The Pathophysiology of Portal Hypertension

  • Thomas C. Mahl
  • Roberto J. Groszmann


Pressure in the portal system, as with pressure in any system, develops through an interaction of flow and resistance. A mathematical representation of this relationship is found in a modification of Ohm’s law: ΔP = Q × R, where ΔP is the pressure gradient through a system, Q is the flow in the system, and R is the resistance to that flow. It follows then, that alteration in flow or resistance leads to changes in pressure. Our present understanding suggests that established portal hypertension results from alterations in both flow and resistance. The mechanisms which provide these changes will be discussed below.


Portal Hypertension Alcoholic Liver Disease Portal Pressure Portal Blood Flow Splanchnic Blood Flow 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Thomas C. Mahl
    • 1
    • 2
  • Roberto J. Groszmann
    • 3
    • 4
  1. 1.Veterans Administration Medical CenterBuffaloUSA
  2. 2.The State University of New York at Buffalo School of MedicineBaffaloUSA
  3. 3.Veterans Administration Medical Center, HepaticHemodynamic LaboratoryWest HavenUSA
  4. 4.Yale University School of MedicineNew HavenUSA

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