Nodular Regenerative Hyperplasia, Blood Disorders and Other Uncommon Diseases Associated with Intrahepatic Portal Hypertension

  • Kamal G. Ishak


Obstruction of the flow of blood through the liver leading to portal hypertension may occur at several levels and can be caused by many different mechanisms. With some diseases the vascular blockade occurs at only one level, e. g., terminal hepatic venules (THV), sinusoids, or portal vein branches. In several diseases, however, the vascular obstruction is undoubtedly at multiple levels, and may be different in the acute or chronic stages of the same disease. For example, in alcoholic hepatitits there are lesions of THV (phlebosclerosis, venocclusive lesions), sinusoids (e. g., pericellular fibrosis and basement membrane deposition, defenestration of sinusoids) and even of portal vein branches (e. g., venocclusive lesions). Similarly, in hypervitaminosis A there is phlebosclerosis of THV, pericellular fibrosis, and hypertrophy of perisinusoidal lipocytes (Ito cells) that collectively cause portal hypertension.


Portal Hypertension Primary Biliary Cirrhosis Hereditary Hemorrhagic Telangiectasia Systemic Mastocytosis Portal Vein Branch 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Japan 1991

Authors and Affiliations

  • Kamal G. Ishak
    • 1
  1. 1.Department of Hepatic PathologyArmed Forces Institute of PathologyUSA

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