Our knowledge and understanding of the pharmacogenetic disease malignant hyperthermia (MH) has been significantly advanced through investigations of the porcine animal model. The distinction between “trigger” and “safe” anesthetics for MH-susceptible (MHS) human patients was originally based on the results of testing these drugs in the MHS pig [1,2]. The efficacy of dantrolene sodium for treating and preventing MH was discovered by Harrison  via experiments with MH pigs. Subsequent to its discovery in pigs, MHS was reported to occur in other species including the dog , cat , and horse . Because MH in man represents a spectrum of susceptibility  and is genetically heterogenous , thorough investigations of MH among different animal species may provide important genetic and epigenetic information that will further advance our understanding of MH in man. In this chapter, I attempt to document the current state of knowledge regarding MH in dogs, focusing on the interesting genetic and phenotypic differences between MH in dogs and in pigs and how understanding the basis for these differences may have an impact on our understanding of MH in man.
KeywordsMalignant Hyperthermia Malignant Hyperthermia Malignant Hyperthermia Susceptibility Dantrolene Sodium Skeletal Muscle Sarcoplasmic Reticulum
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