Abstract
Opiates are best known for their analgesic properties, but they have many other effects on central nervous system (CNS) functions, including respiration, temperature control, and behavior. We have reported that certain opiates also may produce recovery from cerebral ischemia [1, 2, 4, 9]. Subsequent studies performed by others to confirm this finding in some [4, 9–11], although not all [6, 8], cases indicated that, in both experimental animals and in humans, opiate agonists exacerbate the symptoms of stroke, whereas opiate antagonists may prolong survival and, in some cases, ameliorate neurological deficits. Dynorphin1–13, an endogenous opioid peptide with both agonist and antagonist properties [12, 13], also has been shown to improve survival in animals [3].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Baskin DS, Hosobuchi Y (1981) Naloxone reversal of ischemic neurological deficits in man. Lancet 2:272–275
Baskin DS, Hosobuchi Y, Grevel JC (1986) Treatment of experimental stroke with opiate antagonists: Effects on neurological function, infarct size, and survival. J Neurosurg 64:99–103
Baskin DS, Hosobuchi Y, Loh HH, Lee NM (1984) Dynorphin (1’13) improves survival in cats with focal cerebral ischemia. Nature 312:551–552
Baskin DS, Kieck CF, Hosobuchi Y (1984) Naloxone reversal and morphine exacerbation of neurologic deficits secondary to focal cerebral ischemia in baboons. Brain Res 290:289–296
Brandt NJ, Terenius L, Jacobsen BB, Klinken L, Nordius A, Brandt S, Blegvad K, Yssing M (1980) Hyperendorphin syndrome in a child with necrotizing encephalomyelopathy. N Engl J Med 303:914–916
Cutler JR, Bredesen DE, Edwards R, Simon RP (1983) Failure of naloxone to reverse vascular neurological deficits. Neurology 33:1517–1518
Garzon J, Sanchez-Blazquez P, Lee NM (1984) [3H]-ethylketocyclazocine binding to mouse brain membranes: Evidence for a kappa opioid receptor type. J Pharmacol Exp Ther 231:33–37
Holoday JN, D’Amato RJ (1982) Naloxone or the TRH fail to improve neurologic deficits in gerbil models of stroke. Life Sci 31:385–392
Hosobuchi Y, Baskin DS, Woo SK (1982) Reversal of induced ischemic neurologic deficit in gerbils by the opiate antagonist naloxone. Science 215:69–71
Iselin HA, Weiss P (1981) Naloxone reversal of ischemic neurologic deficit. Lancet 2:642–643
Jovaily J, Davis JB (1982) Naloxone partially reverses neurologic deficits in some but not all stroke patients. Neurology 32:A194
Lee NM, Smith AP (1984) Possible regulatory function of dynorphin and its clinical implications. Trends Pharmacol Sci 5:108–110
Talunay FC, Jen MF, Chang JK, Loh HH, Lee NM (1981) Possible regulatory role of dynorphin on morphine and α-endorphin-induced analgesia. J Pharmacol Exp Ther 219:296–298
Weinberger J, Cohen G (1982) The differential effect of ischemia on the active uptake of dopamine and aminobutyric acid, and glutamate by brain synaptosomes. J Neurochem 38:963–968
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Japan
About this paper
Cite this paper
Hosobuchi, Y., Kuroda, H., Matsui, T. (1988). Effects of Dynorphin1−13 on Opiate Binding and Dopamine and GABA Uptake in a Cat Model of Stroke. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_45
Download citation
DOI: https://doi.org/10.1007/978-4-431-68314-8_45
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
eBook Packages: Springer Book Archive