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Medical/Legal Concerns in the Management of Patients from Lynch Syndromes Kindreds

  • G. Cristofaro
  • E. di Giulio
  • P. L. Mingazzini
  • P. Bufo
  • S. Senatore
  • P. M. Lynch
  • P. Watson
  • J. F. Lynch
  • H. T. Lynch
Conference paper

Abstract

The management of patients affected or at risk for the Lynch Syndromes must focus upon its natural history, early age of onset, predilection for the proximal Colon, excess of synchronous and metachronous Colon cancer, and autosomal dominant mode of inheritance (Lynch Syndrome I). In addition, predisposition to carcinoma of the endometrium, ovary, stomach, pancreas, and other anatomic sites are integral features of the Lynch Syndrome II counterpart [Lynch H.T., 1985, 1988, 1988a]. The absence of biomarkers for the genotype and/ or premonitory signs, such as multiple colonic adenomatous polyps, as occurs in the familial adenomatous polyposis (FAP) syndrome, makes the job of the diagnostician a vexing one [Cristofaro G., 1988, 1989].

Keywords

Familial Adenomatous Polyposis Lynch Syndrome High Risk Subject Double Contrast Barium Enema Adenoma Carcinoma Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Japan 1990

Authors and Affiliations

  • G. Cristofaro
  • E. di Giulio
  • P. L. Mingazzini
  • P. Bufo
  • S. Senatore
  • P. M. Lynch
  • P. Watson
  • J. F. Lynch
  • H. T. Lynch

There are no affiliations available

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