Summary
Sixty patients with sustained essential systolo-diastolic hypertension were submitted to a stepped-care approach in order to obtain an adequate control of blood pressure with antihypertensive drugs. After a 24-month follow-up survey, 30 patients (group I) had adequate control of both systolic and diastolic pressures; while, in another 30 patients (group II), diastolic pressure was controlled and systolic pressure remained elevated. Compared to patients in group I with the same age and mean arterial pressure, patients in group II exhibited higher values in carotido-femoral pulse wave velocity (P< 0.001). The higher values of pulse wave velocity could not be explained on the basis of differences in therapeutic regimen or associated clinical atherosclerotic diseases. The Sokolow Lyon index was significantly higher in group II than in group I. The study provided evidence that, in patients treated for systolodiastolic hypertension: (1) an adequate control of diastolic pressure may be obtained while systolic pressure remains elevated; and (2) the increased systolic pressure indicates an enhanced rigidity of the arterial wall with possible consequence to cardiac structure and function.
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© 1989 Springer Japan
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Safar, M.E., Soubies, P.L., Safavian, A.M., Asmar, R.G., Laurent, S. (1989). Antihypertensive Therapy with Uncontrolled Systolic Pressure and Increased Aortic Rigidity. In: Omae, T., Zanchetti, A. (eds) How Should Elderly Hypertensive Patients Be Treated?. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68340-7_12
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DOI: https://doi.org/10.1007/978-4-431-68340-7_12
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68342-1
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