Hepatic Transplantation and Portal Hypertension

  • David H. Van Thiel


Liver transplantation has developed into a well-accepted therapeutic modality for patients with end-stage liver pathology resulting from a wide variety of different liver diseases and having quite different pathophysiologic mechanisms and highly variable natural histories [1,2]. The specific indications for liver transplantation in a given case vary widely but in general, include a pathophysiologic consequence of advanced liver disease among which the complications and consequences of portal hypertension figure prominantly. For example, advanced portal hypertension is often associated with recurrent variceal bleeding, hepatic encephalopathy, ascites formation, muscle wasting, spontaneous bacterial peritonitis, and progressive hepatic atrophy with a subsequent obligate further loss of synthetic function and the ability to regulate intermediary metabolism. Each consequence of portal hypertension can be, and often is, an immediate indication for liver transplantation. This is because each of these potential complications of portal hypertension has a profound effect upon long-term survival, quality of life, and the frequency and duration of the recurrent hospitalizations experienced by cirrhotic individuals.


Liver Transplantation Portal Hypertension Esophageal Varix Biliary Atresia Spontaneous Bacterial Peritonitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • David H. Van Thiel
    • 1
  1. 1.The Departments of Medicine and SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA

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