Advertisement

Current Topics in Cerebral Vasospasm

  • Eugene S. Flamm
Conference paper

Abstract

Although considerable improvement in operative mortality and morbidity has been made in the past 15 years in patients with subarachnoid hemorrhage (SAH) from cerebral aneurysms, many reports document the lack of similar improvement in case morbidity and mortality [1, 3]. A major contributing factor to the persistently high morbidity of SAH is the development of cerebral vasospasm and ischemia which leads to progressive ischemic neurological deficits during the first 5–9 days after SAH [1, 3, 4, 5]. Vasospasm is found by angiography in as many as 70% of patients, and symptomatic vasospasm develops in 20%–30% of patients following SAH. Cerebral vasospasm with secondary ischemia is the leading cause of death and disability among patients with aneurysmal SAH [9].

Keywords

Cerebral Aneurysm Cerebral Vasospasm Aneurysm Surgery Symptomatic Vasospasm Secondary Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Adams HP Jr, Kassell NF, Torner JC, Nibbelink DW, Sahs AL (1981) Early management of aneurysmal subarachnoid hemorrhage: A report of the Cooperative Aneurysm Study. J Neurosurg 54:141–145PubMedCrossRefGoogle Scholar
  2. 2.
    Clarke B, Grant D, Patmore L, Whiting RL (1983) Comparative calcium entry blocking properties of nicardipine, nifedipine and P4108068 on cardiac and vascular smooth muscle. Br J Pharmacol 79:333Google Scholar
  3. 3.
    Drake CG (1981) Management of cerebral aneurysm. Stroke 12:273–283PubMedCrossRefGoogle Scholar
  4. 4.
    Flamm ES (1986) The timing of aneurysm surgery 1985. Clin Neurosurg 33:147–158PubMedGoogle Scholar
  5. 5.
    Flamm ES (1986) Vasospasm and the timing of aneurysm surgery: Have we progressed? Neurosurg Rev 9:71–76PubMedCrossRefGoogle Scholar
  6. 6.
    Grotta J, Spydell J, Pettigrew C, Ostrow P, Hunter D (1986) The effect of nicardipine on neuronal function following ischemia. Stroke 17:213–219PubMedCrossRefGoogle Scholar
  7. 7.
    Handa J, Matsuda M, Nakasu Y, Nakasu S, Kidooka M, Watanabe K (1984) Early operation of aneurysmal subarachnoid hemorrhage use of nicardipine, a calcium channel blocker. Arch Jpn Chir 53:619–630Google Scholar
  8. 8.
    Handa J, Yoneda S, Koyama T, Matsuda M, Handa H (1975) Experimental cerebral vasospasm in cats: Modification by a new synthetic vasodilator YC-93. Surg Neurol 3:195–199PubMedGoogle Scholar
  9. 9.
    Kassell NF (1985) Cooperative study on timing of aneurysm surgery. American Association of Neurological Surgeons Annual Meeting, 23 April 1985, AtlantaGoogle Scholar
  10. 10.
    Kassell NF, Peerless SJ, Durward QJ, Beck DW, Drake CG, Adams HP (1982) Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension. Neurosurg 11:337–343CrossRefGoogle Scholar

Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Eugene S. Flamm
    • 1
  1. 1.Division of NeurosurgeryUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

Personalised recommendations