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Hepatitis B Virus Infection and Hepatocellular Carcinoma

  • Chapter
Neoplasms of the Liver

Abstract

The association between persistent infection with hepatitis B virus (HBV) and the development of hepatocellular carcinoma (HCC) has been strengthened by substantial recent evidence. This evidence consists of both retrospective and prospective epidemiological studies, molecular studies of human tissue and HCC cell lines obtained from human HBV carriers who developed liver cancer, and studies of animal models infected with viruses closely related to HBV. Although the mechanism(s) by which persistent HBV infection and development of HCC are related remain largely unknown, techniques of modern molecular biology offer the means by which such answers may be obtained in the future. In this chapter, evidence supporting the association between persistent infection with HBV and the development of primary liver cancer will be examined in the hope of offering insight into the possible mechanism(s) of carcinogenesis as related to HBV infection.

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Authors and Affiliations

  1. Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    Harvey M. Lieberman & Ran Tur-Kaspa

  2. Department of Cell Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    David A. Shafritz

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  1. Harvey M. Lieberman
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  2. Ran Tur-Kaspa
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  3. David A. Shafritz
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Editors and Affiliations

  1. First Department of Medicine, Chiba University School of Medicine, Inohana, Chiba, 280, Japan

    Kunio Okuda M.D., Ph.D.

  2. Department of Hepatic Pathology, Armed Forces Institute of Pathology, Washington, DC, 20306, USA

    Kamal G. Ishak M.D., Ph.D.

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© 1987 Springer Japan

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Lieberman, H.M., Tur-Kaspa, R., Shafritz, D.A. (1987). Hepatitis B Virus Infection and Hepatocellular Carcinoma. In: Okuda, K., Ishak, K.G. (eds) Neoplasms of the Liver. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68349-0_2

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  • DOI: https://doi.org/10.1007/978-4-431-68349-0_2

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