Follow-up Study of Associated Tumors in Cases of Familial Adenomatous Polyposis
Between 1962 and 1988 we have experienced at the National Cancer Center Hospital 55 cases of familial adenomatous polyposis(FAP) of the colon involving 29 families (43 males, 12 females). The prognosis of the various accompanying FAP tumors were as follows: 1) Benign tumors originated from ectodermal, mesodermal and endodermal tissue had already developed during early childhood and had increased in size and number by puberty, though it was suspected that the tumor growth had generally stopped from that time onwards; 2) Mandibular osteomas developed near the roots of the permanent teeth after the eruption and loss of the deciduous teeth, suggesting that the abnormal repair of the osseous damage plays a great role in mandibular tumorigenesis. 3) Malignant tumors were seen to develop in the glandular epithelium that originated from the endodermal tissue, such as the colon, the small intestine, the stomach, and the thyroid. C Key words: Familial adenomatous polyposis; Associated lesion; Natural history; Mandibular osteoma]
KeywordsFamilial Adenomatous Polyposis Deciduous Tooth Desmoid Tumor Permanent Tooth Glandular Epithelium
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