Abstract
Increased polyamine biosynthetic activity and raised levels of intracellular polyamines are commonly associated with abnormal and induced proliferative states. Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase are the known rate-limiting enzymes in polyamine biosynthesis. Herein, we report results from our group in relation to the activity of these enzymes in “normal looking” mucosa and neoplasias of the colon. Both enzymes tend to reflect neoplastic progression (mucosa<polyp < carcinoma). During these studies, we observed low levels of activity in the “normal looking” mucosa of colons containing a neoplasia, but high levels of ODC in “normal looking” mucosa of the same colons after the removal of their neoplasias. These observations suggest a role of ODC as a possible biochemical marker of a colon harboring a neoplasia.
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References
Berger FG, Szymanski P, Read E, Watson G (1984) Androgen-regulated Ornithine Decarboxylase in RNA of mouse kidney. J Biol Chem 259:7941–7946
Herrera L, Petrelli N (1988) Ornithine Decarboxylase activity in hepatic and extra-hepatic metastases from colorectal cancer. Dis Col Rectum 31:352–354
Herrera OL, Justiniano J, Castillo N, Petrelli N, Stulc J, Mittelman A (1987) Metastases in small lymph nodes from colon cancer. Arch Surg 122:1253–1256
Herrera-Ornelas L, Porter C, Pera P, Greco W, Petrelli N, Mittelman A (1987) A comparison of Ornithine Decarboxylase activity in human large bowel mucosa, polyps and colorectal adenocarcinoma. J Surg Res 42:56–60
Lawson M, White L, Coyle P, Butler R, Roberts-Thomson I, Comyers R (1989) An assessment of proliferative and enzyme activity in transitional mucosa adjacent to colonic cancer. Cancer 64:1061–1066
Luk GD, Baylin SB (1984) Ornithine Decarboxylase as a biologic marker in familial colonic polyposis. New Engl J Med 311:80–83
Moorehead RJ, Hoper M, McKelvey STD (1987) Ornithine Decarboxylase activity in rectal mucosa as marker for colorectal adenomas and carcinomas. Br J Surg 87:364–365
Nichioka K, Romsdahl MN, McMurtrey MJ (1977) Serum polyamine alterations in surgical patients with colorectal carcinomas. J Surg Oncol 9:555–562
Pegg AE, McCann PP (1982) Polyamine metabolism and function. Am J Physiol 243:C212–221
Porter CW, Herrera-Ornelas L, Clark J (1986) Polyamine biosynthetic enzyme activities correlated with neoplastic progression in human colorectal tissue. Proc Amer Assn Cancer Res (abstract); Vol. 27, pp 159
Porter C, Herrera-Ornelas L, Pera P, Petrelli N, Mittelman A (1987) Polyamine biosynthetic activity in normal and neoplastic human colorectal tissues. Cancer 60: 1275–1281
Radford DM, Eddy R, Haley L, Henry W, Pegg AE, Pajuney A, Shows TB (1988) Gene sequences coding for S-Adenosylmethionine Decarboxylase are present on chromosome 6 and the X and are not amplified in colon neoplasia. Cytogen & Cell Genetics 49: 285–288
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© 1990 Springer Japan
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Herrera, L., Petrelli, N.J., Vial, G. (1990). Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers in Human Colonic Neoplasia. In: Utsunomiya, J., Lynch, H.T. (eds) Hereditary Colorectal Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68337-7_44
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DOI: https://doi.org/10.1007/978-4-431-68337-7_44
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68339-1
Online ISBN: 978-4-431-68337-7
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