A Temperature Increase Abolishes Ability of Turtle Olfactory Receptors to Discriminate Odorants with Close Structures

  • Takuya Hanada
  • Makoto Kashiwayanagi
  • Kenzo Kurihara
Conference paper


The olfactory system can recognize and discriminate multifarious odorant molecules. It has been assumed that responses to odorants are induced by the binding of odorants with specific receptor proteins on olfactory receptor cells [1]. Receptor proteins in biological membranes are surrounded by lipid molecules and, hence, the perturbation of the lipid layers may affect the olfactory responses. If this is true, a temperature change in olfactory cells, which will induce a membrane fluidity change, may affect olfactory responses. In this study, we changed the temperature of the turtle olfactory epithelium by perfusing it with Ringer solutions of different temperatures and examined the effects of the temperature change on the ability of the turtle olfactory system to discriminate odors by applying a cross-adaptation method to the olfactory bulbar responses [2].


Olfactory Receptor Olfactory System Lipid Layer Odorant Receptor Isoamyl Acetate 
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  1. 1.
    Buck L, Axel R (1991) A novel multigene family may encode odorant receptors: A molecular basis for odor recognition. Cell 65: 175–187PubMedCrossRefGoogle Scholar
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    Hanada T, Kashiwayanagi M, Kurihara K (1994) A temperature increase abolishes ability of turtle olfactory receptors to discriminate odorants having similar odors. Am J Physiol (in press)Google Scholar
  3. 3.
    Nomura T, Kurihara K (1987) Liposomes as a model for olfactory cells: Changes in membrane potential in response to various odorants. Biochemistry 26: 6135–6140PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1994

Authors and Affiliations

  • Takuya Hanada
  • Makoto Kashiwayanagi
  • Kenzo Kurihara
    • 1
  1. 1.Faculty of Pharmaceutical SciencesHokkaido UniversitySapporo, 060Japan

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