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Neoplasms of the Liver pp 57–70Cite as

Analysis of Proto-oncogene Expression During Liver Regeneration and Hepatocarcinogenesis

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Abstract

The discovery and characterization of viral oncogenes and the cellular genes from which they originated (cellular or proto-oncogenes) represents one of the most dramatic advances in the field of cancer research in recent years. Elucidation of the role of these genes in the process of oncogenesis and the role of the proto-oncogenes in the control of normal cellular growth and/or differentiation has united the fields of cancer research and cell biology. Despite the vast amount of information which has become available recently on the molecular nature of the alterations which lead to the “activation” of protooncogenes, the precise role of these genes in the development of natural tumors remains to be established. Some investigators have gone so far as to state that “there is as yet no convincing evidence that activated proto-oncogenes are even necessary, much less sufficient for carcinogenesis” [1]. Although this rather extreme view is a minority opinion, it is important to remember that in the complex process encompassing the development of a tumor, the oncogene may be but one player with several others remaining to be elucidated. Given this still unsettled picture, it is particularly important to define the role which various proto-oncogenes play in normal cells and tissues.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Division of Biology and Medicine, Brown University, Providence, RI, 02912, USA

    Nelson Fausto

  2. Section of Molecular, Cell and Developmental Biology, Division of Biology and Medicine, Brown University, Providence, RI, 02912, USA

    Peter R. Shank

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  1. Nelson Fausto
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  1. First Department of Medicine, Chiba University School of Medicine, Inohana, Chiba, 280, Japan

    Kunio Okuda M.D., Ph.D.

  2. Department of Hepatic Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    Kamal G. Ishak M.D., Ph.D.

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Fausto, N., Shank, P.R. (1987). Analysis of Proto-oncogene Expression During Liver Regeneration and Hepatocarcinogenesis. In: Okuda, K., Ishak, K.G. (eds) Neoplasms of the Liver. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68349-0_5

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  • DOI: https://doi.org/10.1007/978-4-431-68349-0_5

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