Summary of Chapter 6: Cytomolecular Aspects of Polyposis
The well known adenoma-carcinoma sequence hypothesis implies that adenoma is a precursor to adenocarcinoma. The development of hundreds of adenomatous polyps in the colorectal epithelium is a cardinal feature of the dominantly inherited familial adenomatous polyposis (FAP) due to lesions in a putative gene designated as adenomatous polyposis coli (APC) in the chromosome 5q15-q22 region. Herrera’s report on a deletion in 5q in a FAP patient with multiple congenital malformations gave the first clue on the chromosomal localization of APC.
KeywordsFamilial Adenomatoua Polypoaia Adenomatous Polyposis Coli Radiation Hybrid Familial Adenomatoua Polypoaia Patient Adenomatous Polyposis Coli Gene
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