Hepatitis B Virus Infection and Hepatocellular Carcinoma

  • Harvey M. Lieberman
  • Ran Tur-Kaspa
  • David A. Shafritz


The association between persistent infection with hepatitis B virus (HBV) and the development of hepatocellular carcinoma (HCC) has been strengthened by substantial recent evidence. This evidence consists of both retrospective and prospective epidemiological studies, molecular studies of human tissue and HCC cell lines obtained from human HBV carriers who developed liver cancer, and studies of animal models infected with viruses closely related to HBV. Although the mechanism(s) by which persistent HBV infection and development of HCC are related remain largely unknown, techniques of modern molecular biology offer the means by which such answers may be obtained in the future. In this chapter, evidence supporting the association between persistent infection with HBV and the development of primary liver cancer will be examined in the hope of offering insight into the possible mechanism(s) of carcinogenesis as related to HBV infection.


Integrate Viral Sequence Integrate Hepatitis Hepadna Virus 
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Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Harvey M. Lieberman
    • 1
  • Ran Tur-Kaspa
    • 1
  • David A. Shafritz
    • 2
  1. 1.Department of Medicine, Marion Bessin Liver Research CenterAlbert Einstein College of MedicineBronxUSA
  2. 2.Department of Cell Biology, Marion Bessin Liver Research CenterAlbert Einstein College of MedicineBronxUSA

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