Role of Prostacyclin, Thromboxane A2, and Leukotrienes in Experimental Cerebral Vasospasm
It has been reported that prostacyclin (PGI2) deficiency with a predominance of thromboxane A2 (TXA2) might be involved in the development of cerebral vasospasm following subarachnoid hemorrhage . Recent advances in the research into other forms of arachidonic acid cascades have disclosed the biological properties of leukotrienes (LT), 5-hydroxygenase products of arachidonic acids . Both LTC4 and LTD4 have been reported to have a dose-dependent constrictive action on pial arteries in mice , suggesting that they might be involved in the development of cerebral vasospasm. The purpose of this study is to clarify the role of eicosanoids, including PGI2, TXA2, and 5-lipoxygenäse products in experimental cerebral vasospasm.
KeywordsArachidonic Acid Platelet Aggregation Topical Application Basilar Artery Cerebral Vasospasm
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