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Pathology of Hepatocellular Carcinoma

  • Masamichi Kojiro
  • Toshiro Nakashima

Abstract

Primary liver cancer is divided into two major types—hepatocellular carcinoma (HCC) derived from the hapatocytes and cholangiocarcinoma from the intrahepatic bile ducts. The less common malignant epithelial tumors primary to the liver include combined hepatocellular and cholangiocarcinoma and a few others types. The description of liver cancer by Galen and Aretaeus, physicians in ancient Greece, in the second century after Christ has been cited as the oldest record of liver cancer [1]. Virchow [2] gave a detailed account of the difference between primary and metastatic liver cancer. Von Hanseman [3], who reviewed a total of 258 cases of malignant hepatic tumors at the Berlin Pathological Institute, found that the incidence of primary liver cancer was far less common than that of metastatic liver cancer in Europe. The first gross classification of primary liver cancer was proposed in 1888 by Hanot and Gilbert [4] and then by Eggel [5] in 1901. In 1911, Yamagiwa [6] and Goldzieher and Bokay [7] classified primary liver cancer histologically. Yamagiwa [6] histologically differentiated “hepatoma” arising from the hepatocyte from “cholangioma” arising from the bile duct epithelium, and his histological classification was commonly used throughout the world until quite recently. The outstanding studies in this field by Berman [1] and Edmondson and Steiner [8] form the basis for current investigations into primary liver cancer.

Keywords

Portal Vein Tumor Thrombus Primary Liver Cancer Intrahepatic Metastasis Portal Vein Tumor Thrombus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berman C (1951) Primary carcinoma of the liver. Lewis, LondonGoogle Scholar
  2. 2.
    Virchow R (1862) Krankheiten Geschwulste. Hirschwald, BerlinGoogle Scholar
  3. 3.
    Von Hansemann D (1890) Über den primare Krebs der Leber. Ber Klin Wchnschr 27:353–356Google Scholar
  4. 4.
    Hanot V, Gilbert A (1888) Études sur les maladies du foie. Asselin and Houzeau, ParisGoogle Scholar
  5. 5.
    Eggel H (1901) Über das primare Carcinom der Leber. Beitr path Anat u z allg Path 30: 506–604Google Scholar
  6. 6.
    Yamagiwa K (1911) Primäre Leber Krebs (Hepatom). Gann 5:226–282Google Scholar
  7. 7.
    Goldzieher M, Bokay Z (1911) Der primäre Leber Krebs. Virchows Arch A (Pathol Anat) 203:75–131CrossRefGoogle Scholar
  8. 8.
    Edmondson HA, Steiner, PE (1954) Primary carcinoma of the liver. A study of 100 cases among 48 900 necropsies. Cancer 7:462–503PubMedCrossRefGoogle Scholar
  9. 9.
    Szmuness W (1978) Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association. Prog Med Virol 24:40–69PubMedGoogle Scholar
  10. 10.
    Beasley RP (1982) Hepatitis B virus as the etiologic agent in hepatocellular carcinoma—epidemiologic considerations. Hepatology 2:21S–26SGoogle Scholar
  11. 11.
    Brechot C, Hadchouel M, Scotto J (1981) State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and-negative liver diseases. Proc Natl Acad Sci USA 78:3906–3910PubMedCrossRefGoogle Scholar
  12. 12.
    Shafrits D, Shouval D, Sherman HI, Hadziyannis SJ, Kew MC (1981) Integration of hepatitis B virus DNA into the genome of liver cells in chronic liver disease and hepatocellular carcinoma. N Engl J Med 305:1067–1073CrossRefGoogle Scholar
  13. 13.
    Chen DS, Hoyer BH, Nelson J, Purcell RH, Gerin SL (1982) Detection and properties of hepatitis B viral DNA in liver tissues from patients with hepatocellular carcinoma. Hepatology 2:42S–46SGoogle Scholar
  14. 14.
    Steiner PE (1960) Cancer of the liver and cirrhosis in Transaharan Africa and the United States of America. Cancer 13:1085–1166CrossRefGoogle Scholar
  15. 15.
    Okuda K, Peters RL, Simson IW (1984) Gross anatomic features of hepatocellular carcinoma from three disparate geographic areas. Proposal of new classification. Cancer 54:2165–2173PubMedCrossRefGoogle Scholar
  16. 16.
    Mori W (1956) Study on metastasis in hepatoma. Its relationship with liver cirrhosis. Tr Soc Pathol Jpn 45:224–236Google Scholar
  17. 17.
    Miyaji T, Yu K, Oda T, Nagatomo T, Sawada K (1960) Pathomorphological study on primary liver cancer in recent 10 years in Japan. Acta Hepatol Jpn 1:17–36CrossRefGoogle Scholar
  18. 18.
    Kato M, Minamisuhara T, Kiwaki M, Daima M (1957) An interesting case of hepatocellular carcinoma. J Jpn Soc Intern Med 46:1218 (Abst)Google Scholar
  19. 19.
    Arakawa M, Kage M, Isomura T, Motoyama F, Nakashima T, Kubo Y, Nakayama T (1982) Pathomorphological studies on hepatocellular carcinoma (HCC)—Seven cases of HCC with an extrahepatic tumor growth, so-called “pedunculated hepatoma”. Acta Hepatol Jpn 23:942–948CrossRefGoogle Scholar
  20. 20.
    Horie Y, Katoh S, Yoshida H, Omaoka T, Suou T, Hirayama C (1983) Pedunculated hepatocellular carcinoma. Report of three cases and review of literature. Cancer 51: 746–751PubMedCrossRefGoogle Scholar
  21. 21.
    Miyoshi M, Iwata N, Fujii H, Katake K (1977) A case of pedunculated hepatoma with spontaneous rupture. Acta Hepatol Jpn 18:765–771CrossRefGoogle Scholar
  22. 22.
    Gyotoku Y, Sugihara H, Amagasaki T, Mori I, Konoshita I (1980) An autopsy case of pedunculated liver cell carcinoma and its review. Jap J Cancer Clin 26:92–96Google Scholar
  23. 23.
    Gibson JB (1978) Histological typing of tumors of the livers, biliary tract and pancreas. International Histological Classification of Tumors. No. 20, WHO, GenevaGoogle Scholar
  24. 24.
    Buchanan TF, Huvas AG (1974) Clear cell carcinoma of the liver. Am J Clin Pathol 61: 529–539PubMedGoogle Scholar
  25. 25.
    Wu PC, Lai CL, Lam KC, Lam KC, Lok ASF, Lin HJ (1983) Clear cell carcinoma of the liver. An ultrastructural study. Cancer 52: 504–507Google Scholar
  26. 26.
    Sasaki K, Okuda K, Takahashi M (1981) Hepatic clear cell carcinoma associated with hypoglycemia and hypercholesterolemia. Cancer 47:820–822PubMedCrossRefGoogle Scholar
  27. 27.
    Peters RL (1976) Pathology of hepatocellular carcinoma. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 107–168Google Scholar
  28. 28.
    Nakanuma Y, Ohta G (1985) Is Mallory body formation a preneoplastic change? A study of 181 cases of liver bearing hepatocellular carcinoma and 82 cases of cirrhosis. Cancer 55:2400–2404PubMedCrossRefGoogle Scholar
  29. 29.
    Tomimatsu H (1983) Ultrastructural study of Mallory body in hepatocellular carcinoma. Acta Hepatol Jpn 24: 513–520CrossRefGoogle Scholar
  30. 30.
    Stromeyer FW, Ishak KG, Gerber MA, Mathew T (1980) Ground-glass cells in hepatocellular carcinoma. Am J Clin Pathol 74:254–258PubMedGoogle Scholar
  31. 31.
    Tanaka K, Toyokawa H, Uchida T, Uzawa T, Karasawa T, Shikata T, Kitano M (1977) Hepatitis B related antigens in hepatoma cells. Acta Hepatol Jpn 18:689CrossRefGoogle Scholar
  32. 32.
    Hardi CF, Ying YY, Ackerman LV, Elias JM (1980) Hepatitis B surface antigen and hepatocellular carcinoma in the People’s Republic of China. Cancer 46:1612–1616CrossRefGoogle Scholar
  33. 33.
    Nayak NC, Dhar A, Sachdeva R, Mittal A, Seth HN, Sudarsanam D, Reddy B, Wagholikar UL, Reddy CRRM (1977) Association of human hepatocellular carcinoma and cirrhosis with hepatitis B virus surface antigens in the liver. Int J Cancer 20:643–654PubMedCrossRefGoogle Scholar
  34. 34.
    Kawano Y (1983) Localization of hepatitis B surface antigen in hepatocellular carcinoma. Acta Pathol Jpn 33:1087–1093PubMedGoogle Scholar
  35. 35.
    Jaffe RH (1924) Sarcoma and carcinoma of the liver following cirrhosis. Arch Int Med 33: 330–342CrossRefGoogle Scholar
  36. 36.
    William WL, Agha FP, Morgan WS (1983) Primary sarcoma of the liver in adult. Cancer 51: 1510–1517CrossRefGoogle Scholar
  37. 37.
    Shin P, Ohmi S, Sakurai M (1981) Hepatocellular carcinoma combined with hepatic sarcoma. Acta Pathol Jpn 31:815–824PubMedGoogle Scholar
  38. 38.
    Nagamine Y, Sasaki M, Kaku K, Takahashi M (1978) Hepatic sarcoma associated with hepatoma. Acta Pathol Jpn 28:645–651PubMedGoogle Scholar
  39. 39.
    Neville E, Piyasena KHG, James DG (1975) Granulomas of the liver. Postgrad Med J 51:361–365PubMedCrossRefGoogle Scholar
  40. 40.
    Nakashima T, Kojiro M, Kawano Y, Shirai F, Takemoto N, Tomimatsu H, Kawasaki H, Okuda K (1982) Histologic growth pattern of hepatocellular carcinoma. Relationship to orcein (hepatitis B surface-antigen)-positive cells in cancer tissue. Hum Pathol 13: 563–568PubMedCrossRefGoogle Scholar
  41. 41.
    Isomura T (1979) Pathological study of primary liver cancer. Ultrastructural study of hepatocellular carcinoma—structure of blood space (tumor vessel). Acta Hepatol Jpn 20:164–174CrossRefGoogle Scholar
  42. 42.
    Sugihara S, Kojiro M, Nakashima T (1985) Ultra-structural study of hepatocellular carcinoma with replacing growth pattern. Acta Pathol Jpn 35: 549–559PubMedGoogle Scholar
  43. 43.
    Shikata T (1959) Studies on the relationship between hepatic cancer and liver cirrhosis. Acta Pathol Jpn 9:267–331Google Scholar
  44. 44.
    Geddes FW, Falkson G (1970) Malignant hepatoma in the Bantu. Cancer 25:1271–1278PubMedCrossRefGoogle Scholar
  45. 45.
    Mori W (1967) Cirrhosis and primary cancer of the liver. Comparative study in Tokyo and Cincinnati. Cancer 20: 627–631PubMedCrossRefGoogle Scholar
  46. 46.
    Lee FI (1966) Cirrhosis and hepatoma in alcoholics. Gut 7:77–95PubMedCrossRefGoogle Scholar
  47. 47.
    Nakashima T, Okuda K, Kojiro M, Sakamoto K, Kubo Y, Shimokawa Y (1975) Primary liver cancer coincident with schistosomiasis japonica. A study of 24 necropsies. Cancer 36:1483–1489PubMedCrossRefGoogle Scholar
  48. 48.
    Iuchi M, Hayakawa M, Kitani K, Yamada H, Iio M, Sasaki Y, Kameda H (1973) Hepatocellular carcinoma and chronic schistosomiasis japonica: II. Acta Hepatol Jpn 11:249–252CrossRefGoogle Scholar
  49. 49.
    Kamo E, Ebato T (1982) A clinical analysis of primary carcinoma of the liver in relation with schistosomiasis japonica. J Yamanashi Med Assoc 9:23–37Google Scholar
  50. 50.
    Edington GM (1979) Schistosomiasis and primary liver cancer. Tran R Soc Trop Med Hyg 73:351–352CrossRefGoogle Scholar
  51. 51.
    Cheever AW, Andrade ZA (1967) Pathological lesions associated with Schistosoma mansoni infection in man. Tran R Soc Trop Med Hyg 61:629–639CrossRefGoogle Scholar
  52. 52.
    Martinez-Maldonado M, Girod CE, Arellano GR, Ramirez EA (1965) Liver cell carcinoma (hepatoma) in Puerto Rico. A study of 26 cases. Am J Dig Dis 10: 522–529PubMedCrossRefGoogle Scholar
  53. 53.
    MacMahon E, Murphy AS, Bates MI (1947) Endothelial cell sarcoma of the liver following Thorotrast injection. Am J Pathol 23: 585–613PubMedGoogle Scholar
  54. 54.
    Anthony PP (1973) Primary carcinoma of the liver. A study of 282 cases in Ugandan Africans. J Pathol 110:37–48PubMedCrossRefGoogle Scholar
  55. 55.
    Sakurai M (1978) Liver cell dysplasia and hepatitis B surface and core antigens in cirrhosis and hepatocellular carcinoma of autopsy cases. Acta Pathol Jpn 28:705–719PubMedGoogle Scholar
  56. 56.
    Omata M, Mori J, Yokosuka O, Ito Y, Okuda K (1982) Hepatitis B virus antigens in liver tissue in hepatocellular carcinoma and advanced chronic liver disease—relationship to liver cell dysplasia. Liver 2:125–132PubMedCrossRefGoogle Scholar
  57. 57.
    Cohen C, Berson SD, Geddes FW (1979) Liver cell dysplasia. Association with hepatocellular carcinoma, cirrhosis and hepatitis B antigen carrier status. Cancer 44:1671–1676PubMedCrossRefGoogle Scholar
  58. 58.
    Okita K, Kodama T, Harada T, Takemoto T (1977) Early lesions and development of primary hepatocellular carcinoma in man—association with hepatitis B viral infection. Gastroenterologia Jpn 12:51–57Google Scholar
  59. 59.
    Henmi A, Uchida T, Shikata T, (1985) Karyometric analysis of liver cell dysplasia and hepatocellular carcinoma. Cancer 55:2594–2599PubMedCrossRefGoogle Scholar
  60. 60.
    Nakashima T, Kojiro M (1986) Hepatocellular Carcinoma: An Atlas of Its Pathology. Springer-Verlag, TokyoGoogle Scholar
  61. 61.
    Jimi A (1983) Pathomorphological study on hepatocellular carcinoma—a study of tumor throm-bus of the portal vein. Acta Hepatol Jpn 24:641–647CrossRefGoogle Scholar
  62. 62.
    Kojiro M, Nakahara H, Sugihara S, Murakami T, Nakashima T, Kawasaki H (1984) Hepatocellular carcinoma with intra-atrial tumor growth. A clinicopathologic study of 18 autopsy cases. Arch Pathol Lab Med 108:989–992PubMedGoogle Scholar
  63. 63.
    MacDonald RA (1957) Primary carcinoma of the liver: A clinicopathologic study of 108 cases. Arch Intern Med 99:266–279CrossRefGoogle Scholar
  64. 64.
    Kitagawa T, Sugiura G, Takazawa Y, Ohya K (1963) An autopsy case of hepatic cirrhosis associated with acute Budd-Chiari syndrome due to complicating hepatoma. Naika 12:1178–1182 (in Japanese)PubMedGoogle Scholar
  65. 65.
    Kato Y, Kurosaki Y, Kobayashi K, Sugimoto T, Takada A, Tsuda I (1971) A case of hepatocellular carcinoma with large ball-shaped tumor thrombus in the right atrium. Naika 28: 349–353 (in Japanese)PubMedGoogle Scholar
  66. 66.
    Hahne OH, Climie ARH (1962) Right atrial thrombus with ball-valve action. Am J Med 32: 942–949PubMedCrossRefGoogle Scholar
  67. 67.
    Lin TY (1976) Primary malignant tumors. In: Bockus HL (ed) Gastroenterology, Saunders, Philadelphia, pp. 522–533Google Scholar
  68. 68.
    Kojiro M, Kawabata K, Kawano Y, Shirai F, Takemoto N, Nakashima T (1982) Hepatocellular carcinoma presenting as intrabile duct tumor growth. A clinicopathologic study of 24 cases. Cancer 49:2144–2147PubMedCrossRefGoogle Scholar
  69. 69.
    Mori W (1956) Study of metastasis in hepatoma: its relation to liver cirrhosis. Tr Soc Pathol Jpn 45:224–236Google Scholar
  70. 70.
    Kawabata K (1980) Pathomorphological studies on hepatocellular carcinoma. A study of the lymph node with marked metastasis of hepatocellular carcinoma. Acta Hepatol Jpn 21:203–215CrossRefGoogle Scholar
  71. 71.
    Saitsu H, Yoshida K, Nakayama T, Okuda K, Sato M, Koga M, Sugihara S, Kojiro M (1986) Demonstration of lymphatics between tumor nodules and the regional lymph nodes in hepatocellular carcinoma. Acta Hepatol Jpn 27:1296–1302CrossRefGoogle Scholar
  72. 72.
    Allen RA, Lisa JR (1949) Combined liver cell and bile duct carcinoma. Am J Pathol 25:647–655PubMedGoogle Scholar
  73. 73.
    Goodman ZD, Ishak KG, Langloss JM, Sesterhenn IA, Rabin L (1985) Combined hepato-cellular-cholangiocellular carcinoma. A histological and immunohistological study. Cancer 55: 124–135PubMedCrossRefGoogle Scholar
  74. 74.
    Yano H, Kojiro M, Nakashima T (1986) A new human HCC cell line (KYN-1) with a transformation to adenocarcinoma. In Vitro 22:637–646Google Scholar

Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Masamichi Kojiro
  • Toshiro Nakashima
    • 1
  1. 1.The First Department of PathologyKurume University School of MedicineKurume, 830Japan

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