Comparative Study of the Three Nodular Lesions in Cirrhosis
A large number of livers bearing hepatocellular carcinoma (HCC) show cirrhosis , suggesting a close relationship between hepatocarcinogenesis and regenerative nodules [1–3]. Attempts to identify intermediate lesions between HCCs and regenerative nodules, particularly adenomatoid hyperplasia, have not been successful. Peters  in studying alcoholic cirrhosis with multifocal HCCs suggested that a carcinoma arises as a nodular lesion in a regenerative nodule. Anthony  reported that liver cell dysplasia, which is frequently found in liver cirrhosis associated with HCC, especially in hepatitis B surface antigen (HBsAg)-positive patients, might be a potential preneoplastic lesion. Other investigators  also proposed that iron-resistant areas within regenerative nodules have a preneoplastic significance in man as well as in experimental animals. Clustering of small dysplastic liver cells or Mallory’s body-containing cells in regenerative nodules might also have the same significance in nonalcoholics [3–5].
KeywordsRegenerative Nodule Nodular Lesion Small HCCs Reticulin Fiber Intermediate Lesion
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- 1.Peters RL (1976) Pathology of hepatocellular carcinoma. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 107–168Google Scholar
- 5.Hirota N, Hamazaki M, Williams GM (1982) Resistance to iron accumulation and presence of hepatitis B surface antigen in preneoplastic and neoplastic lesions in human hemochromatic livers. Hepato-Gastroenterol 29:49–51Google Scholar
- 7.Edmondson HA (1976) Benign epithelial tumors and tumor-like lesions of the liver. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 309–330Google Scholar
- 8.Gibson JB, Sobin H (1978) Histological typing of tumors of the liver, biliary tract and pancreas: no. 20. World Health Organization, Geneva, pp 19–25Google Scholar
- 11.Okuda K, Musha H, Nakajima Y, Kubo Y, Shimokawa Y, Nagasaki Y, Sawa Y, Jinnouchi S, Kaneko T, Obata H, Hisamatsu T, Motoike Y, Okazaki N, Kojiro M, Sakamoto K, Nakashima T (1977) Clinicopathologic features of encapsulated hepatocellular carcinoma. A study of 26 cases. Cancer 40:1240–1245PubMedCrossRefGoogle Scholar
- 12.Sano Y (1976) Histological technics: Theoretical and applied, 5th edn Nanzando, TokyoGoogle Scholar
- 14.Nakanuma Y, Kono N, Ohta G, Shirasaki S, Takeshita H, Watanabe K, Tsuda S, Yoshizawa H (1982) Pale eosinophilic inclusions simulating ground-glass appearance of cells of hepatocellular carcinoma. Acta Pathol Jap 32:71–81Google Scholar