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Role of Prostacyclin, Thromboxane A2, and Leukotrienes in Experimental Cerebral Vasospasm

  • Takashi Ohmoto
  • Keiko Irie
  • Junji Yoshioka
  • Kozo Iwasa
Conference paper

Abstract

It has been reported that prostacyclin (PGI2) deficiency with a predominance of thromboxane A2 (TXA2) might be involved in the development of cerebral vasospasm following subarachnoid hemorrhage [1]. Recent advances in the research into other forms of arachidonic acid cascades have disclosed the biological properties of leukotrienes (LT), 5-hydroxygenase products of arachidonic acids [7]. Both LTC4 and LTD4 have been reported to have a dose-dependent constrictive action on pial arteries in mice [6], suggesting that they might be involved in the development of cerebral vasospasm. The purpose of this study is to clarify the role of eicosanoids, including PGI2, TXA2, and 5-lipoxygenäse products in experimental cerebral vasospasm.

Keywords

Arachidonic Acid Platelet Aggregation Topical Application Basilar Artery Cerebral Vasospasm 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Takashi Ohmoto
    • 1
  • Keiko Irie
    • 1
  • Junji Yoshioka
    • 1
  • Kozo Iwasa
    • 1
  1. 1.Department of Neurological SurgeryKagawa Medical SchoolKagawaJapan

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