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Advances in Surgery for Cerebral Stroke pp 247–249Cite as

Does Glutamatergic Excitatory Synaptic Transmission Play a Role in Ischemia?

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Abstract

Glutamate and aspartate have become increasingly accepted by neurophysiologists as endogenous neurotransmitters. These acidic amino acids mediate excitatory synaptic transmission throughout the central nervous system. Three dendritic, postsynaptic receptor subtypes are known; a fourth possibly exists at a presynaptic site. The major excitatory amino acid receptors are named on the basis of specific agonist binding: N-methyl-D-aspartate (NMDA or NMA), Kainate, and Quisqualate. The non-NMDA receptors mediate fast, all-or-none excitatory transmission within glutamatergic pathways, whereas the NMDA receptors mediate such complex neurophysiological functions as long-term potentiation, memory, and learning.

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Authors and Affiliations

  1. Division of Neurosurgery, The University of Western Ontario, London, Ontario, Canada

    D. Miller & S. J. Peerless

Authors
  1. D. Miller
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  2. S. J. Peerless
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Editors and Affiliations

  1. Division of Neurosurgery, Institute of Brain Diseases, Tohoku University, School of Medicine, Sendai, 980, Japan

    Jiro Suzuki M.D

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© 1988 Springer Japan

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Miller, D., Peerless, S.J. (1988). Does Glutamatergic Excitatory Synaptic Transmission Play a Role in Ischemia?. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_46

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  • DOI: https://doi.org/10.1007/978-4-431-68314-8_46

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68316-2

  • Online ISBN: 978-4-431-68314-8

  • eBook Packages: Springer Book Archive

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