Advertisement

Heart Failure pp 161-174 | Cite as

Endothelin Antagonism in the Treatment of Heart Failure

  • Takashi Miyauchi
  • Yasuro Sugishita
Conference paper

Abstract

Cardiac myocytes and vascular endothelial cells produce endothelin-1, which increases the contractility of cardiac muscle and of vascular smooth muscle. Endothelin-1 also has long-term effects, such as myocardial hypertrophy, and causes cellular injury in cardiac myocytes. The production of endothelin-1 is markedly increased in the failing heart. We discuss evidence favoring the use of an endothelin receptor antagonist as a new drug for heart failure. Long-term treatment with an endothelin receptor antagonist greatly improves the survival rate of animals (rats, hamsters, etc.) with chronic heart failure. This beneficial effect is accompanied by amelioration of left ventricular dysfunction. The myocardial endothelin system appears to be a novel and important target for therapeutic intervention in heart failure.

Keywords

Chronic Heart Failure Cardiac Myocytes Dual Antagonist Permanent Coronary Artery Ligation Shear Stress Responsive Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Smith TW, Braunwald E, Kelly RA (1992) In: Braunwald E (ed) Heart disease. W.B. Saunders, pp 464–519Google Scholar
  2. 2.
    Ho KK, Pinsky JL, Kannel WB, Levy D (1993) J Am Coll Cardiol 22: 6A - 13APubMedCrossRefGoogle Scholar
  3. 3.
    Ho KK, et al. (1993) Circulation 88: 107–115PubMedGoogle Scholar
  4. 4.
    Pfeffer MA (1995) Annu Rev Med 46: 455–466PubMedCrossRefGoogle Scholar
  5. 5.
    Kannel WB, et al. (1979) Am J Cardiol 44: 53–59PubMedCrossRefGoogle Scholar
  6. 6.
    Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y (1996) Nature 384: 353–355PubMedCrossRefGoogle Scholar
  7. 7.
    Inoue A, et al. (1989) Proc Natl Acad Sci USA 86: 2863–2867PubMedCrossRefGoogle Scholar
  8. 8.
    Inoue A, et al. (1989) J Biol Chem 264: 14954–14959PubMedGoogle Scholar
  9. 9.
    Errori T, et al. (1992) Biochem Pharmacol 44: 2409–2411CrossRefGoogle Scholar
  10. 10.
    Kurihara H, et al. (1989) Biochem Biophys Res Commun 159: 1435–1440PubMedCrossRefGoogle Scholar
  11. 11.
    Maki S, Miyauchi T, et al. (1998) J Cardiovasc Pharmacol 31: S412 - S416PubMedCrossRefGoogle Scholar
  12. 12.
    Malek A, Izumo S (1992) Am J Physiol 263: C389 - C396PubMedGoogle Scholar
  13. 13.
    Yoshizumi M, et al. (1989) Biochem Biophys Res Commun 161: 859–864PubMedCrossRefGoogle Scholar
  14. 14.
    Malek AM, Greene AL, Izumo S (1993) Proc Nati Acad Sci USA 90: 5999–6003CrossRefGoogle Scholar
  15. 15.
    Inoue A, Yanagisawa M, Kimura S. Kasuya Y, Miyauchi T, Goto K, Masaki T (1989) Proc Nati Acad Sci USA 86: 2863–2867CrossRefGoogle Scholar
  16. 16.
    Masaki T, Kimura S. Yanagisawa M, Goto K (1991) Circulation 84: 1457–1468PubMedGoogle Scholar
  17. 17.
    Arai H, et al. (1990) Nature 348: 730–732PubMedCrossRefGoogle Scholar
  18. 18.
    Sakurai T, Yanagisawa M, Takuwa Y, Miyazaki H, Kimura S, Goto K, Masaki T (1990) Nature 348: 732–735PubMedCrossRefGoogle Scholar
  19. 19.
    Rubanyi GM, Polokoff MA (1994) Pharmacol Rev 45: 325–415Google Scholar
  20. 20.
    Sakurai T, Yanagisawa M, Masaki T (1992) Trends Pharmacol Sci 13: 103–108PubMedCrossRefGoogle Scholar
  21. 21.
    Badr KF, et al. (1989) J Clin Invest 83: 336–342PubMedCrossRefGoogle Scholar
  22. 22.
    Takuwa Y, et al. (1990) J Clin Invest 85: 653–658PubMedCrossRefGoogle Scholar
  23. 23.
    Simonson MS, Dunn MJ (1990) FASEB J 4: 2989–3000PubMedGoogle Scholar
  24. 24.
    Goto K, et al. (1989) Proc Natl Acad Sci USA 86: 3915–3918PubMedCrossRefGoogle Scholar
  25. 25.
    Chua BH, et al. (1992) Am J Physiol 262: E412 - E416PubMedGoogle Scholar
  26. 26.
    Bogoyevitch MA, et al. (1992) FEBS Lett 317: 271–275CrossRefGoogle Scholar
  27. 27.
    Simonson MS (1993) Physiol Rev 73: 375–411PubMedGoogle Scholar
  28. 28.
    Okazawa M, Shiraki T, Ninomiya H, Kobayashi S, Masaki T (1998) J Biol Chem 273: 12584–12592PubMedCrossRefGoogle Scholar
  29. 29.
    Wang Y, et al. (1994) Am J Physiol 267: C1130–1135PubMedGoogle Scholar
  30. 30.
    Sugawara F, Ninomiya H, Okamoto Y, Miwa S, Mazda O, Katsura Y, Masaki T (1996) Mol Pharmacol 49: 447–457PubMedGoogle Scholar
  31. 31.
    Cazaubon S, et al. (1994) Biochem J 293: 381–386Google Scholar
  32. 32.
    Cazaubon S, et al. (1994) J Biol Chem 269: 24805–24809PubMedGoogle Scholar
  33. 33.
    Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T Nature 332: 411–415Google Scholar
  34. 34.
    Ishikawa T, et al. (1988) Am J Physiol 255 (Heart Circ Physiol 24): H970 - H973PubMedGoogle Scholar
  35. 35.
    Suzuki T, Kumazaki T, Mitsui Y (1993) Biochem Biophys Res Commun 193: 823–830CrossRefGoogle Scholar
  36. 36.
    Wei CM, et al. (1994) Circulation 89: 1580–1586PubMedGoogle Scholar
  37. 37.
    Goto K, Warner TD (1995) Nature 375: 539–540PubMedCrossRefGoogle Scholar
  38. 38.
    Miyauchi T, et al. (1993) Circ Res 73: 887–897PubMedGoogle Scholar
  39. 39.
    Ito H, et al. (1994) Circulation 89: 2198–2203PubMedGoogle Scholar
  40. 40.
    Shubeita HE, et al. (1990) J Biol Chem 265: 20555–20562PubMedGoogle Scholar
  41. 41.
    Stawski G, Olsen UB, Grande P (1991) Eur J Pharmacol 201: 123–124PubMedCrossRefGoogle Scholar
  42. 42.
    Prasad MR (1991) Biochem Biophys Res Commun 174: 952–957PubMedCrossRefGoogle Scholar
  43. 43.
    McMurray JJ, et al. (1992) Circulation 85: 1374–1379PubMedGoogle Scholar
  44. 44.
    Stewart DJ, Cernacek, Costello KB, Rouleau JL (1992) Circulation 85: 510–517PubMedGoogle Scholar
  45. 45.
    Underwood RD, et al. (1992) Am J Physiol 263 (Heart Circ Physiol 32): H951 - H955PubMedGoogle Scholar
  46. 46.
    Margulies KB, et al. (1990) Circulation 82: 2226–2230PubMedCrossRefGoogle Scholar
  47. 47.
    Miyauchi T, et al. (1989) Lancet ii (8653):53–54Google Scholar
  48. 48.
    Sakai S, Miyauchi T, Sakurai T, Kasuya Y, Ihara M, Yamaguchi I, Goto K, Sugishita Y (1996) Circulation 93: 1214–1222PubMedGoogle Scholar
  49. 49.
    Miyauchi T, et al. (1998) J Cardiovasc Pharmacol 31: S298 - S301PubMedCrossRefGoogle Scholar
  50. 50.
    Miyauchi T, et al. (1998) Jpn Circ J 62 (Suppl I): 44 (abstract)Google Scholar
  51. 51.
    Packer M, et al. (1991) N Engl J Med 325: 1468–1475PubMedCrossRefGoogle Scholar
  52. 52.
    Katz AM (1986) Circulation 73:1I1–184-III-188Google Scholar
  53. 53.
    Yorikane R, Koike H (1990) Jpn J Pharmacol 53: 259–263PubMedCrossRefGoogle Scholar
  54. 54.
    Sakai S, Miyauchi T, et al. (1996) J Am Coll Cardiol 28: 1580–1588PubMedCrossRefGoogle Scholar
  55. 55.
    Sakai S, Miyauchi T, et al. (1998) Int J Angiol 7: 160–164CrossRefGoogle Scholar
  56. 56.
    Sakai S, Miyauchi T, et al. (1997) Circulation 96: I - 628 (abstract)Google Scholar
  57. 57.
    Sakai S, Miyauchi T, et al. (1998) J Cardiovasc Pharmacol 31: 5302 - S305CrossRefGoogle Scholar
  58. 58.
    Miyauchi T, et al. (1998) Jpn J Pharmacol 76 (Suppl I): 6P (abstract)Google Scholar
  59. 59.
    Emori T, et al. (1989) Biochem Biophys Res Commun 160: 93–100PubMedCrossRefGoogle Scholar
  60. 60.
    Yoshizumi M, et al. (1989) Biochem Biophys Res Commun 161: 859–864PubMedCrossRefGoogle Scholar
  61. 61.
    Sumpio BE, Widmann MD (1990) Surgery 108: 277–281PubMedGoogle Scholar
  62. 62.
    Ito H, et al. (1993) J Clin Invest 92: 398–403PubMedCrossRefGoogle Scholar
  63. 63.
    Yorikane R, Sakai S, Miyauchi T, Sakurai T, Sugishita Y, Goto K (1993) FEBS Lett 332: 31–34PubMedCrossRefGoogle Scholar
  64. 64.
    Reiss K, et al. (1993) Am J Physiol 264 (Heart Circ Physiol 33): H760 - H769PubMedGoogle Scholar
  65. 65.
    Inoue A, et al. (1989) J Biol Chem 264: 14954–14959PubMedGoogle Scholar
  66. 66.
    Yanagisawa M, et al. (1989) J Cardiovasc Pharmacol 13 (Suppl 5): S13 - S17PubMedCrossRefGoogle Scholar
  67. 67.
    Hirata Y, et al. (1989) Biochem Biophys Res Commun 160: 1438–1444PubMedCrossRefGoogle Scholar
  68. 68.
    Sakurai T, Morimoto H, Kasuya Y, Takuwa Y, Nakauchi H. Masaki T, Goto K (1992) Biochem Biophys Res Commun 186: 342–347PubMedCrossRefGoogle Scholar
  69. 69.
    Molenaar P, et al. (1993) Circ Res 72: 526–538PubMedGoogle Scholar
  70. 70.
    Omland T, et al. (1994) Circulation 89: 1573–1579PubMedGoogle Scholar
  71. 71.
    Pacher R, et al. (1996) J Am Coll Cardiol 27: 633–641PubMedCrossRefGoogle Scholar
  72. 72.
    Krum H, et al. (1996) Am Heart J 131: 337–341PubMedCrossRefGoogle Scholar
  73. 73.
    Kiowski W, et al. (1995) Lancet 346: 732–736PubMedCrossRefGoogle Scholar
  74. 74.
    Cody RJ, et al. (1992) Circulation 85: 504–509PubMedGoogle Scholar
  75. 75.
    Spinale FG, et al. (1997) Circulation 95: 1918–1929PubMedGoogle Scholar
  76. 76.
    Douglas SA (1997) Trends Pharmacol Sci 18: 408–412PubMedGoogle Scholar
  77. 77.
    Clozel M, et al. (1993) Nature 365: 759–761PubMedCrossRefGoogle Scholar
  78. 78.
    Clozel M, et al. (1994) J Pharmacol Exp Ther 270: 228–235PubMedGoogle Scholar
  79. 79.
    Elliott JD, et al. (1994) J Med Chem 37: 1553–1557PubMedCrossRefGoogle Scholar
  80. 80.
    Ohlstein EH, et al. (1994) Proc Natl Acad Sci USA 91: 8052–8056PubMedCrossRefGoogle Scholar
  81. 81.
    Reynolds EE, et al. (1995) J Pharmacol Exp Ther 273: 1410–1417PubMedGoogle Scholar
  82. 82.
    Williams DL, et al. (1995) J Pharmacol Exp Ther 275: 1518–1526PubMedGoogle Scholar
  83. 83.
    Hoshino T, et al. (1996) Jpn J Pharmacol 70 (Suppl I): 237 (abstract)Google Scholar
  84. 84.
    Hoshino T, et al. (1998) J Pharmacol Exp Ther 286: 643–649PubMedGoogle Scholar
  85. 85.
    Nagase T, et al. (1995) AFMC Internati Med Chem Symp P5M133 (abstract)Google Scholar
  86. 86.
    Kobayashi T, Miyauchi T, et al. (1998) Jpn Circ J 62 (Suppl I): 37 (abstract)Google Scholar
  87. 87.
    Wada A, et al. (1997) J Am Coll Cardiol 30: 1385–1392PubMedCrossRefGoogle Scholar
  88. 88.
    Goto K, Hama H, Kasuya Y (1996) Jap J Pharmacol 72: 261–290PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 2000

Authors and Affiliations

  • Takashi Miyauchi
    • 1
  • Yasuro Sugishita
    • 1
  1. 1.Cardiovascular Division, Department of Internal Medicine, Institute of Clinical MedicineUniversity of TsukubaTsukuba, IbarakiJapan

Personalised recommendations