Limb-Salvage Procedures for Osteosarcoma Using Intraoperative Radiation Therapy
The survival rate of patients with osteosarcoma has been improved by advanced diagnostic techniques, the combined use of chemotherapy and radiotherapy, improved operative techniques, and integrated care systems. In the past, these patients were mainly treated by amputation combined with chemotherapy. However, in recent years, increasing advances have been made in limb salvage techniques. Since 1978, we have adopted the use of intraoperative radiation therapy (IORT) for local control of primary lesions of osteosarcoma  and of metastatic bone tumors. We describe the method of IORT, its antitumor effect, and clinical results.
KeywordsAntitumor Effect Intramedullary Nailing Limb Salvage Vastus Intermedius Metastatic Bone Tumor
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- 2.Nagashima T, Yamamuro T, Kotoura Y, Takahashi M, Abe M, Nakashima Y (1983) Histological studies of the effect of intra-operative irradiation on osteosarcoma (in Japanese). J Jpn Orthop Assoc 57: 1681–1697Google Scholar