Histological Growth Patterns of Hepatocellular Carcinoma

  • Toshiro Nakashima
  • Masamichi Kojiro


Macroscopically, HCC grows in either an infiltrative or an expansive pattern. The growth patterns at the tumor-nontumor boundary, however, can be histologically divided into two basic categories, sinusoidal and replacing. Occasionally, a lesion is encountered that pushes normal hepatic cells ahead of it as it grows—although it is primarily of the replacing type—because of the predominance of expansive growth. In such lesions, a pseudocapsule of reticulin fibers is formed, concentrated along the boundary (pseudocapsular growth). These lesions are classified separately and designated pseudocapsular.


Hepatocellular Carcinoma Hepatic Cell Extrahepatic Metastasis Sinusoidal Endothelial Cell Expansive Pattern 


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Copyright information

© Springer Japan 1987

Authors and Affiliations

  • Toshiro Nakashima
    • 1
    • 2
  • Masamichi Kojiro
    • 3
  1. 1.School of MedicineKurume UniversityJapan
  2. 2.Research InstituteKurume Koga HospitalKurume, 830Japan
  3. 3.The First Department of PathologyKurume University School of MedicineKurume, 830Japan

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