Summary of Chapter 4: Chemoprevention of Colorectal Cancer
In recent years increasing interest has developed in human studies in the field of chemoprevention. Several factors have contributed to this interest. They include preclinical studies showing tumor-inhibitory activity in many classes of naturally occurring nutrients; and studies demonstrating that biochemical changes within cells (intermediate biomarkers) might identify tumor inhibition in humans at an early stage. Recent reviews of this topic include Wattenberg (1985), Bertram (1987), Lipkin (1988).
KeywordsProliferate Cell Nuclear Antigen Beta Carotene Ornithine Decarboxylase Chemopreventive Agent Tritiated Thymidine
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- Lipkin M. (1988) Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects. Perspectives in cancer research, Cancer Research, 48: 235–245.Google Scholar