Skip to main content
SpringerLink
Log in

Transplantation with Purified or Unmanipulated Mobilized Blood Stem Cells in Children

  • Conference paper
Bone Marrow Transplantation

  • 95 Accesses

Summary

Experience of collection and transplant of peripheral blood stem cells (PBSC) was evaluated in children with active cancer. We found that the procedure is effective and safe. Preliminary therapeutic results of autografts with PBSC for children with acute leukemias or solid tumors are encouraging. A well-designed clinical protocol for PBSCT could provide an efficient and realistic stage for future evaluation of the potential of forthcoming cytokines in the field of cancer medicine. Moreover, an effective and relatively tumor-free form of hematopoietic support for cancer patients undergoing myeloablative chemotherapy (“indirect purging”) may be possible through the use of purified CD34+ cells. We predict that its role outside of cancer therapy will continue to evolve.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Takaue Y, Watanabe T, Abe T, Hirao A, Okamoto Y, Saito S, Shimizu T, Sato J, Suzue T, Koyama T, Kawano Y, Ninomiya T, Shimokawa T, Yokobayashi A, Kuroda Y (1992) Experience with peripheral blood stem cell collection for autografts in children with active cancer. Bone Marrow Transplant 10: 241–248.

    PubMed  CAS  Google Scholar 

  2. Takaue Y (1993) Collection of peripheral blood stem cells for autografts in children with cancer. In: Henon P, Wunder E (eds) Peripheral Blood Stem Cell Autografts. Springer-Verlag, Berlin, pp 194–198.

    Chapter  Google Scholar 

  3. Takaue Y, Kawano Y, Abe T, Okamoto Y, Suzue T, Saito S, Sato J, Watanabe T, Ito M, Kuroda Y (1995) Collection and transplant of peripheral blood stem cells in very small children weighing 20 kg or less. Blood 86: 372–380.

    PubMed  CAS  Google Scholar 

  4. Kawano Y, Takaue Y, Watanabe T, Saito S, Hirao A, Abe T, Sato J, Ninomiya T, Shimokawa T, Yokobayashi A, Asano S, Masaoka T, Takaku F, Kuroda Y (1993) Effects of progenitor cell dose and preleukapheresis use of human recombinant granulocyte colony-stimulating factor on the recovery of hematopoiesis after blood stem cell autografting in children. Exp Hematol 21: 103–108.

    PubMed  CAS  Google Scholar 

  5. Takaue Y, Kawano Y, Kuroda Y (1995) Mobilization of peripheral blood stem cells for autografts. In: Levit DJ, Mertelsmann R (eds) Hematopoietic Stem Cells: Biology and Therapeutic Applications. Marcel Dekker, New York, pp 611–630.

    Google Scholar 

  6. Takaue Y (1993) Peripheral blood stem cell autografts for the treatment of childhood cancer: A review of Japanese experience. J Hematother 2: 513–518.

    Article  PubMed  CAS  Google Scholar 

  7. Takaue Y, Watanabe A, Watanabe T, Okamoto Y, Saito S, Abe T, Suzue T, Shimizu T, Sato J, Kawano Y, Kuroda Y, Murakami T, Eguchi H, Matsushita T, Kikuta A, Shimokawa T, lwai A, Kosaka Y, Murakami R, Mimaya J, Shimizu H, Koizumi S, Fujimoto T (1994) High-dose chemotherapy and blood stem cell autografts for children with first relapsed acute lymphoblastic leukemia: A report from the Children’s Cancer and Leukemia Study Group of Japan ( CCLSG ). Med Pediatr Oncol 23: 20–25.

    Google Scholar 

  8. Eguchi H, Takaue Y (1994) Peripheral blood stem cell autografts in the treatment of pediatric solid tumors. In: Dicke KA, Keating A (eds) Autologous Marrow and Blood Transplantation. The Cancer Treatment Research and Educational Institute, Arlington, pp 597–606.

    Google Scholar 

  9. Takaue Y, Abe T, Kawano Y, Suzue T, Saito S, Hirao A, Sato J, Makimoto A, Kawahito M, Watanabe T, Shimokawa T, Kuroda Y (1994) et al: Comparative analysis of engraftment after peripheral blood stem cell autografts cryopreserved by controlled vs uncontrolled-rate method. Bone Marrow Transplant 13: 801–804.

    Google Scholar 

  10. Suzue T, Takaue Y, Watanabe A, Kawano Y, Watanabe T, Abe T, Kuroda Y, Matsushita T, Kikuta A, Iwai A, Shimokawa T, Eguchi H, Murakami T, Kosaka Y, Kudo T, Shimizu H, Koizumi S, Fujimoto T (1994) Effects of recombinant human granulocyte colony-stimulating factor (filgrastim) on the recovery of hematopoiesis after high-dose chemotherapy and autologous peripheral blood stem cell transplantation in children: a report from the Children’s Cancer and Leukemia Study Group of Japan ( CCLSG ). Exp Hematol 22: 1197–1202.

    Google Scholar 

  11. Okamoto Y, Takaue Y, Saito S, Hirao A, Shimizu T, Suzue T, Abe T, Sato J, Watanabe T, Kawano Y, Kuroda Y (1993) Toxicities associated with infusion of cryopreserved and thawed peripheral blood stem cell autografts in children with active cancer. Transfusion 33: 578–581.

    Article  PubMed  CAS  Google Scholar 

  12. Suzue T, Kawano Y, Takaue Y, Kuroda Y (1994) Cell processing protocol for allogeneic peripheral blood stem cells mobilized by granulocyte colony-stimulating factor. Exp Hematol. 22: 888–892.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Tokushima, Kuramoto-cho, Tokushima 770, Japan

    Yoichi Takaue, Yoshifumi Kawano, Takanori Abe, Atsushi Makimoto, Yasuhiro Okamoto & Yasuhiro Kuroda

  2. University of Akita, Honmichi, Akita 010, Japan

    Arata Watanabe

  3. Kurume University, Asahimachi, Kurume 830, Japan

    Haruhiko Eguchi

Authors
  1. Yoichi Takaue
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yoshifumi Kawano
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arata Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Haruhiko Eguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takanori Abe
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Atsushi Makimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yasuhiro Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yasuhiro Kuroda
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka, 570, Japan

    Susumu Ikehara M.D., Ph.D. (Professor) (Professor)

  2. International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162, Japan

    Fumimaro Takaku M.D., Ph.D. (President) (President)

  3. Department of Pediatrics, All Children’s Hospital, University of South Florida, 801 Sixth Street South, Box 753, St. Petersburg, FL, 33701, USA

    Robert A. Good M.D., Ph.D., D.Sc., FACP (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology) (Distinguished Research Professor, University of South Florida, Head of Allergy and Clinical Immunology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Tokyo

About this paper

Cite this paper

Takaue, Y. et al. (1996). Transplantation with Purified or Unmanipulated Mobilized Blood Stem Cells in Children. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_30

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-68320-9_30

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68322-3

  • Online ISBN: 978-4-431-68320-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation