Clinical Study of Recombinant Human Granulocyte Colony-Stimulating Factor in Patients Undergoing Intensive Chemotherapy for Malignant Bone and Soft Tissue Tumors

  • Yoshitaka Shinto
  • Atsumasa Uchida
  • Ikuo Kudawara
  • Keiro Ono
Conference paper


In intensive chemotherapy for patients with malignant bone and soft tissue tumors, bone marrow toxicity is one of the most hazardous side effects. Recently recombinant forms of four human hematopoietic colony-stimulating factors have been purified [1–3], and their potential clinical application seem to be very promising for prevention of bone marrow suppression by chemotherapy. Reports on the effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on granulocytopenia induced by chemotherapy in patients with solid tumor have been published [4–9], but these studies are still in the experimental stage. In this paper, we evaluated the efficacy and feasibility of the use of rhG-CSF for rescue of chemotherapy in malignant bone and soft tissue tumors.


Synovial Sarcoma Soft Tissue Tumor Intensive Chemotherapy Fibrous Histiocytoma Bone Marrow Toxicity 
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Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Yoshitaka Shinto
  • Atsumasa Uchida
  • Ikuo Kudawara
  • Keiro Ono
    • 1
  1. 1.Department of Orthopaedic SurgeryOsaka University Medical SchoolJapan

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