Is Platelet Cytosolic Free Calcium and Serotonin Concentration and Blood Viscosity Different between Hypertensive and Normotensive Subjects?
The ability of cells in the vascular wall as well as platelets in calcium handling plays an important role in the pathogenesis of certain cardiovascular diseases and is found to be defective in hypertensive states. It is known that calcium plays a central role in the mediation of platelet function and maintenance 01 blood pressure. Serotonin (5-HT), a highly vasoactive amine, is another factor that has numerous vascular effects. Abnormalities of platelet 5-HT contents and kinetics may therefore affect vascular reactivity and platelet function as well. Since blood viscosity is a determinant of total peripheral resistance, which in turn is an important factor in the determination of arterial pressure, therefore changes in blood viscosity and other rheologic parameters are also seen in hypertensives or peripheral vascular diseases. In this study, we want to compare the difference in platelet intracellular calcium, serotonin concentration, and blood viscosity in normotensives and hypertensives.
KeywordsShear Rate Mean Arterial Pressure Blood Viscosity Total Peripheral Resistance Plasma Viscosity
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