Hepadna Viruses and Hepatocarcinogenesis

  • Masao Omata
  • Osamu Yokosuka
  • Fumio Imazeki
  • Kunio Okuda


Since the discovery of Australian antigen, the rate of hepatitis B (HBV) infection among patients with hepatocellular carcinoma (HCC) has been studied in various parts of the world. In 1971, Tong et al. reported that 44 of 55 (88%) patients with HCC in Taiwan were positive for hepatitis B surface antigen (HBsAg) by the agar gel diffusion test [1]. Subsequently, many studies in Africa and Asia showed that the positivity rate for HBsAg varied from 35% to 90% in patients with HCC [2]. When additional serum testings for anti-HBs and anti-HBc (core) were included, HBV infection rates reached 75%–81% in Africa [3], the USA [4], and Japan [5] (Table 3.1). These data indicate that the majority of patients with HCC had a previous infection or current antigenemia.


Long Terminal Repeat Southern Blot Hybridization Woodchuck Hepatitis Virus Duck Hepatitis Bile Duct Adenoma 
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Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Masao Omata
  • Osamu Yokosuka
  • Fumio Imazeki
  • Kunio Okuda
    • 1
  1. 1.First Department of MedicineChiba University School of MedicineChiba, 280Japan

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