Histological Growth Patterns of Hepatocellular Carcinoma
Macroscopically, HCC grows in either an infiltrative or an expansive pattern. The growth patterns at the tumor-nontumor boundary, however, can be histologically divided into two basic categories, sinusoidal and replacing. Occasionally, a lesion is encountered that pushes normal hepatic cells ahead of it as it grows—although it is primarily of the replacing type—because of the predominance of expansive growth. In such lesions, a pseudocapsule of reticulin fibers is formed, concentrated along the boundary (pseudocapsular growth). These lesions are classified separately and designated pseudocapsular.
KeywordsHepatocellular Carcinoma Hepatic Cell Extrahepatic Metastasis Sinusoidal Endothelial Cell Expansive Pattern
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