Comparative Study of the Three Nodular Lesions in Cirrhosis

Adenomatoid Hyperplasia, Adenomatoid Hyperplasia with Intermediate Lesion, and Small Hepatocellular Carcinoma
  • Goroku Ohta
  • Yasuni Nakanuma


A large number of livers bearing hepatocellular carcinoma (HCC) show cirrhosis [1], suggesting a close relationship between hepatocarcinogenesis and regenerative nodules [1–3]. Attempts to identify intermediate lesions between HCCs and regenerative nodules, particularly adenomatoid hyperplasia, have not been successful. Peters [1] in studying alcoholic cirrhosis with multifocal HCCs suggested that a carcinoma arises as a nodular lesion in a regenerative nodule. Anthony [2] reported that liver cell dysplasia, which is frequently found in liver cirrhosis associated with HCC, especially in hepatitis B surface antigen (HBsAg)-positive patients, might be a potential preneoplastic lesion. Other investigators [4] also proposed that iron-resistant areas within regenerative nodules have a preneoplastic significance in man as well as in experimental animals. Clustering of small dysplastic liver cells or Mallory’s body-containing cells in regenerative nodules might also have the same significance in nonalcoholics [3–5].


Regenerative Nodule Nodular Lesion Small HCCs Reticulin Fiber Intermediate Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Peters RL (1976) Pathology of hepatocellular carcinoma. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 107–168Google Scholar
  2. 2.
    Anthony PP (1976) Precursor lesions for liver cancer in humans. Cancer Res 36:2579–2583PubMedGoogle Scholar
  3. 3.
    Nakanuma Y, Ohta G (1985) Is Mallory body formation a pre-neoplastic change? A study of 181 cases of liver bearing hepatocellular carcinoma and 92 cases of cirrhosis. Cancer 55:2400–2405PubMedCrossRefGoogle Scholar
  4. 4.
    Watanabe S, Okita K, Harada T, Kodama T, Numa Y, Takemoto T, Takahashi T (1983) Morphologic studies of the liver cell dysplasia. Cancer 51:2197–2205PubMedCrossRefGoogle Scholar
  5. 5.
    Hirota N, Hamazaki M, Williams GM (1982) Resistance to iron accumulation and presence of hepatitis B surface antigen in preneoplastic and neoplastic lesions in human hemochromatic livers. Hepato-Gastroenterol 29:49–51Google Scholar
  6. 6.
    Arakawa M, Sugihara S, Kenmochi K, Kage M, Nakashima T, Nakayama T, Tashiro S, Hiraoka T, Suenaga M, Okuda K (1986) Transition from benign adenomatous hyperplasia to hepatocellular carcinoma? J Gastroenterol Hepatol 1:3–14CrossRefGoogle Scholar
  7. 7.
    Edmondson HA (1976) Benign epithelial tumors and tumor-like lesions of the liver. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 309–330Google Scholar
  8. 8.
    Gibson JB, Sobin H (1978) Histological typing of tumors of the liver, biliary tract and pancreas: no. 20. World Health Organization, Geneva, pp 19–25Google Scholar
  9. 9.
    Edmondson HA, Steiner PE (1954) Primary carcinoma of the liver: study of 100 cases among 48,700 necropsies. Cancer 7:462–503PubMedCrossRefGoogle Scholar
  10. 10.
    Nakashima T, Kojiro M, Kawano Y, Shirai F, Takemoto N, Tomimatsu H, Kawasaki H, Okuda H (1982) Histologic growth pattern of hepatocellular carcinoma: relationship to orcein (hepatitis B surface antigen)-positive cells in cancer tissue. Hum Pathol 13: 563–568PubMedCrossRefGoogle Scholar
  11. 11.
    Okuda K, Musha H, Nakajima Y, Kubo Y, Shimokawa Y, Nagasaki Y, Sawa Y, Jinnouchi S, Kaneko T, Obata H, Hisamatsu T, Motoike Y, Okazaki N, Kojiro M, Sakamoto K, Nakashima T (1977) Clinicopathologic features of encapsulated hepatocellular carcinoma. A study of 26 cases. Cancer 40:1240–1245PubMedCrossRefGoogle Scholar
  12. 12.
    Sano Y (1976) Histological technics: Theoretical and applied, 5th edn Nanzando, TokyoGoogle Scholar
  13. 13.
    Popper H (1977) Pathologic aspects of cirrhosis— a review. Am J Pathol 87:228–264PubMedGoogle Scholar
  14. 14.
    Nakanuma Y, Kono N, Ohta G, Shirasaki S, Takeshita H, Watanabe K, Tsuda S, Yoshizawa H (1982) Pale eosinophilic inclusions simulating ground-glass appearance of cells of hepatocellular carcinoma. Acta Pathol Jap 32:71–81Google Scholar
  15. 15.
    Anthony PP (1975) Hepatoma associated with androgenic steroids. Lancet 1:685–686PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Goroku Ohta
  • Yasuni Nakanuma
    • 1
  1. 1.Second Department of PathologyKanazawa University School of MedicineKanazawa, 920Japan

Personalised recommendations