Hereditary Nonpolyposis Colorectal Cancer and Tumorigenesis in the Human Body
At the National Cancer Center Hospital in Tokyo, a review has been made of 1,898 case histories, from 1962 through 1986, of colorectal cancer patients who did not exhibit the polyposis syndrome, with particular emphasis placed on identifying cases of familial aggregation and cases involving multiple cancers in the large intestine and/or other organs.
From this total number, found were 141 cases of multiple colorectal cancer (7.4%) and 179 cases of a colorectal cancer associated with an extracolonic cancer (9.4%). Also found were 100 cases (5.3%) of hereditary nonpolyposis colorectal cancer (HNPCC). In the HNPCC cases, several characteristics were found common: an early onset of the cancer (mean: 53.2 years), proximally-sited colonic tumors (38.0% in the right colon), and a high frequency of multiple cancers (31.0%). Among theses HNPCC patients, 7 cases of an associated adenocarcinoma of the uterine body and/or ovaries were identified.
These findings are discussed, along with an overall view of HNPCC clinico-genetic characteristics. [ Key words: cancer family syndrome; colon cancer; hereditary nonpolyposis colorectal cancer; endometrial cancer; hereditary tumor]
KeywordsColorectal Cancer Endometrial Cancer Lynch Syndrome Hereditary Nonpolyposis Colorectal Cancer Polyposis Syndrome
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