Targeting Chemotherapy of Hepatocellular Carcinoma
A number of methods utilize the feeding artery of the tumor for the treatment of hepatocellular carcinoma (HCC); such methods include implantation of an infusion pump, placement of a catheter for injection into the artery, and embolization of the artery with gelatin-gel or microspheres containing anticancer agents. However, very few methods have exploited the use of lipid as a carrier and depository of an anticancer agent. Recently, we developed a procedure in which Lipiodol ultrafluid (Lipiodol) is used as a carrier of anticancer agents for injection into the feeding artery, a significant breakthrough in the treatment of solid tumors. The lipid lymphographic agent, Lipiodol, has been found to be selectively retained in HCC when injected into the hepatic artery . In addition, a lipid contrast medium has various diagnostic applications, as described in this chapter. Anticancer agents, such as styrene maleic acid conjugates of neocarzinostatin (SMANCS) [2,3], mitomycin C (MMC), or aclarubicin (ACR), were dissolved into Lipiodol. As SMANCS/Lipiodol (LPD), MMC/LPD, ACR/LPD, or a mixture of these, these oily anticancer agents were administered by catheterization of the celiac or hepatic artery under X-ray monitor. Anticancer effects and the advantages of this targeting chemotherapy for HCC are described in the succeeding sections of this review.
KeywordsHepatic Artery Anticancer Agent Metastatic Liver Cancer Tumor Neovasculature Styrene Maleic Acid
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