Clinical Classification and Incidence of Malignant Hyperthermia in Japan

  • Osafumi Yuge
  • Michio Morio
  • Hirosato Kikuchi
  • Keiko Mukaida
  • Yasuhiro Maehara
  • Masakazu Nakao
  • Masashi Kawamoto
Conference paper


Denborough and Lovell [1] first described malignant hyperthermia (MH) as an inherited syndrome in 1960. At present, it is generally accepted that MH is triggered by many anesthetics. Succinylcholine chloride (SCC) and volatile anesthetics have been especially implicated as important triggering drugs [2,3]. With these triggering drugs, induced hypermetabolism produces tachycardia, increased O2 consumption and CO2 production, premature ventricular contraction, hypotension and hypertension, cyanosis, tachypnea, muscle rigidity, and hyperthermia as the signs of MH. Also seen as complications of MH are electrolyte imbalances, myoglobinuria, hyperkalemia, creatine phosphokinase (CPK) elevation, impaired coagulation, renal failure, and severe metabolic and respiratory acidosis.


Volatile Anesthetic Malignant Hyperthermia Malignant Hyperthermia Muscle Rigidity Malignant Hyperthermia Susceptibility 
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Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Osafumi Yuge
    • 1
  • Michio Morio
    • 2
  • Hirosato Kikuchi
    • 3
  • Keiko Mukaida
    • 1
  • Yasuhiro Maehara
    • 1
  • Masakazu Nakao
    • 1
  • Masashi Kawamoto
    • 1
  1. 1.Department of Anesthesiology and Critical Care MedicineHiroshima University School of MedicineHiroshima, 734Japan
  2. 2.Chugoku Rosai General HospitalKure, HiroshimaJapan
  3. 3.First Department of AnesthesiologyToho University School of MedicineTokyo, 143Japan

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