Summary of Chapter 4: Chemoprevention of Colorectal Cancer

  • Martin Lipkin
  • Paul Rozen
Conference paper


In recent years increasing interest has developed in human studies in the field of chemoprevention. Several factors have contributed to this interest. They include preclinical studies showing tumor-inhibitory activity in many classes of naturally occurring nutrients; and studies demonstrating that biochemical changes within cells (intermediate biomarkers) might identify tumor inhibition in humans at an early stage. Recent reviews of this topic include Wattenberg (1985), Bertram (1987), Lipkin (1988).


Proliferate Cell Nuclear Antigen Beta Carotene Ornithine Decarboxylase Chemopreventive Agent Tritiated Thymidine 
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  1. Wattenberg LW. (1985) Chemoprevention of cancer. Cancer Res 45: 1–8.PubMedCrossRefGoogle Scholar
  2. Bertram JS, Kolonel LN. and Meyskens FL, Jr. (1987) Rationale and strategies for chemoprevention of cancer in humans. Cancer Res. 47: 3012–3031.PubMedGoogle Scholar
  3. Lipkin M. (1988) Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Perspectives in cancer research, Cancer Research, 48: 235–245.Google Scholar

Copyright information

© Springer Japan 1990

Authors and Affiliations

  • Martin Lipkin
  • Paul Rozen

There are no affiliations available

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