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Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers in Human Colonic Neoplasia

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Abstract

Increased polyamine biosynthetic activity and raised levels of intracellular polyamines are commonly associated with abnormal and induced proliferative states. Ornithine Decarboxylase and S-Adenosylmethionine Decarboxylase are the known rate-limiting enzymes in polyamine biosynthesis. Herein, we report results from our group in relation to the activity of these enzymes in “normal looking” mucosa and neoplasias of the colon. Both enzymes tend to reflect neoplastic progression (mucosa<polyp < carcinoma). During these studies, we observed low levels of activity in the “normal looking” mucosa of colons containing a neoplasia, but high levels of ODC in “normal looking” mucosa of the same colons after the removal of their neoplasias. These observations suggest a role of ODC as a possible biochemical marker of a colon harboring a neoplasia.

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© 1990 Springer Japan

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Herrera, L., Petrelli, N.J., Vial, G. (1990). Ornithine Decarboxylase (ODC) and S-Adenosylmethionine Decarboxylase (AdoMetDC) as Markers in Human Colonic Neoplasia. In: Utsunomiya, J., Lynch, H.T. (eds) Hereditary Colorectal Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68337-7_44

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  • DOI: https://doi.org/10.1007/978-4-431-68337-7_44

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68339-1

  • Online ISBN: 978-4-431-68337-7

  • eBook Packages: Springer Book Archive

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