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Malignant Mesenchymal Tumors of the Liver

  • Kamal G. Ishak

Abstract

Primary malignant mesenchymal tumors of the liver are much rarer than epithelial neoplasms, but figures regarding their incidence are quite limited. Of the 405 primary malignant tumors collected by Edmondson and Peters [1] 1.2% were sarcomas. A survey of death certificates, notoriously unreliable, in the United States from 1966 to 1973 disclosed 205 hepatic sarcomas [2]; the cases included angiosarcoma (36%), leiomyosarcoma (12%), fibrosarcoma (7%), and unspecified sarcomas (44%).

Keywords

Vinyl Chloride Acquire Immune Deficiency Syndrome Arch Pathol Histiocytic Sarcoma Embryonal Rhabdomyosarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Edmondson HA, Peters RL (1982) Neoplasms of the liver. In: Schiff L, Schiff ER (eds) Diseases of the liver, 5th edn. Lippincott, Philadelphia, pp 1101–1157Google Scholar
  2. 2.
    Falk H, Herbert J, Crouley S (1981) Epidemiology of hepatic angiosarcoma in the United States: 1964–1974. Environ Hlth Persp 41:107–113Google Scholar
  3. 3.
    Shin P, Ohmi S, Sakurai M (1981) Hepatocellular carcinoma combined with hepatic sarcoma. Acta Pathol Jpn 31:815–824PubMedGoogle Scholar
  4. 4.
    Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer FW (1984) Epithelioid hemangioendothelioma of the liver: A clinicopathologic and follow-up study of 32 cases. Hum Pathol 15:839–852PubMedGoogle Scholar
  5. 5.
    Ishak KG, Sesterhenn IA, Goodman ZD, Rabin L, Stromeyer (1985) Hepatic epithelioid hemangioendothelioma. In: Brunner H, Thaler H (eds) Hepatology: A Festschrift for Hans Popper. Raven, New York, pp 183–189Google Scholar
  6. 6.
    Dail DH, Liebow AA, Gmelich JT, Friedman PJ, Miyai K, Myer W, Patterson SD, Hannar SP (1983) Intravascular, bronchiolar and alveolar tumor of the lung: An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 51:452–464PubMedGoogle Scholar
  7. 7.
    Weiss SW, Enzinger FM (1982) Epithelioid hemangioendothelioma: A Vascular tumor often mistaken for a carcinoma. Cancer 50:970–981PubMedGoogle Scholar
  8. 8.
    Ellis GL, Kratichvil FJ (1986) Epithelioid hemangioendothelioma of the head and neck: A clinicopathologic report of twelve cases. Oral Surg, Oral Med, Oral Pathol 61:61068Google Scholar
  9. 9.
    Weiss SW, Ishak KG, Dail DH, Sweet DE, Enzinger FM (1986) Epithelioid hemangioendothelioma and related lesions. Diagnositc Histopathol 3:259–287Google Scholar
  10. 10.
    Fukayama M, Nihei Z, Takizawa T, Kawaguchi K, Harada H, Koike M (1984) Malignant epithelioid hemangioendothelioma of the liver, spreading through the hepatic veins. Virch Arch (Pathol Anat) 404:275–287Google Scholar
  11. 11.
    Dean PJ, Haggitt RC, O’Hara CJ (1985) Malignant epithelioid hemangioendothelioma of the liver in young women: Relationship to oral contraceptive use. Am J Surg Pathol 9:695–704PubMedGoogle Scholar
  12. 12.
    Clements D, Hubscher S, West R, Elias E, McMaster P (1986) Epithelioid hemangioendothelioma: A case report. J Hepatol 2:441–449PubMedGoogle Scholar
  13. 13.
    Anonymous (1981) Angiosarcoma of the liver: A growing problem? Br Med J 282: 504–505Google Scholar
  14. 14.
    Locker GY, Doroshow JH, Zwelling LA, Chabner BA (1979) The clinical features of hepatic angiosarcoma: A report of four cases and a review of the English Literature. Medicine 58:48–64PubMedGoogle Scholar
  15. 15.
    Ishak KG (1976) Mesenchymal tumors of the liver. In: Okuda K, Peters RL (eds) Hepatocellular carcinoma. Wiley, New York, pp 247–307Google Scholar
  16. 16.
    Truell JE, Peck SD, Reiquam CW (1973) Hemangiosarcoma of the liver complicated by disseminated intravascular coagulation: A case report. Gastroenterology 65:936–942PubMedGoogle Scholar
  17. 17.
    Levy DW, Rindsberg S, Friedman AC, Fishman EK, Ros PR, Radecki PD, Siegelman SS, Goodman ZD, Pyatt RS, Grumbach K (1986) Thorotrast-induced hepatosplenic neoplasia: CT identification. AJR 146:997–1004PubMedGoogle Scholar
  18. 18.
    Mahony B, Jeffrey RM, Federle MP (1982) Spontaneous rupture of hepatic and splenic angiosarcoma demonstrated by CT. AJR 138: 965–966PubMedGoogle Scholar
  19. 19.
    Van Kaick G, Siegert A, Luhrs H, Lieberman D (1986) Der Beitrag der Computertomographie zur Qunatifizierung der Thorotrastose und zur thorotrastinduzierter Lebertumoren. Radiologe 26:123–128PubMedGoogle Scholar
  20. 20.
    Dannaher CL, Tamburro CL, Yam LT (1981) Occupational carcinogenesis: The Louisville experience with vinyl chloride-associated hepatic angiosarcoma. Am J Med 70:279–287PubMedGoogle Scholar
  21. 21.
    Fortwengler HP, Jones D, Espinosa E, Tamburro CL (1981) Evidence for endothelial cell origin of vinyl chloride-induced hepatic angiosarcoma. Gastroenterology 80:1415–1419PubMedGoogle Scholar
  22. 22.
    Manning JT, Ordonez NG, Barton JH (1983) Endothelial cell origin of thorium oxide-induced angiosarcoma of liver. Arch Pathol Lab Med 107:456–458PubMedGoogle Scholar
  23. 23.
    Kojiro M, Nakashima T, Ito Y, Ikezaki H, Moni T, Kido C (1985) Thorium dioxide-related angiosarcoma of the liver: Pathomorphologic study of 29 autopsy cases. Arch Pathol Lab Med 109:853–857PubMedGoogle Scholar
  24. 24.
    Miettinen M, Holhofer H, Lehto V-P, Miettinen A, Virtanen I (1983) Ulex europaeus 1 lectin as a marker for tumors derived from endothelial cells. Am J Clin Pathol 79:32–36PubMedGoogle Scholar
  25. 25.
    Telles NC, Thomas LB, Popper H, Ishak KG Falk H (1979) Evolution of Thorotrast-induced hepatic angiosarcomas. Environ Res 18:74–78PubMedGoogle Scholar
  26. 26.
    Thomas LB, Popper H, Berk PD, Selikoff I, Falk H (1975) Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti’s syndrome) to angiosarcomas. N Engl Med 292: 17–22Google Scholar
  27. 27.
    Berk PD, Martin JF, Young RS, Creech J, Selikoff IJ, Falk H, Watanabe P, Popper H, Thomas L (1976) Vinyl chloride-associated liver disease. Ann Intern Med 84:717–731PubMedGoogle Scholar
  28. 28.
    Popper H, Thomas LB, Teller NC, Falk H, Selikoff IJ (1978) Development of hepatic angiosarcoma induced by vinyl chloride, Thorotrast and arsenic: Comparison with cases of unknown etiology. Am J Pathol 92:349–376PubMedGoogle Scholar
  29. 29.
    Tamburro CH, Makk L, Popper H (1984) Early hepatic histologic alterations among chemical (vinyl monomer) workers. Hepatology 4:413–418PubMedGoogle Scholar
  30. 30.
    Popper H, Maltoni C, Selikoff IJ (1980) Vinyl chloride-induced hepatic lesions in man and rodents. A comparison. Liver 1:7–20Google Scholar
  31. 31.
    Gedigk P, Muller R, Bechtelsheimer H (1975) Morphology of liver damage among polyvinyl chloride production workers: A report of 51 cases. Ann NY Acad Sci 246:278–285PubMedGoogle Scholar
  32. 32.
    Schattenberg PJ, Totovic V, Gedigk P, Marsteller HJ (1977) Die Ultrastruktur der Leberschädigung bei der chronischen Vinylchlorid-Intoxikation. Virch Arch (Pathol Anat) 373: 233–247Google Scholar
  33. 33.
    Terzakis JH, Sommers SC, Snyder RW, Sabbath M (1974) X-ray microanalysis of hepatic thorium depositions. Arch Pathol 98:241–242PubMedGoogle Scholar
  34. 34.
    Bowen JH, Woodward BH, Mossier JA, Ingram P, Shelburne JD (1980) Energy dispersive X-ray detection of thorium dioxide. Arch Pathol Lab Med 104:459–461PubMedGoogle Scholar
  35. 35.
    Irie H, Mori W (1984) Long term effects of thorium dioxide (Thorotrast) administration on human liver: Ultrastructural localization of thorium dioxide in human liver by analytical electron microscopy (1984) Acta Pathol Jpn 34:221–228PubMedGoogle Scholar
  36. 36.
    Ishak KG (1986) Applications of scanning electron microscopy to the study of liver disease. Prog Liver Dis 8:1–32PubMedGoogle Scholar
  37. 37.
    Falk H, Telles NC, Ishak KG, Thomas LB, Popper H (1979) Epidemiology of Thorotrastinduced hepatic angiosarcoma in the united States. Environ Res 18:65–73PubMedGoogle Scholar
  38. 38.
    Da Motta CL, Da Silva Horta J, Tavares MH (1979) Prospective epidemiological study of Thorotrast-exposed patients in Portugal. Environ Res 18:152–173PubMedGoogle Scholar
  39. 39.
    Baxter PJ, Langlands AO, Anthony PP, Mac-Sween RNM, Scheuer PJ (1980) Angiosarcoma of the liver: A marker tumour for the late effects of Thorotrast in Great Britain. Br J Cancer 41: 446–452PubMedGoogle Scholar
  40. 40.
    Van Kaick G, Muth H, Kaul A, Immich H, Lieberman D, Lorenz D, Lorenz WJ, Luhrs H, Scheer KE, Wagner G, Wegener K, Wesch H (1984) Results of the German Thorotrast study. Prog Cancer Res 26:253–262Google Scholar
  41. 41.
    Yamada S, Hosoda S, Tateno H, Kido C, Takahashi S (1983) Survey of Thorotrast-associated liver cancers in Japan. J Natl Cancer Inst 70: 31–35PubMedGoogle Scholar
  42. 42.
    Ross JM (1932) A case illustrating the effects of prolonged action of radium. J Pathol Bacteriol 35:899–912Google Scholar
  43. 43.
    Miyake S, Onoue K, Ueda M, Kohno H, Araki F, Iwasaki K (1982) Clinical studies on two cases of hepatic angiosarcoma. Acta Hepatol Jap 23: 1326–1333Google Scholar
  44. 44.
    Falk H, Creech JL, Heath CW, Johnson MN, Key MM (1974) Hepatic disease among workers at a vinyl chloride polymerization plant. JAMA 230: 59–63PubMedGoogle Scholar
  45. 45.
    Pialat J, Pasquier B, Pahn M, Kopp N (1979) Pathologie hépatique du chlorure de vinyle monomère (CVM): Huit observations anatomocliniques personnelles. Arch Anat Cytol Pathol 27:361–375PubMedGoogle Scholar
  46. 46.
    Forman D, Bennett B, Stafford J, Doll R (1985) Exposure to vinyl chloride and angiosarcoma of the liver: A report of the register of cases. Br J Ind Med 42:750–753PubMedGoogle Scholar
  47. 47.
    Roth F (1957) The sequelae of chronic arsenic poisoning in Moselle vintners. Ger Med Mon 2:211–217Google Scholar
  48. 48.
    Regelson W, Kim U, Ospina J, Holland JF (1968) Hemangioendothelial sarcoma of the liver from chronic arsenic introxication by Fowler’s solution. Cancer 21: 514–522PubMedGoogle Scholar
  49. 49.
    Rennke H, Prat GA, Etcheverry RB, Katz RU, Donoso S (1971) Hemangioendothelioma maligno del higado y arsenicismo chronica. Rev Med Chil 99:664–668PubMedGoogle Scholar
  50. 50.
    Lander JJ, Stanley RJ, Sumner HW, Boswell D, Asch RD (1975) Angiosarcoma of the liver associated with Fowler’s solution. Gastroenterology 68:1582–1586PubMedGoogle Scholar
  51. 51.
    Brady J, Liberatore F, Harper P, Greenwald P, Burnett W, Davies JNP, Bishop M, Polan A, Vianna N (1977) Angiosarcoma of the liver: An epidemiologic study. J Natl Cancer Inst 59: 1383–1385PubMedGoogle Scholar
  52. 52.
    Falk H, Herbert JT, Edmonds L, Heath CW, Thomas LB, Popper H (1981) Review of four cases of childhood hepatic angiosarcomaelevated environmental arsenic exposure in one case. Cancer 47:382–391PubMedGoogle Scholar
  53. 53.
    Falk H, Caldwell GG, Ishak KG, Thomas LB, Popper H (1981) Arsenic-related hepatic angiosarcoma. Am J Ind Med 2:43–50PubMedGoogle Scholar
  54. 54.
    Roat JW, Wald A, Mendelow H, Pataki KG (1982) Hepatic angiosarcoma associated with short-term arsenic ingestion. Am J Med 73: 933–936PubMedGoogle Scholar
  55. 55.
    Kasper ML, Schoenfield L, Strom RL, Theologides A (1984) Hepatic angiosarcoma and bronchioloalveolar carcinoma induced by Fowler’s solution. JAMA 252:3407–3408PubMedGoogle Scholar
  56. 56.
    Pimentel JC, Menezes AP (1977) Liver disease in vineyard sprayers. Gastroenterology 72:275–283PubMedGoogle Scholar
  57. 57.
    Baker HC, Paget GE, Davson J (1956) Haemangioendothelioma of the liver. J Pathol Bacteriol 72:173–182PubMedGoogle Scholar
  58. 58.
    Kwittken J, Tartow LR (1966) Haemochromatosis and Kupffer cell sarcoma with unusual localization of iron. J Pathol Bacteriol 92: 571–573PubMedGoogle Scholar
  59. 59.
    Sussman EB, Nydick I, Gray G (1974) Hemangioendothelial sarcoma of the liver and hemochromatosis. Arch Pathol 97:39–42PubMedGoogle Scholar
  60. 60.
    Falk H, Thomas LB, Popper H, Ishak KG (1979) Hepatic angiosarcoma associated with androgenic-anabolic steroids. Lancet 2:1120–1123PubMedGoogle Scholar
  61. 61.
    Nordsten M (1985) Hemangiosarcoma hepatis associeret med brug of androgene steroider. Ugeskr Laeger 147:2615–2616PubMedGoogle Scholar
  62. 62.
    Shi ECP, Fischer A, Crouch R, Ham JM (1981) Possible association of angiosarcoma with oral contraceptive agents. Med J Aust 1:473–474PubMedGoogle Scholar
  63. 63.
    Hoch-Ligeti C (1978) Angiosarcoma of the liver associated with diethylstilbesterol. JAMA 240: 1510–1511PubMedGoogle Scholar
  64. 64.
    Daneshmend TK, Scott GL, Bradfield JWB (1979) Angiosarcoma of liver associated with phenelzine. BrM J6.1679Google Scholar
  65. 65.
    Kirchner SG, Heller RM, Kasselberg AG, Greene HL (1981) Infantile hemangioendothelioma with subsequent malignant degeneration. Pediatr Radiol 11:42–45PubMedGoogle Scholar
  66. 66.
    Strate SM, Rutledge JC, Weinberg AG (1984) Delayed development of angiosarcoma in multinodular infantile hepatic hemangioendothelioma. Arch Pathol Lab Med 108:943–944PubMedGoogle Scholar
  67. 67.
    Noronha R, Gonzalez-Crussi F (1984) Hepatic angiosarcoma in childhood: A case report and review of the literature. Am J Surg Pathol 8: 863–871PubMedGoogle Scholar
  68. 68.
    Alt B, Hafez GR, Trigg M, Shahidi N, Gilbert EF (1985) Angiosarcoma of the liver and spleen in an infant. Ped Pathol 4:331–339Google Scholar
  69. 69.
    Dehner LP, Ishak KG (1971) Vascular tumors of the liver in infants and children. Arch Pathol Lab Med 92:101–111Google Scholar
  70. 70.
    Bertrand L, Puyeo J, Pages A, Ciurana AJ, Blanc F, Kitschke B (1980) Hemangiosarcoma du foie secondaire a un angiome caverneux calcifié: Mort en coagulopathie de consommation. Ann Gastroenterol Hépatol 18:19–27Google Scholar
  71. 71.
    Winberg CD, Ranchod M (1979) Thorotrast induced hepatic cholangiocarcinoma and angiosarcoma. Hum Pathol 10:108–112PubMedGoogle Scholar
  72. 72.
    Wegener K, Leipolz-Angermuller S (1979) Double tumors of the liver following intravenous Thorotrast injection: Patho-anatomic report on two cases. Virch Arch (Pathol Anat) 382:63–71Google Scholar
  73. 73.
    Kojiro M, Kawano Y, Kawasaki H, Nakashima T, Ikezaki H (1982) Thorotrast-induced hepatic angiosarcoma, and combined hepatocellular and cholangiocarcinoma in a single patient. Cancer 49:2161–2164PubMedGoogle Scholar
  74. 74.
    Sakai K, Shiina M, Ishihara N, Kato Y (1984) Thorotrast-induced multiple primary malignant tumors of the liver—cholangiocarcinoma and malignant hemangioendothelioma. Jpn Clin Oncol 14:411–416Google Scholar
  75. 75.
    Delorme FC (1978) Association d’un angiosarcome du foie et d’un hépatome, chez un ouvrier du chlorure de vinyle. Ann Anat Pathol 23: 105–113Google Scholar
  76. 76.
    Leu HJ, Odermatt B (1985) Multicentric angiosarcoma (Kaposi’s sarcoma): Light and electron microscopic and immunohistological findings of idiopathic cases in Europe and Africa and of cases associated with AIDS. Virch Arch (Pathol Anat) 408:29–41Google Scholar
  77. 77.
    Reichert CM, O’Leary TJ, Levens DL (1983) Autopsy pathology in the acquired immune deficiency syndrome. Am J Pathol 112:357–382PubMedGoogle Scholar
  78. 78.
    Welch K, Finkbeiner W, Alpers CE (1984) Autopsy findings in the acquired immune deficiency syndrome. JAMA 252:1152–1159PubMedGoogle Scholar
  79. 79.
    Guarda LA, Luna MA, Smith IL (1984) Acquired immune deficiency syndrome: Postmortem findings. Am J Clin Pathol 81: 549–557PubMedGoogle Scholar
  80. 80.
    Niedt G, Schinella RA (1985) Acquired immunodeficiency syndrome: Clinicopathologic study of 56 autopsies. Arch Pathol Lab Med 109:727–734PubMedGoogle Scholar
  81. 81.
    Bendelac A, Kenitakis J, Chouvet B, Viac J, Thivolet J (1985) Sarcome de Kaposi: Étude immunohistochimique comparative et intérêt his-togénétique des marqueurs endothéliaux. Ann Pathol 5:45–52PubMedGoogle Scholar
  82. 82.
    Beckstead JH, Wood GS, Fletcher V (1985) Evidence for the origin of Kaposi’s sarcoma from lymphatic endothelium. Lab Invest 52:6AGoogle Scholar
  83. 83.
    Bartal AH, Lichtig C, Friedman-Birnbaum R, Avraham Z, Spivak N, Fass B, Feit C, Robinson E, Hirshaut Y (1985) The interaction of Kaposi’s sarcoma with monoclonal antibodies to human sarcoma and connective tissue differentiation antigens. Cancer 56:1071–1074PubMedGoogle Scholar
  84. 84.
    Davis GL, Kissane JM, Ishak KG (1969) Embryonal rhabdomyosarcoma (sarcoma botry-oides) of the biliary tree. Cancer 24:333–342PubMedGoogle Scholar
  85. 85.
    Mori H, Matsubara N, Fuji M (1979) Alphafetoprotein producing rhabdomyosarcoma of the adult liver. Acta Pathol Jap 29:485–491Google Scholar
  86. 86.
    Lack EE, Perez-Atayada AR, Schuster SR (1981) Botryoid rhabdomyosarcoma of the biliary tract: Report of five cases with ultrastructural observations and literature review. Am J Surg Pathol 5:643–652PubMedGoogle Scholar
  87. 87.
    Ruymann FB, Raney B, Crist WM, Lawrence W, Lindberg RD, Soule EH (1985) Rhabdomyosarcoma of the biliary tree in childhood: A report from the intergroup rhabdomyosarcoma study. Cancer 56: 575–581PubMedGoogle Scholar
  88. 88.
    Aldabagh SM, Shibata CS, Taxy JB (1986) Rhabdomyosarcoma of the common bile duct in an adult. Arch Pathol Lab Med 110: 547–550PubMedGoogle Scholar
  89. 89.
    Morimoto H, Takade Y, Akita T, Kato Y, Tanigawa N, Muraoka R, Urata Y (1986) A resected case of the collision tumor of hepatocellular carcinoma and primary liver rhabdomyosarcoma. J Jpn Surg Soc 87:456–463Google Scholar
  90. 90.
    Cannon PM, Legge DA, O’Donnell B (1979) The use of percutaneous transhepatic cholangio-graphy in case of embryonal rhabdomyosarcoma. Br J Radio 52:326–327Google Scholar
  91. 91.
    Brooks JJ (1982) Immunochemistry of soft tissue tumors: Myoglobin as a tumor marker for rhabdomyosarcoma. Cancer 50:1757–1783PubMedGoogle Scholar
  92. 92.
    Tsokos M (1986) The role of immunocyto-chemistry in the diagnosis of rhabdomyosarcoma. Arch Pathol Lab Med 110:776–778PubMedGoogle Scholar
  93. 93.
    Scupham R, Gilbert EF, Wilde J, Wiedrich TA (1986) Immunohistochemical studies of rhabdomyosarcoma. Arch Pathol Lab Med 110: 818–821PubMedGoogle Scholar
  94. 94.
    Stocker JT, Ishak KG (1978) Undifferentiated embryonal sarcoma of the liver. Cancer 42: 336–348PubMedGoogle Scholar
  95. 95.
    Stanley RJ, Dehner LP, Hesker AE, (1973) Primary malignant mesenchymal tumors (mesenchymoma) of the liver in childhood. Cancer 32: 973–984PubMedGoogle Scholar
  96. 96.
    Cozzutto C, De Bernardi B, Comelli A, Soave F (1981) Malignant mesenchymoma of the liver in children: A clinicopathologic and ultrastructural study. Hum Pathol 12:481–485PubMedGoogle Scholar
  97. 97.
    Sumiyoshi A, Nicho Y (1971) Primary osteo-genic sarcoma of the liver: Report of an autopsy case. Acta Pathol Jpn 21: 305–312PubMedGoogle Scholar
  98. 98.
    Lagacé R, Delage C, Robert J (1974) Le mésenchymome primitif du foie: Étude ultrastructural. Ann Anat Pathol 19:275–286Google Scholar
  99. 99.
    Gonzalez-Crussi F (1983) Undifferentiated (embryonal) liver sarcoma of childhood: Evidence of leiomyoblastic differentiation. Ped. Pathol 1: 281–290Google Scholar
  100. 100.
    Gallivan MVE, Lack EE, Chun B, Ishak KG (1983) Undifferentiated (“embryonal”) sarcoma of the liver: Ultrastructure of a case presenting as a primary intracardiac tumor. Ped Pathol 1: 291–300Google Scholar
  101. 101.
    Pieterse AS, Smith M, Smith LA, Smith P (1985) Embryonal (undifferentiated) sarcoma of the liver: Fine-needle aspiration cytology and ultrastructural findings. Arch Pathol Lab Med 109: 677–680PubMedGoogle Scholar
  102. 102.
    Weinberg AG, Finegold MJ (1983) Primary hepatic tumors of childhood. Hum Pathol 14: 512–537PubMedGoogle Scholar
  103. 103.
    Ros PR, Olmstead WW, Dachman AH, Goodman ZD, Ishak KG, Hartman DS (1986) Undifferentiated (embryonal) sarcoma of the liver: Radiologic-pathologic correlation. Radiology 161:141–145PubMedGoogle Scholar
  104. 104.
    Esposito R, Pollavini G, de Lalla F (1976) A case of primary undifferentiated sarcoma of the liver diagnosed by peritoneoscopy and guided biopsy. Endoscopy 8:108–110Google Scholar
  105. 105.
    Smithson WA, Telander RL, Carney JA (1982) Mesenchymoma of the liver in childhood: Five-year survival after combined modality treatment. J Ped Surgery 17:70–72Google Scholar
  106. 106.
    Harris MB, Shen S, Weiner MA, Bruckner JG, Dasgupta I, Bleicher M, Fortner H, Deleiko NS, Becker N, Rose J, Käsen L (1984) Treatment of primary undifferentiated sarcoma of the liver with surgery and chemotherapy. Cancer 54: 2859–2862PubMedGoogle Scholar
  107. 107.
    Tanner AR, Bolton PM, Powell LW (1978) Primary sarcoma of the liver: Report of a case with excellent response to hepatic artery ligation and infusion chemotherapy. Gastroenterology 74: 121–123PubMedGoogle Scholar
  108. 108.
    Abramowsky CR, Cebelin M, Choudhury A, Izant RJ (1980) Undifferentiated (embryonal) sarcoma of the liver with alphi-antitrypsin deposits: Immunohistochemical and ultrastructural structural studies. Cancer 45:3108–3113PubMedGoogle Scholar
  109. 109.
    Ellis IO, Cotton RE (1983) Primary malignant mesenchymal tumor of the liver in an elderly female. Histopathology 7:113–121PubMedGoogle Scholar
  110. 110.
    Keating S, Taylor GP (1985) Undifferentiated (embryonal) sarcoma of the liver: Ultrastructural and immunohistochemical similarities with malignant fibrous histiocytoma. Hum Pathol 16: 693–699PubMedGoogle Scholar
  111. 111.
    Blattner WA, Henson DE, Young RC, Fraumeni JF (1977) Malignant mesenchymoma and birth defects: Prenatal exposure to phenytoin. JAMA 238:334–335PubMedGoogle Scholar
  112. 112.
    Shallow TA, Wanger FB (1947) Primary fibrosarcoma of the liver. Ann Surg 125:439–446PubMedGoogle Scholar
  113. 113.
    Simpson HM, Baggenstoss AH, Stauffer MH (1955) Primary sarcoma of the liver: A report of three cases. South Med J 48:1177–1182PubMedGoogle Scholar
  114. 114.
    Snapper I, Schraft WC, Ginsberg DM (1964) Severe hypoglycemia due to fibrosarcoma of the liver. Maendschr Kindergenees 32:337–347Google Scholar
  115. 115.
    Ojima A, Sugiyama T, Takeda J (1964) Six cases of rare malignant tumors of the liver. Acta PatholJpn 14:95–102Google Scholar
  116. 116.
    Totzke HA, Hutcheson JB (1965) Primary fibrosarcoma of the liver. South Med J 58:236–238PubMedGoogle Scholar
  117. 117.
    Balouet G, Destombes P (1967) À propos de quelques tumeurs mesenchymateuses hépatiques d’apparence primitive. Ann Anat Pathol 12: 273–286Google Scholar
  118. 118.
    Cavallo T, Lichewitz B Rozov T (1968) Primary fibrosarcoma of the liver: Report of a case. Rev Hosp Clin Med Sao Paulo 23:44–69Google Scholar
  119. 119.
    Smith D, Rele SR (1972) A case of primary fibrosarcoma of the liver. Postgrad Med J 48:62–63PubMedGoogle Scholar
  120. 120.
    Walter VE, Bodner E, Lederer B (1972) Primäres Fibrosarkom der Leber. Wieh Klin Wochenschr 84:808–810Google Scholar
  121. 121.
    Alrenga DP (1974) Primary fibrosarcoma of the liver: Case report and review of the literature. Cancer 36:446–449Google Scholar
  122. 122.
    Fong JA, Ruebner BH (1974) Primary leiomyosarcoma of the liver. Hum Pathol 5:115–119PubMedGoogle Scholar
  123. 123.
    Bloustein PA (1978) Hepatic leiomyosarcoma: Ultrastructural study and review of the differential diagnosis. Hum pathol 9:713–716PubMedGoogle Scholar
  124. 124.
    Chen KTK (1983) Hepatic leiomyosarcoma. J Surg Oncol 24:325–328PubMedGoogle Scholar
  125. 125.
    Callego MM, Merlo RR, Pascual BG (1984) Leiomyosarcoma hepatico primario. Gastroenterol Hepatol 7:77–81Google Scholar
  126. 126.
    O’Leary MR, Hill RB, Levine RA (1982) Peritonescopic diagnosis of primary leiomyosarcoma of liver. Hum Pathol 13:76–78PubMedGoogle Scholar
  127. 127.
    Hara T, Nakata H, Tsujimoto M, Nakatani T, Nishioka S, Yataka I, Tobuse K, Shoji S, Katsumi M, Gen E (1983) Primary leiomyosarcoma of the liver. Acta Hepatol Jpn 24:1040–1046Google Scholar
  128. 128.
    Tomaszewski M-M, Kuenster T, Hartman K (1986) Leiomyosarcoma of ligamentum teres of liver: Case report. Ped Pathol 5:147–156Google Scholar
  129. 129.
    Koberle F, Pfleger R (1940) Lebervenenges chevulst mit dem Symptomenbild einer Endophlebitis obliterans hepatica. Wien Arch Intern Med 34: 73–85Google Scholar
  130. 130.
    MacMahon HE, Ball HG (1971) Leiomyosarcoma of hepatic vein and the Budd-Chiari syndrome. Gastroenterology 61:239–243PubMedGoogle Scholar
  131. 131.
    Alberti-Flor JJ, O’Hara MF, Weaver F, Evans J, McClure R, Dunn GD (1985) Malignant fibrous histiocytoma of the liver. Gastroenterology 89: 890–893PubMedGoogle Scholar
  132. 132.
    Conran RM, Stocker JT (1985) Malignant fibrous histiocytoma of the liver—A case report. Amer J Gastroenterol 80:813–815Google Scholar
  133. 133.
    Basset F, Nezelof C, Ferrans VJ (1983) The histiocytoses. In: Sommers SL, Rosen PR (eds) Pathology annual, part 2, vol 18. Appleton-Century-Crofts, Norwalk, pp 27–28Google Scholar
  134. 134.
    Broadbent V, Pritchard J (1985) Histiocytosis X—Current controversies. Arch Dis Child 60:605–607PubMedGoogle Scholar
  135. 135.
    Favara BE, McCarthy RC, Mierau GW (1986) Histiocytosis X. In: Finegold M (ed) Pathology of neoplasia in children and adolescents. Saunders, Philadelphia, pp 126–144Google Scholar
  136. 136.
    Grosfeld JL, Fitzgerald JG, Wagner VM, Newton WA, Brehner RL (1976) Portal hypertension in infants and children with histiocytosis X. Am J Surg 131:108–113PubMedGoogle Scholar
  137. 137.
    Favara BE, McCarthy RC, Mierau GW (1983) Histiocytosis X. Hum Pathol 14:663–676PubMedGoogle Scholar
  138. 138.
    Thompson HH, Pitt HA, Lewin KG, Longmire WP (1984) Sclerosing cholangitis and histiocytosis X. Gut 25: 526–530PubMedGoogle Scholar
  139. 139.
    Harrist TH, Bhan AK, Murphy GF, Soto S, Berman RS, Gellis SE, Freedman S, Mihin MC (1983) Histiocytosis X: In situ characterization of cutaneous infiltrates with monoclonal antibodies. Am J Clin Pathol 79:294–300PubMedGoogle Scholar
  140. 140.
    Beckstead, JH, Wood GS, Turner RR (1984) Histiocytosis X cells and Langerhans cells: Enzyme histochemical and immunologic similarities. Hum Pathol 15:826–833PubMedGoogle Scholar
  141. 141.
    Wieczorek R, Greco MA, McCarthy K, Bonetti F, Knowles DM (1986) Familial erythrophagocytic, lymphohistiocytosis: Immunophenotypic, immunohistochemical and ultrastructural demonstration of the relation to sinus histiocytes. Hum Pathol 17: 55–63PubMedGoogle Scholar
  142. 142.
    Gupta SM, Kranioinkel RN, Herrera NE (1980) Pathogenesis of jaundice in histiocytic medullary reticulosis: A correlative scintigraphic, histologic and biochemical study. Am J Gastroenterol 73: 500–502PubMedGoogle Scholar
  143. 143.
    Jurco S, Starling K, Hawkins EP (1983) Malignant histiocytosis in childhood: Morphologic considerations. Hum Pathol 14:1059–1065PubMedGoogle Scholar
  144. 144.
    Ducatman BS, Wick MR, Morgan TW, Banks PM, Pierre RV (1984) Malignant histiocytosis: A clinical, histologic and immunohistochemical study of 20 cases. Hum Pathol 15: 368–377PubMedGoogle Scholar
  145. 145.
    Van der Volk P, Meijer CJLM (1985) Histiocytic sarcoma: Clinical picture, morphology, markers, differential diagnosis. In: Sommers SC, Rosen PP, Fechner RE (eds): Pathology annual, part 2, vol 20. Appleton-Century-Crofts, Norwalk, pp 1–28Google Scholar
  146. 146.
    Colby TV, LaBreque DR (1982) Lymphoreticular malignancy presenting as fulminant hepatic disease. Gastroenterology 82:339–345PubMedGoogle Scholar
  147. 147.
    Osborne BN, Butler JJ, Guarda LA (1985) Primary lymphoma of the liver: Ten cases and a review of the literature. Cancer 56:2902–2910PubMedGoogle Scholar
  148. 148.
    Caccamo D, Pervez NK, Marchevsky A (1986) Primary lymphoma of the liver. Arch Pathol Lab Med 110:553–555PubMedGoogle Scholar

Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Kamal G. Ishak
    • 1
  1. 1.Department of Hepatic PathologyArmed Forces Institute of PathologyUSA

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