Pathology of Hepatocellular Carcinoma

  • Masamichi Kojiro
  • Toshiro Nakashima


Primary liver cancer is divided into two major types—hepatocellular carcinoma (HCC) derived from the hapatocytes and cholangiocarcinoma from the intrahepatic bile ducts. The less common malignant epithelial tumors primary to the liver include combined hepatocellular and cholangiocarcinoma and a few others types. The description of liver cancer by Galen and Aretaeus, physicians in ancient Greece, in the second century after Christ has been cited as the oldest record of liver cancer [1]. Virchow [2] gave a detailed account of the difference between primary and metastatic liver cancer. Von Hanseman [3], who reviewed a total of 258 cases of malignant hepatic tumors at the Berlin Pathological Institute, found that the incidence of primary liver cancer was far less common than that of metastatic liver cancer in Europe. The first gross classification of primary liver cancer was proposed in 1888 by Hanot and Gilbert [4] and then by Eggel [5] in 1901. In 1911, Yamagiwa [6] and Goldzieher and Bokay [7] classified primary liver cancer histologically. Yamagiwa [6] histologically differentiated “hepatoma” arising from the hepatocyte from “cholangioma” arising from the bile duct epithelium, and his histological classification was commonly used throughout the world until quite recently. The outstanding studies in this field by Berman [1] and Edmondson and Steiner [8] form the basis for current investigations into primary liver cancer.


Portal Vein Tumor Thrombus Primary Liver Cancer Intrahepatic Metastasis Portal Vein Tumor Thrombus 
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Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Masamichi Kojiro
  • Toshiro Nakashima
    • 1
  1. 1.The First Department of PathologyKurume University School of MedicineKurume, 830Japan

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