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Hepatic Transplantation and Portal Hypertension

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Book cover Portal Hypertension

Abstract

Liver transplantation has developed into a well-accepted therapeutic modality for patients with end-stage liver pathology resulting from a wide variety of different liver diseases and having quite different pathophysiologic mechanisms and highly variable natural histories [1,2]. The specific indications for liver transplantation in a given case vary widely but in general, include a pathophysiologic consequence of advanced liver disease among which the complications and consequences of portal hypertension figure prominantly. For example, advanced portal hypertension is often associated with recurrent variceal bleeding, hepatic encephalopathy, ascites formation, muscle wasting, spontaneous bacterial peritonitis, and progressive hepatic atrophy with a subsequent obligate further loss of synthetic function and the ability to regulate intermediary metabolism. Each consequence of portal hypertension can be, and often is, an immediate indication for liver transplantation. This is because each of these potential complications of portal hypertension has a profound effect upon long-term survival, quality of life, and the frequency and duration of the recurrent hospitalizations experienced by cirrhotic individuals.

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Author information

Authors and Affiliations

  1. The Departments of Medicine and Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA

    David H. Van Thiel

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  1. David H. Van Thiel
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Editors and Affiliations

  1. Department of Medicine, Chiba University Hospital, Inohana 1-8-1, Chiba, 280, Japan

    Kunio Okuda M.D., Ph.D. (Professor) (Professor)

  2. Department of Hepatology, Hopital Beaujon, 92118, Clichy, France

    Jean-Pierre Benhamou M.D. (Professor) (Professor)

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© 1991 Springer Japan

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Van Thiel, D.H. (1991). Hepatic Transplantation and Portal Hypertension. In: Okuda, K., Benhamou, JP. (eds) Portal Hypertension. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68361-2_43

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  • DOI: https://doi.org/10.1007/978-4-431-68361-2_43

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68363-6

  • Online ISBN: 978-4-431-68361-2

  • eBook Packages: Springer Book Archive

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