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Does Glutamatergic Excitatory Synaptic Transmission Play a Role in Ischemia?

  • D. Miller
  • S. J. Peerless
Conference paper

Abstract

Glutamate and aspartate have become increasingly accepted by neurophysiologists as endogenous neurotransmitters. These acidic amino acids mediate excitatory synaptic transmission throughout the central nervous system. Three dendritic, postsynaptic receptor subtypes are known; a fourth possibly exists at a presynaptic site. The major excitatory amino acid receptors are named on the basis of specific agonist binding: N-methyl-D-aspartate (NMDA or NMA), Kainate, and Quisqualate. The non-NMDA receptors mediate fast, all-or-none excitatory transmission within glutamatergic pathways, whereas the NMDA receptors mediate such complex neurophysiological functions as long-term potentiation, memory, and learning.

Keywords

NMDA Receptor Excitatory Amino Acid Transient Cerebral Ischemia Excitatory Amino Acid Receptor NMDA Recep 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1988

Authors and Affiliations

  • D. Miller
    • 1
  • S. J. Peerless
    • 1
  1. 1.Division of NeurosurgeryThe University of Western OntarioLondonCanada

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