Abstract
With the onset of profound cerebral ischemia, a complex chain of events is set into motion. If there is no intervention, irreversible damage occurs within several minutes. Although the primary insult of cerebral ischemia is a reduction in the supply of major nutrients, the depletion of cellular energy stores soon triggers a series of secondary events known as the “ischemic cascade.” However, numerous factors influence the course of cerebral ischemia, and cell death is not necessarily the inevitable outcome. A simplified scheme of the progression of cerebral ischemia, with identification of possible sites for treatment, is presented in Figs. 1–3.
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© 1988 Springer Japan
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Spetzler, R.F., Grahm, T.W., Nehls, D.G. (1988). Overview of Cerebral Ischemia: Rationale for Cerebral Protection. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_43
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DOI: https://doi.org/10.1007/978-4-431-68314-8_43
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
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