Skip to main content
SpringerLink
Log in

Antileukemic Effects of Interleukin 2 after Allogeneic Bone Marrow Transplantation in AKR/J Mice

  • Conference paper
Bone Marrow Transplantation

  • 91 Accesses

Summary

AKR/J mice show a high incidence of spontaneous virus-induced T cell leukemiaat the age of 6-12 months, and a number of factors are involved in the high susceptibility to leukemiadevelopment. The present study was designed to examine whether a combination of interleukin2 (IL-2), which has a strong immunostimulatingpotential, and bone marrow transplantation(BMT) from allogeneic C3H/HeJ mice sensitive to the virus and allogeneicCBA/J mice resistant to the virus could induce resistance against the developmentof spontaneous leukemiaand exacerbate graft-versus-host disease (GVHD). Our data suggested that BMT from H-2 compatiblemice that did not possess a resistant gene for virus-induced leukemiaand a combined use of IL-2 after BMT could partially prevent the developmentof spontaneous leukemiain chimericAKR/J mice. The GVHD observed in chimeric mice was not enhanced by the administrationof IL-2.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. McEndy DP, Boon MC, Furth J. On the role of thymus, spleen, and gonads in the development of leukemia in a high-leukemia stock of mice. Cancer Res 1944; 4: 377.

    Google Scholar 

  2. Yasumizu R, Hiai H, Sugiura K, et al. Development of donor-derived thymic lymphomas after allogeneic bone marrow transplantation in AKR/J mice. J Immunol 1988; 141: 2181.

    Google Scholar 

  3. Pollard M, Truitt RL. Allogeneic bone marrow chimerism in germfree mice. 1. Prevention of spontaneous leukemia in AKR mice. Proc Soc Exp Biol Med 1973; 144: 659.

    PubMed  CAS  Google Scholar 

  4. Tanaka T, Obata Y, Fernandes G, Onoe K, Stockert E, Good RA. Prevention of leukemia in lethally irradiated AKR mice by CBA/H marrow transplantation. Proc Am Assoc Cancer Res 1979; 20: 114.

    Google Scholar 

  5. Wustrow TPU, Good RA. Expression of antigens coded in mutine leukemia viruses on thymocytes of allogeneic donor origin in AKR mice following syngeneic or allogeneic bone marrow transplantation. Cancer Res 1985; 45: 6428.

    PubMed  CAS  Google Scholar 

  6. Sykes M, Romick ML, Sachs DH. Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cells. Proc Natl Acad Sci USA 1990; 87: 5633.

    Article  PubMed  CAS  Google Scholar 

  7. Ackerstein A, Kedar E, Slavin S. Use of recombinant human interleukin-2 in conjunction with syngeneic bone marrow transplantation in mice as a model for control of minimal residual disease in malignant hematologic disorders. Blood 1991; 78: 1212.

    PubMed  CAS  Google Scholar 

  8. Kwak LW, Campbell MJ, Levy R. Tumor resistance induced by syngeneic bone marrow transprantation and enhanced by interleukin 2: A model for the graft versus leukemia reaction. Cancer Res 1992; 52: 4117.

    PubMed  CAS  Google Scholar 

  9. Hashino S. (1994) Antileukemic effects of interleukin-2 on spontaneous development of leukemia after H-2-compatible allogeneic bone marrow transplantation in AKR/J mice. Hokkaido J Med Sci 69: 601–613

    PubMed  CAS  Google Scholar 

  10. Hashino S, Imamura M, Zhu X, Imai K, Kobayashi S, Tanaka J, Fujii Y, Kasai M, Miyazaki T. (1995) Effects of interleukin 2 on leukemia development after bone marrow transplantation in AKR/J mice. Transplantation 59: 1643–1645

    Google Scholar 

  11. Heslop HE, Gottlieb DJ, Bianchi ACM, et al. In vivo induction of gamma interferon and tumor necrosis factor by interleukin-2 infusion following intensive chemotherapy or autologous marrow transplantation. Blood 1989; 74: 1374.

    Google Scholar 

  12. Tanaka J, Imamura M, Kasai M, et al. Cytokine gene expression in peripheral blood mononuclear cells during graft-verus-host disease after allogeneic bone marrow transplantation. Br J Haematol 1993; 85: 558.

    Article  PubMed  CAS  Google Scholar 

  13. Imamura M, Hashino S, Kobayashi H, et al. Serum cytokine levels in bone marrow transplantation: Synergistic interaction of interleukin-6, interferon-γ, and tumor necrosis factor-α in graft-versus-host disease. Bone Marrow Transplant 1994; 13: 745.

    PubMed  CAS  Google Scholar 

  14. Takikawa O, Oku T, Yasui H, Yoshida R. Synergism between IFN-γ and IL-lα/β in growth inhibition of an allografted tumor. J Immunol 1993; 151: 2070.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Third Department of Internal Medicine, Hokkaido University School of Medicine, Kita-15 Nishi-7, Kita-ku, Sapporo 060, Japan

    Satoshi Hashino, Masahiro Imamura, Junji Tanaka, Sumiko Kobayashi & Masahiro Asaka

  2. Division of Internal Medicine, Sapporo Hokuyu Hospital, 6-6 Higashi-Sapporo, Shiroishi-ku, Sapporo 003, Japan

    Masaharu Kasai

Authors
  1. Satoshi Hashino
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masahiro Imamura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Junji Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sumiko Kobayashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Masaharu Kasai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Masahiro Asaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570, Japan

    Susumu Ikehara M.D., Ph.D. (Professor) (Professor)

  2. International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Fumimaro Takaku M.D., Ph.D. (President) (President)

  3. Department of Pediatrics, All Children’s Hospital, University of South Florida, 801 Sixth Street South, Box 753, St. Petersburg, FL, 33701, USA

    Robert A. Good M.D., Ph.D., D.Sc., FACP (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology) (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Hashino, S., Imamura, M., Tanaka, J., Kobayashi, S., Kasai, M., Asaka, M. (1996). Antileukemic Effects of Interleukin 2 after Allogeneic Bone Marrow Transplantation in AKR/J Mice. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_35

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68320-9_35

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68322-3

  • Online ISBN: 978-4-431-68320-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation