Arachidonate 12-Lipoxygenase of Human Platelets
Thromboxane A2 is well known as a proaggregatory and vasoconstrictive compound . It is produced from arachidonic acid in platelets, and fatty acid cyclooxygenase responsible for the thromboxane synthesis is localized in the microsomal fraction of human platelets . There is another metabolic pathway of arachidonic acid in human platelets. The pathway is initiated by the reaction of arachidonate 12-lipoxygenase, which is localized predominantly in the cytosol of human platelets .
KeywordsArachidonic Acid Chronic Myeloid Leukemia Human Platelet Polycythemia Vera Essential Thrombocythemia
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