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Malignant Hyperthermia pp 119–128Cite as

Fatty Acids: Potentially Crucial Modulators of the Malignant Hyperthermia Syndrome

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Abstract

While defects in the ryanodine receptor may in some cases be necessary to impart the potential for malignant hyperthermia (MH) susceptibility, these defects are not sufficient to account for the MH syndrome. Obvious examples include swine homozygous for the proposed ryanodine receptor arginine to cysteine #615 MH mutation that do not exhibit an MH reaction at a young age [1] and those that do not consistently exhibit a reaction even as an adult, despite the administration of more than adequate amounts of triggering agents [2].

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, Hahnemann University, Philadelphia, PA, 19102, USA

    Jeffrey E. Fletcher

  2. Department of Anatomy, Hahnemann University, Philadelphia, PA, 19102, USA

    Steven J. Wieland

Authors
  1. Jeffrey E. Fletcher
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  2. Steven J. Wieland
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Editor information

Editors and Affiliations

  1. Chugoku Rosai General Hospital, Hiroshima University, 737-01, Kure, Hiroshima, Japan

    Michio Morio M.D., Ph.D. (Professor Emeritus, Director General) (Professor Emeritus, Director General)

  2. The First Department of Anesthesiology, Toho University School of Medicine, Ohta-ku, Tokyo, 143, Japan

    Hirosato Kikuchi M.D., Ph.D. (Chairman and Professor) (Chairman and Professor)

  3. Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, 734, Japan

    Osafumi Yuge M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

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© 1996 Springer-Verlag Tokyo

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Fletcher, J.E., Wieland, S.J. (1996). Fatty Acids: Potentially Crucial Modulators of the Malignant Hyperthermia Syndrome. In: Morio, M., Kikuchi, H., Yuge, O. (eds) Malignant Hyperthermia. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68346-9_17

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  • DOI: https://doi.org/10.1007/978-4-431-68346-9_17

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68348-3

  • Online ISBN: 978-4-431-68346-9

  • eBook Packages: Springer Book Archive

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