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Arachidonate 12-Lipoxygenase of Human Platelets

  • Shozo Yamamoto
  • Satoshi Matsuda
  • Jun Murakami
  • Yasuchika Yamamoto
  • Yumiko Konishi
  • Chieko Yokoyama
  • Toshiya Arakawa
  • Yoshitaka Takahashi
  • Tanihiro Yoshimoto
  • Yasuo Mimura
  • Minoru Okuma
Conference paper

Abstract

Thromboxane A2 is well known as a proaggregatory and vasoconstrictive compound [1]. It is produced from arachidonic acid in platelets, and fatty acid cyclooxygenase responsible for the thromboxane synthesis is localized in the microsomal fraction of human platelets [2]. There is another metabolic pathway of arachidonic acid in human platelets. The pathway is initiated by the reaction of arachidonate 12-lipoxygenase, which is localized predominantly in the cytosol of human platelets [3].

Keywords

Arachidonic Acid Chronic Myeloid Leukemia Human Platelet Polycythemia Vera Essential Thrombocythemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1993

Authors and Affiliations

  • Shozo Yamamoto
    • 1
  • Satoshi Matsuda
    • 2
  • Jun Murakami
    • 1
  • Yasuchika Yamamoto
    • 1
  • Yumiko Konishi
    • 2
  • Chieko Yokoyama
    • 1
  • Toshiya Arakawa
    • 1
  • Yoshitaka Takahashi
    • 1
  • Tanihiro Yoshimoto
    • 1
  • Yasuo Mimura
    • 2
  • Minoru Okuma
    • 3
  1. 1.Department of BiochemistryTokushima University, School of MedicineTokushima 770Japan
  2. 2.Department of OphthalmologyTokushima University, School of MedicineTokushima 770Japan
  3. 3.Department of Internal MedicineKyoto University, Faculty of MedicineKyoto 606Japan

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