The Possible Role of Free Radical Scavengers in the Mitigation of Ischemic Brain Damage
During the past decade, a considerable research effort has been directed toward substantiation of the hypothesized role of free radicals and lipid peroxidation in the occurrence of ischemic brain damage. Regarding the enhanced generation of active oxygens and the occurrence of lipid peroxidation during or following cerebral ischemia, however, experimental results have not been consistent. Although favorable effects of some free radical scavengers on ischemic brain damage were reported by some authors, the exact mechanism of action of each drug has remained uncertain. Therefore, the theory remains controversial as yet, and it seems justified to question what the real significance of free radical mechanism is in the occurrence of ischemic brain damage.
KeywordsFree Radical Scavenger Ischemic Brain Brain Edema Ischemic Brain Damage Bilateral Common Carotid Artery Occlusion
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