Abstract
Most hepatocellular carcinomas (HCCs) develop in a liver with cirrhosis, which is unfavorable for surgical treatment. In the Far East, particularly in Japan, cirrhosis is often advanced at the time of tumor detection. The current choice of therapeutic modality is transcatheter arterial embolization (TAE), which, if properly executed in patients with moderately advanced HCC, significantly prolongs survival (Chap. 25). It does not afford complete cure, however. TAE necrotizes the arterial blood-dependent HCC, but cancer cells remain viable in the periphery of an expanding HCC, the most common gross type, and later cause intrahepatic spread.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ingold JA, Reed GB, Kaplan HS, Bagshaw MA (1965) Radiation hepatitis. Am J Roentgenol Rad Therapy 93:200–208
Johnson PM, Grossman FM, Atkins HL (1967) Radiation induced hepatic injury. Its detection by scintillation scanning. Am J Roentgenol Rad Therapy 99:435–462
Lewin K, Millis RR (1973) Human radiation hepatitis. Arch Pathol 96:21–26
Cochrane AMG, Murray-Lyon IM, Brinkley DM, Williams R (1977) Quadruple chemotherapy versus radiotherapy in treatment of primary hepa-tocellular carcinoma. Cancer 40:609–614
Bhardwaj S, Bruckner HW, Holland JF (1985) Therapy of malignant tumors of the liver. In: Berk JE (ed) Bockus gastroenterology, 4th edn., vol. 5. Saunders, Philadelphia, pp 3388–3397
Grady ED, Nolan TR, Crumbley AJ, Larose JH, Cheek WV (1975) Internal hepatic radiotherapy: II. Intra-arterial radiocolloid therapy for hepatic tumors. Am J Roentgenol Rad Therapy 124: 596–599
Grady ED (1979) Internal radiation therapy of hepatic cancer. Dis Col Rect 22:371–375
Order SE, Klein JL, Ettinger D, Alderson P, Siegelman S, Leicher P (1980) Phase I–II study of radiolabeled antibody integrated in the treatment of primary hepatic malignancies. Int J Radiation Oncol Biol Phys 6:703–710
Ettinger DS, Order SE, Wharam MD, Parker MK, Klein JL, Leicher PK (1982) Phase I–II study of isotopic immunoglobulin therapy for primary liver cancer. Cancer Treat Rep 66:289–297
Holm HH, Stryer I, Hansen H, Stadil F (1981) Ultrasonically guided percutaneous interstitial implantation of iodine 125 seeds in cancer therapy. Br J Radiol 54:665–670
Friedman M, Cassidy M, Levine M, Phillips T, Spivack S, Resser KJ (1979) Combined modality therapy of hepatic metastasis. Cancer 44:906–913
Barone RM, Byfield JE, Frankel S (1979) Combination infusional 5-fluorouracil and radiation therapy for the treatment of metastatic carcinoma of the colon to the liver. Dis Col Rect 22:376–382
Lokich J, Kinsella T, Perri J, Malcolm A, Clouse M (1981) Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy. Correlation of liver scan, liver function tests, and plasma CEA with tumor response. Cancer 48: 2569–2574
Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Morita M, Saisho H, Tsuchiya Y, Saotome N, Karasawa E, Miki M, Ueno T, Okuda K (1984) Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography. Gastroenterology 86: 495–502
Okuda K (1986) Early recognition of hepatocellular carcinoma. Hepatology 6:729–738
Ohto M, Karasawa E, Tsuchiya Y, Kimura K, Saisho H, Ono T, Okuda K (1980) Ultrasonically guided percutaneous contrast medium injection and aspiration biopsy using a real-time puncture transducer. Radiology 136:171–176
El-Domeiri AL, Huvos AG, Goldsmith HS, Foote FW Jr (1971) Primary malignant tumors of the liver. Cancer 27:7–11
Primack A, Vogel CL, Kyalwazi SK, Ziegler JL, Simon R, Anthony PP (1975) A staging system for hepatocellular carcinoma: Prognostic factors in Ugandan patients. Cancer 35:1357–1364
Steiner PE (1960) Cancer of the liver and cirrhosis in trans-Saharan Africa and the United States of America. Cancer 13:1085–1166
Okuda K, Peters RL, Simson IW (1985) Gross anatomic features of hepatocellular carcinoma from three disparate geographic areas. Proposal of new classification. Cancer 54:2164–2173
Nakashima T, Okuda K, Kojiro M, Jimi A, Yamaguchi R, Sakamoto K, Ikari T (1983) Pathology of hepatocellular carcinoma in Japan. 232 consecutive cases autopsied in ten years. Cancer 51:863–877
Shinagawa T, Ohto M, Kimura K, Tsunetomi S, Norita M, Saisho H, Tsuchiya Y, Saotome N, Karasawa E, Miki M, Ueno T, Okuda K (1984) Diagnosis and clinical features of small hepatocellular carcinoma with emphasis on the utility of real-time ultrasonography. Gastroenterology 86: 495–502
Ebara M, Ohto M, Shinagawa T, Sugiura N, Kimura K, Matsutani S, Morita M, Saisho H, Tsuchiya Y, Okuda K (1986) Natural history of minute hepatocellular carcinoma smaller than three centimenters complicating cirrhosis. A study in 22 patients. Gastroenterology 90:289–298
Okuda K (1986) Early recognition of hepatocellular carcinoma. Hepatology 6: 729–738
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Springer Japan
About this chapter
Cite this chapter
Ohto, M., Ebara, M., Yoshikawa, M., Okuda, K. (1987). Radiation Therapy and Percutaneous Ethanol Injection for the Treatment of Hepatocellular Carcinoma. In: Okuda, K., Ishak, K.G. (eds) Neoplasms of the Liver. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68349-0_26
Download citation
DOI: https://doi.org/10.1007/978-4-431-68349-0_26
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68351-3
Online ISBN: 978-4-431-68349-0
eBook Packages: Springer Book Archive