Hematopoietic Stem Cell Transplants from Unrelated Donors

  • John A. Hansen
  • Jorge Sierra
  • Effie W. Petersdorf
  • Paul J. Martin
  • Claudio Anasetti
Conference paper


Further improvements in the safety and efficacy of unrelated donor transplants can be expected with better GVHD prevention and facilitation of tolerance induction. New approaches such as selected depletion of distinct T cell subsets, use of purified stem cells and novel forms of immune modulation using biologicals and other engineered molecules are promising, but additional preclinical and appropriate clinical trials must be undertaken before the full potential benefits as well as limitations of these new approaches are known.


Chronic Myeloid Leukemia Acute GVHD Chronic GVHD Unrelated Donor Mixed Lymphocyte Culture 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Thomas ED: The Nobel Lectures in Immunology. The Nobel Prize for Physiology of Medicine, 1990. Bone marrow transplantation–past, present and future. Scand J Immunol 39: 339–345, 1994.PubMedCrossRefGoogle Scholar
  2. 2.
    Good RA: Bone marrow transplantation: cellular engineering to correct primary immunodeficiency, are generative anemia and pancytopenia. Birth Defects 11: 377–379, 1975PubMedGoogle Scholar
  3. 3.
    Beatty PG, Clift RA, Mickelson EM, Nisperos BN, Floumoy N, Martin PJ, Sanders JE, Stewart P, Buckner CD, Storb R, Thomas ED, Hansen JA: Marrow transplantation from related donors other than HLA-identical siblings. N. Engl. J. Med. 313: 765–771, 1985.PubMedCrossRefGoogle Scholar
  4. 4.
    Anasetti C, Amos D, Beatty PG, Appelbaum FR, Bensinger W, Buckner CD, Clift R, Doney K, Martin PJ, Mickelson E, Nisperos BN, O’Quigley J, Ramberg R, Sanders JE, Stewart P, Storb R, Sullivan KM, Witherspoon RP, Thomas ED, Hansen JA: Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N. Engl. J. Med. 320: 197–204, 1989.PubMedCrossRefGoogle Scholar
  5. 5.
    Anasetti C, Beatty PG, Storb R, Martin. PJ, Mori, M., Sanders JE, Thomas ED, Hansen JA: Effect of HLA incompatibility on graft-versus-host disease, relapse, and survival after marrow transplantation for patients with leukemia or lymphoma. Hum.Immunol. 29: 79–91, 1990.PubMedCrossRefGoogle Scholar
  6. 6.
    Anasetti C, Hansen J: Bone marrow transplantation from HLA-partially matched related donors and unrelated volunteer donors. In: Forman SJ, Blume KG, Thomas ED (eds) Bone Marrow Transplantation. Blackwell Scientific Publications, Cambridge, MA, pp. 665–679, 1993Google Scholar
  7. 7.
    McCullough J, Hansen J, Perkins H, Stroncek D, Bartsch G: The National Marrow Donor Program: How it works, accomplishments to date. Oncology 3: 63–74, 1989.PubMedGoogle Scholar
  8. 8.
    Stroncek D, Bartsch G, Perkins HA, Randall BL, Hansen JA, McCullough J: The National Marrow Donor Program. Transfusion 33: 567–577, 1993.PubMedCrossRefGoogle Scholar
  9. 9.
    Stroncek, D.F., Holland, P.V., Bartch, G., Bixby, T., Simmons, R.G., Antin, J.H., Anderson, K.C., Ash, R.C., Bolwell, B.J., Hansen JA, Heal, J.M., Henslee-Downey, P.J., Jaffé, E.R., Klein, H.G., Lau, P.M., Perkins, H.A., Popovsky, M.A., Price, T.H., Rowley, S.D., Stehling, L.C., Weiden PL, Wissel, M.E., McCullough, J.: Experiences of the first 493 unrelated marrow donors in the National Marrow Donor Program. Blood 81: 1940–1946, 1993.PubMedGoogle Scholar
  10. 10.
    Petersdorf EW, Smith AG, Mickelson EM, Martin PJ, Hansen JA: Ten HLADR4 alleles defined by sequence polymorphisms within the DRB I first domain. Immunogenetics 33: 267–275, 1991.PubMedCrossRefGoogle Scholar
  11. 11.
    Petersdorf EW, Longton GM, Anasetti C, Martin PJ, Mickelson EM, Smith AG, Hansen JA: The significance of HLA-DRB1 matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood 86: 1606–1613, 1995.PubMedGoogle Scholar
  12. 12.
    Petersdorf EW, Smith AG, Mickelson EM, Longton G, Anasetti C, Choo YC, Martin PJ, Hansen JA: The influence of HLA-DPB 1 disparity on the development of acute graft-versus-host disease following unrelated donor marrow transplantation. Trans Proc 25: 1230–1231, 1993.Google Scholar
  13. 13.
    Mickelson EM, Longton G, Anasetti C, Petersdorf E, Martin PJ, Guthrie LA, Hansen JA: Evaluation of the mixed lymphocyte culture (MLC) assay as a method for selecting unrelated donors for marrow transplantation. (in press, Tissue Antigens 7/95).Google Scholar
  14. 14.
    Petersdorf EW, Setoda T, Smith AG, Hansen JA: Analysis of HLA-B*44 alleles encoded on extended HLA haplotypes by direct automated sequencing. Tissue Antigens 44: 211–216, 1994.PubMedCrossRefGoogle Scholar
  15. 15.
    Petersdorf EW, Stanley JF, Martin PJ, Hansen JA. Molecular diversity of the HLA-C locus in unrelated marrow transplantation. Tissue Antigens 1994; 44: 93–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Petersdorf EW, Hansen JA. A comprehensive approach for typing the alleles of the HLA-B locus by automated sequencing. Tissue Antigens 1995; 46: 73–85.PubMedCrossRefGoogle Scholar
  17. 17.
    Petersdorf EW, Longton G, Anasetti C, Smith AG, McKinney S, Martin PJ, Hansen JA: Donor-recipient disparity for HLA-C genes is a risk factor for graft failure following marrow transplantation from unrelated donors. Blood 86: 291a, 1995.Google Scholar
  18. 18.
    Balduzzi A, Gooley T, Anasetti C, Sanders JE, Martin PJ, Petersdorf EW, Appelbaum FR, Buckner CD, Matthews D, Storb R, Sullivan KM, Hansen JA: Unrelated donor marrow transplantation in children. Blood 86: 3247–3256, 1995.PubMedGoogle Scholar
  19. 19.
    Sierra J, Storer B, Hansen J, Martin P, Petersdorf E, Appelbaum E, Buckner D, Sale G, Sanders J, Anasetti: Unrelated donor marrow transplants for acute leukemia. Blood 86: 290a, 1995.Google Scholar

Copyright information

© Springer-Verlag Tokyo 1996

Authors and Affiliations

  • John A. Hansen
    • 1
  • Jorge Sierra
    • 1
  • Effie W. Petersdorf
    • 1
  • Paul J. Martin
    • 1
  • Claudio Anasetti
    • 1
  1. 1.Fred Hutchinson Cancer Research Center, and Department of MedicineUniversity of Washington School of MedicineSeattleUSA

Personalised recommendations