  • Takafumi Ueda
  • Katsuyuki Aozasa
  • Masahiko Tsujimoto
  • Akira Myoui
  • Shigeyuki Kuratsu
  • Atsumasa Uchida
  • Keiro Ono


Soft tissue sarcoma (STS) is a heterogeneous group of malignant mesenchymal tumors of which a histological grade based on the histological type could be one of the most important prognostic factors [1]. The clinicopathological staging system for STS proposed by the American Joint Committee (AJC) in 1977 utilized the histological grade as well as tumor size and extent of the tumor for staging factors [2]. However, a lack of concrete criteria for histological grading seemed to limit the value of this staging system. This might be due to discrepancies in the diagnosis and classification even among experienced pathologists because of its relative rarity and complex histology. To establish a useful grading system for STS, the prognostic significance of various histological factors were evaluated by nonparametric univariate and multivariate analysis in 169 patients with localized STS in extremities and trunk.


Histological Grade Soft Tissue Sarcoma Synovial Sarcoma Mitotic Count Tumor Depth 
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Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Takafumi Ueda
    • 1
  • Katsuyuki Aozasa
    • 2
  • Masahiko Tsujimoto
    • 3
  • Akira Myoui
  • Shigeyuki Kuratsu
    • 4
  • Atsumasa Uchida
  • Keiro Ono
    • 5
  1. 1.Department of Orthopaedic SurgeryThe Center for Adult DiseasesOsakaJapan
  2. 2.Department of PathologyNara Medical CollegeNaraJapan
  3. 3.Department of PathologyOsaka Police HospitalOsakaJapan
  4. 4.Department of PathologyOsaka University Medical SchoolOsakaJapan
  5. 5.Department of Orthopaedic SurgeryOsaka University Medical SchoolOsakaJapan

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