Abstract
It has been reported that prostacyclin (PGI2) deficiency with a predominance of thromboxane A2 (TXA2) might be involved in the development of cerebral vasospasm following subarachnoid hemorrhage [1]. Recent advances in the research into other forms of arachidonic acid cascades have disclosed the biological properties of leukotrienes (LT), 5-hydroxygenase products of arachidonic acids [7]. Both LTC4 and LTD4 have been reported to have a dose-dependent constrictive action on pial arteries in mice [6], suggesting that they might be involved in the development of cerebral vasospasm. The purpose of this study is to clarify the role of eicosanoids, including PGI2, TXA2, and 5-lipoxygenäse products in experimental cerebral vasospasm.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Boullin DJ (1980) Cerebral vasospasm. Wiley, Chichester
Grady PA, Blaumanis OR, Nelson ER (1980) Morphology and flow dynamics of focal arterial constriction. In: Wilkins, RH (ed) Cerebral arterial spasm. Williams and Wilkins, Baltimore, pp 107–112
Kapp JP, Neil WR, Neil CL, et al. (1982) The three phases of vasospasm. Surg Neurol 18:40–45
Kiwak KJ, Moskowitz MA, Levin L, et al. (1985) Leukotriene production in gerbil brain after ischemic insult, subarachnoid hemorrhage, and concussive injury. J Neurosurg 62:865–869
Piper PJ, Letts LG, Galton SA (1983) Generation of a leukotriene-like substance from porcine vascular and other tissues. Prostaglandins 25:591–599
Rosenblum WI (1985) Constricting effect of leukotrienes on cerebral arterioles of mice. Stroke 16:262–263
Walker V, Pickard JD (1985) Prostaglandins, thromboxane, leukotrienes and the cerebral circulation in health and disease. In: Symon L, et al. (eds) Advances and technical standards in neurosurgery. Springer, Vienna, vol. 12, pp 3–90
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Japan
About this paper
Cite this paper
Ohmoto, T., Irie, K., Yoshioka, J., Iwasa, K. (1988). Role of Prostacyclin, Thromboxane A2, and Leukotrienes in Experimental Cerebral Vasospasm. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_132
Download citation
DOI: https://doi.org/10.1007/978-4-431-68314-8_132
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
eBook Packages: Springer Book Archive