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Histological Typing and Grading of Adult Soft Tissue Sarcomas: Eastern Cooperative Oncology Group (ECOG) Experience and Review of the Literature

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Recent Advances in Musculoskeletal Oncology

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Abstract

Accurate histological typing of soft tissue sarcomas (STS) is a challenging task for pathologists [1–3]. Because of the significant diagnostic discordance among pathologists, the importance of histopathology peer review in the analysis of therapeutic trials has been emphasized [1, 4, 5]. Although the histological grade of malignancy (HGM) is considered to be the most important prognostic indicator, the grading system is highly complex and is not entirely reproducible [1, 6]. This report presents (1) the experience of the ECOG Pathology Review Committee with histological typing and grading of STS, including comparison of the ECOG experience with the other sarcoma study groups, (2) prognostic significance of HGM and various grading systems used by major group studies, and (3) influence of histological type and tumor grade on chemosensitivity of advanced adult STS in the ECOG trial EST 3377 [5].

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Author information

Authors and Affiliations

  1. Baystate Medical Center, Western Campus of Tufts University School of Medicine, Springfield, MA, 01199, USA

    Masanori Shiraki

  2. University of Pennsylvania School of Medicine, PA, 19104, USA

    John J. S. Brooks

Authors
  1. Masanori Shiraki
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  2. John J. S. Brooks
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Editor information

Editors and Affiliations

  1. Department of Orthopedic Surgery, Osaka University Medical School, Fukushima 1-1-50, Osaka, 553, Japan

    Atsumasa Uchida M.D.  & Keiro Ono M.D.  & 

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© 1992 Springer Japan

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Shiraki, M., Brooks, J.J.S. (1992). Histological Typing and Grading of Adult Soft Tissue Sarcomas: Eastern Cooperative Oncology Group (ECOG) Experience and Review of the Literature. In: Uchida, A., Ono, K. (eds) Recent Advances in Musculoskeletal Oncology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68364-3_28

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  • DOI: https://doi.org/10.1007/978-4-431-68364-3_28

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68366-7

  • Online ISBN: 978-4-431-68364-3

  • eBook Packages: Springer Book Archive

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