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Hepadna Viruses and Hepatocarcinogenesis

  • Chapter
Neoplasms of the Liver

Abstract

Since the discovery of Australian antigen, the rate of hepatitis B (HBV) infection among patients with hepatocellular carcinoma (HCC) has been studied in various parts of the world. In 1971, Tong et al. reported that 44 of 55 (88%) patients with HCC in Taiwan were positive for hepatitis B surface antigen (HBsAg) by the agar gel diffusion test [1]. Subsequently, many studies in Africa and Asia showed that the positivity rate for HBsAg varied from 35% to 90% in patients with HCC [2]. When additional serum testings for anti-HBs and anti-HBc (core) were included, HBV infection rates reached 75%–81% in Africa [3], the USA [4], and Japan [5] (Table 3.1). These data indicate that the majority of patients with HCC had a previous infection or current antigenemia.

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Authors and Affiliations

  1. First Department of Medicine, Chiba University School of Medicine, Chiba, 280, Japan

    Kunio Okuda

Authors
  1. Masao Omata
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  2. Osamu Yokosuka
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  3. Fumio Imazeki
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  4. Kunio Okuda
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Editor information

Editors and Affiliations

  1. First Department of Medicine, Chiba University School of Medicine, Inohana, Chiba, 280, Japan

    Kunio Okuda M.D., Ph.D.

  2. Department of Hepatic Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    Kamal G. Ishak M.D., Ph.D.

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© 1987 Springer Japan

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Omata, M., Yokosuka, O., Imazeki, F., Okuda, K. (1987). Hepadna Viruses and Hepatocarcinogenesis. In: Okuda, K., Ishak, K.G. (eds) Neoplasms of the Liver. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68349-0_3

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  • DOI: https://doi.org/10.1007/978-4-431-68349-0_3

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68351-3

  • Online ISBN: 978-4-431-68349-0

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