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Ex Vivo Expansion of Human Primitive Hemopoietic Progenitors

  • Tatsutoshi Nakahata
  • Xingwei Sui
  • Sakura Tajima
  • Kohichiro Tsuji
  • Kiyoshi Yasukawa
  • Tetsuya Taga
  • Tadamitsu Kishimoto

Abstract

The hemopoietic system is characterized by continuous cell turnover supported by a small populations of cells termed hemopoietic stem cells. It is generally held that multipotential hemopoietic stem cells possess extensive capabilities to self-renew and generate various committed progenitor cells(1). Intercellular communication in the hemopoietic system is mediated by soluble factors called cytokines, whose functional characteristics are now partly explained by their receptor system (2–5). Most cytokine receptor systems consist of a multi-chain complex, a ligand-specific receptor chain (α-chain) and a signal transducing chain (β-chain), the latter of which is often utilized in common by several receptor complexes(2,6).

Keywords

Human CD34 Hemopoietic Stem Cell Hemopoietic Progenitor Hemopoietic System Signal Transduce Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • Tatsutoshi Nakahata
    • 1
  • Xingwei Sui
    • 2
  • Sakura Tajima
    • 2
  • Kohichiro Tsuji
    • 2
  • Kiyoshi Yasukawa
    • 3
  • Tetsuya Taga
    • 4
  • Tadamitsu Kishimoto
    • 5
  1. 1.Department of Clinical Oncology, The Institute of Medical ScienceThe University of TokyoMinato-ku Tokyo 108Japan
  2. 2.Department of Clinical Oncology The Institute of Medical ScienceThe University of TokyoMinato-ku Tokyo 108Japan
  3. 3.Biotechnology Research LaboratoryTOSOH CorporationAyase, Kanagawa 252Japan
  4. 4.Institute for Molecular and Cellular BiologyOsaka UniversitySuita, Osaka 565Japan
  5. 5.Department of Medicine IIIOsaka University Medical SchoolSuita, Osaka 565Japan

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