Does Glutamatergic Excitatory Synaptic Transmission Play a Role in Ischemia?
Glutamate and aspartate have become increasingly accepted by neurophysiologists as endogenous neurotransmitters. These acidic amino acids mediate excitatory synaptic transmission throughout the central nervous system. Three dendritic, postsynaptic receptor subtypes are known; a fourth possibly exists at a presynaptic site. The major excitatory amino acid receptors are named on the basis of specific agonist binding: N-methyl-D-aspartate (NMDA or NMA), Kainate, and Quisqualate. The non-NMDA receptors mediate fast, all-or-none excitatory transmission within glutamatergic pathways, whereas the NMDA receptors mediate such complex neurophysiological functions as long-term potentiation, memory, and learning.
KeywordsNMDA Receptor Excitatory Amino Acid Transient Cerebral Ischemia Excitatory Amino Acid Receptor NMDA Recep
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