Summary
Further improvements in the safety and efficacy of unrelated donor transplants can be expected with better GVHD prevention and facilitation of tolerance induction. New approaches such as selected depletion of distinct T cell subsets, use of purified stem cells and novel forms of immune modulation using biologicals and other engineered molecules are promising, but additional preclinical and appropriate clinical trials must be undertaken before the full potential benefits as well as limitations of these new approaches are known.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Thomas ED: The Nobel Lectures in Immunology. The Nobel Prize for Physiology of Medicine, 1990. Bone marrow transplantation–past, present and future. Scand J Immunol 39: 339–345, 1994.
Good RA: Bone marrow transplantation: cellular engineering to correct primary immunodeficiency, are generative anemia and pancytopenia. Birth Defects 11: 377–379, 1975
Beatty PG, Clift RA, Mickelson EM, Nisperos BN, Floumoy N, Martin PJ, Sanders JE, Stewart P, Buckner CD, Storb R, Thomas ED, Hansen JA: Marrow transplantation from related donors other than HLA-identical siblings. N. Engl. J. Med. 313: 765–771, 1985.
Anasetti C, Amos D, Beatty PG, Appelbaum FR, Bensinger W, Buckner CD, Clift R, Doney K, Martin PJ, Mickelson E, Nisperos BN, O’Quigley J, Ramberg R, Sanders JE, Stewart P, Storb R, Sullivan KM, Witherspoon RP, Thomas ED, Hansen JA: Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N. Engl. J. Med. 320: 197–204, 1989.
Anasetti C, Beatty PG, Storb R, Martin. PJ, Mori, M., Sanders JE, Thomas ED, Hansen JA: Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. Hum.Immunol. 29: 79–91, 1990.
Anasetti C, Hansen J: Bone marrow transplantation from HLA-partially matched related donors and unrelated volunteer donors. In: Forman SJ, Blume KG, Thomas ED (eds) Bone Marrow Transplantation. Blackwell Scientific Publications, Cambridge, MA, pp. 665–679, 1993
McCullough J, Hansen J, Perkins H, Stroncek D, Bartsch G: The National Marrow Donor Program: How it works, accomplishments to date. Oncology 3: 63–74, 1989.
Stroncek D, Bartsch G, Perkins HA, Randall BL, Hansen JA, McCullough J: The National Marrow Donor Program. Transfusion 33: 567–577, 1993.
Stroncek, D.F., Holland, P.V., Bartch, G., Bixby, T., Simmons, R.G., Antin, J.H., Anderson, K.C., Ash, R.C., Bolwell, B.J., Hansen JA, Heal, J.M., Henslee-Downey, P.J., Jaffé, E.R., Klein, H.G., Lau, P.M., Perkins, H.A., Popovsky, M.A., Price, T.H., Rowley, S.D., Stehling, L.C., Weiden PL, Wissel, M.E., McCullough, J.: Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program. Blood 81: 1940–1946, 1993.
Petersdorf EW, Smith AG, Mickelson EM, Martin PJ, Hansen JA: Ten HLADR4 alleles defined by sequence polymorphisms within the DRB I first domain. Immunogenetics 33: 267–275, 1991.
Petersdorf EW, Longton GM, Anasetti C, Martin PJ, Mickelson EM, Smith AG, Hansen JA: The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood 86: 1606–1613, 1995.
Petersdorf EW, Smith AG, Mickelson EM, Longton G, Anasetti C, Choo YC, Martin PJ, Hansen JA: The influence of HLA-DPB 1 disparity on the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Trans Proc 25: 1230–1231, 1993.
Mickelson EM, Longton G, Anasetti C, Petersdorf E, Martin PJ, Guthrie LA, Hansen JA: Evaluation of the mixed lymphocyte culture (MLC) assay as a method for selecting unrelated donors for marrow transplantation. (in press, Tissue Antigens 7/95).
Petersdorf EW, Setoda T, Smith AG, Hansen JA: Analysis of HLA-B*44 alleles encoded on extended HLA haplotypes by direct automated sequencing. Tissue Antigens 44: 211–216, 1994.
Petersdorf EW, Stanley JF, Martin PJ, Hansen JA. Molecular diversity of the HLA-C locus in unrelated marrow transplantation. Tissue Antigens 1994; 44: 93–9.
Petersdorf EW, Hansen JA. A comprehensive approach for typing the alleles of the HLA-B locus by automated sequencing. Tissue Antigens 1995; 46: 73–85.
Petersdorf EW, Longton G, Anasetti C, Smith AG, McKinney S, Martin PJ, Hansen JA: Donor-recipient disparity for HLA-C genes is a risk factor for graft failure following marrow transplantation from unrelated donors. Blood 86: 291a, 1995.
Balduzzi A, Gooley T, Anasetti C, Sanders JE, Martin PJ, Petersdorf EW, Appelbaum FR, Buckner CD, Matthews D, Storb R, Sullivan KM, Hansen JA: Unrelated donor marrow transplantation in children. Blood 86: 3247–3256, 1995.
Sierra J, Storer B, Hansen J, Martin P, Petersdorf E, Appelbaum E, Buckner D, Sale G, Sanders J, Anasetti: Unrelated donor marrow transplants for acute leukemia. Blood 86: 290a, 1995.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Tokyo
About this paper
Cite this paper
Hansen, J.A., Sierra, J., Petersdorf, E.W., Martin, P.J., Anasetti, C. (1996). Hematopoietic Stem Cell Transplants from Unrelated Donors. In: Ikehara, S., Takaku, F., Good, R.A. (eds) Bone Marrow Transplantation. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68320-9_29
Download citation
DOI: https://doi.org/10.1007/978-4-431-68320-9_29
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68322-3
Online ISBN: 978-4-431-68320-9
eBook Packages: Springer Book Archive