Possible Involvement of Platelet Activating Factor (PAF) in Tissue Factor Generation and the Pathogenesis of Disseminated Intravascular Coagulation (DIC)

  • Z. Terashita
  • M. Kawamura
  • Y. Imura
  • K. Nishikawa
Conference paper


PAF is a highly potent lipid mediator with diverse biological actions such as activation of platelets and leukocytes, induction of hypotension and bronchoconstriction (1). In earlier papers, we reported that PAF may play important roles in the pathogenesis of anaphylactic shock in mice and endotoxin shock and DIC in rats using the first PAF antagonist, CV-3988 (2–5).


Tissue Factor Disseminate Intravascular Coagulation Disseminate Intravascular Coagulation Activate Partial Thromboplastin Time Diverse Biological Action 
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  1. 1.
    Braquet, P., Touqoui, L., Shen, T.Y. and Vargaftig, B.B. (1987) Pharmacol. Rev. 39: 97–145PubMedGoogle Scholar
  2. 2.
    Terashita, Z., Tsushima, S., Yoshioka, Y., Nomura, H., Inada. Y. and Nishikawa, K. (1983) Life Sci. 32: 1975–1982PubMedCrossRefGoogle Scholar
  3. 3.
    Terashita, Z., Imura, Y., Nishikawa, K. and Sumida, S. (1985) Eur. J. Pharmacol. 109: 257–261PubMedCrossRefGoogle Scholar
  4. 4.
    Terashita, Z., Imura, Y., Shino., A. and Nishikawa, K. (1987) J. Pharmacol. Exp. Ther. 243: 378–383PubMedGoogle Scholar
  5. 5.
    Imura, Y., Terashita, Z. and Nishikawa, K. (1986) Life Sci. 39: 111–117PubMedCrossRefGoogle Scholar
  6. 6.
    Mullar-Berghaus, G. (1989) Semin. Thromb. Haemost. 15: 58–86Google Scholar
  7. 7.
    Carson S.D. (1984) Prog. Clin. Pathol. 9: 1–14PubMedGoogle Scholar
  8. 8.
    Terashita, Z., Kawamura, M., Takatani, M., Tushima, S., Imura, Y. and Nishikawa, K. (1992) J. Pharmacol. Exp. Ther. 260: 748–755PubMedGoogle Scholar
  9. 9.
    Stockmans, E, Arnout, J., Depre, M., Schepper, ED., Angehrn, J.C. and Vermylen, J. (1991) Thromb. Haemost. 65: 1108 PGoogle Scholar
  10. 10.
    Kawamura, M., Terashita, Z., Imura, Y., Shino, A. and Nishikawa, K. (1992) Thromb. Res. in the press.Google Scholar
  11. 11.
    Fukuda, C, lijima, K and Nakamura K (1989) Clin. Chem. 35: 1897–1990PubMedGoogle Scholar
  12. 12.
    Terashita, Z., Imura, Y. and Nishikawa, K. (1990) In: Handley, D.A., Saunders, R.N., Houlihan, W.J. and Tomesch, J.C. (Eds.) Platelet-activating factor in endotoxin and immune diseases. Marcel Dekker,Inc.New York. NY. pp 547–575Google Scholar
  13. 13.
    Pleszczynski, M.R. (1990) J. Lipd. Med. 2: S77 - S82Google Scholar
  14. 14.
    Rabinovici, R., Esser, K.M., Lysko, P.G., Yue, T., Grisworld, D.E. Hillegass, L.M., Bugelski, P.J., Hallenbeck, J.M. and Feurstein,G(1991) Circ.Res. 69: 12–25Google Scholar
  15. 15.
    Gilmore, M.A., Proc. Natl. Acad. Sci. U.S.A. (1986) 83: 4533–4537CrossRefGoogle Scholar
  16. 16.
    Tanaka, M. (1989) Thromb. Res. 56: 201–211PubMedCrossRefGoogle Scholar
  17. 17.
    Hirata, M., Shimomura, Y. and Yoshida, M. (1991) Thromb. Haemost. 65: 1107 PGoogle Scholar
  18. 18.
    Leaver, H.A., Qu, J.M., Smith, G., Howie, A., Ross, W.B. and Tap, P.L. (1990) Immunopharmacol. 20: 105–113CrossRefGoogle Scholar
  19. 19.
    Barett, M.L., Lewis, G.P., Ward, S., Westwick, J. (1987) Br. J. Pharmacol 90: 113 PGoogle Scholar
  20. 20.
    Emeis, J.J. and Kluft, C. (1985) Blood 66: 86–91PubMedGoogle Scholar
  21. 21.
    Sakaguchi, K., Masugi, E, Chen, Y.H., Inoue, M., Ogihara, T. Yamada, K. and Yamastu, I. (1989) J. Lipid Med. 1: 171–173Google Scholar

Copyright information

© Springer Japan 1993

Authors and Affiliations

  • Z. Terashita
    • 1
  • M. Kawamura
    • 1
  • Y. Imura
    • 1
  • K. Nishikawa
    • 1
  1. 1.Research on Research, Pharmaceutical Research Division (ZT) and Department II of Pharmaceutical Research Laboratories I (MK, YI and KN)Takeda Chemical Industries, Ltd.Yodogawa-ku, Osaka, 532Japan

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