Radionuclides in Hemodynamic Investigations

  • Kunio Okuda
  • Susumu Shiomi


Radionuclides have long been utilized in the study of portal hemodynamics. Some of the early procedures were invasive, requiring puncture of the spleen or catheterization of the portal and hepatic veins, but more recent techniques are mostly noninvasive. However, the advent of realtime ultrasonography and Doppler flowmetry has largely reduced the demand for studies which use radioactive substances. The purposes of the use of radionuclides were to determine the flow speed in portal circulation, functional flow volume, relative flow volume of the arterial and portal circulation to the liver, degree and route of portal systemic shunting, etc. The reported methods and the radionuclides which were used vary, but from the practical point of view, they may be divided according to the route of administration, specifically, intravenous administration, intrasplenic injection, transcatheter administration, rectal and intestinal instillation, and combinations of these approaches. An analysis of the physicochemical properties of various radionuclides used, such as the half-life, gamma ray energy, etc., and of the counting and imaging instruments are beyond the scope of this chapter and will not be discussed here.


Portal Hypertension Hepatic Vein Hepatic Blood Flow Liver Blood Flow Portal Circulation 
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Copyright information

© Springer Japan 1991

Authors and Affiliations

  • Kunio Okuda
    • 1
  • Susumu Shiomi
    • 2
  1. 1.Department of MedicineChiba University School of MedicineChiba, 280Japan
  2. 2.Department of Medicine IIIOsaka City University Medical SchoolOsaka 545Japan

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