Advertisement

Preventive Action of Cisternal Heparin Injection for Vasoconstriction After Experimental Subarachnoid Hemorrhage

  • Masahiro Asada
  • Kazuhiko Ishida
  • Norihiko Tamaki
  • Satoshi Matsumoto
  • Kieth Baker
  • John W. Peterson
  • Nicholas T. Zervas

Summary

We investigated the action of heparin in reducing the degree of vasoconstriction in the experimantal subarachnoid hemorrhage (SAH) models of rabbits. Heparin, injected intrathecally, reduced the degree of constriction significantly. On the other hand, systemic heparin injection or physiological saline cisternal injection did not reveal any preventive effect on constriction. From this experiment, we suppose that heparin might neutralize thrombin which was activated in the CSF after SAH and considered to be one of the constrictive factors producing vasospasm.

Keywords

Vertebral Artery Basilar Artery Cerebral Vasospasm Arterial Smooth Muscle Cell Nontreated Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Baker KF, Zervas NT, Pile-Spellman J, Vacanti FX, Miller D (1987) Angiographic evidence of basilar artery constriction in the rabbits: A new model of vasospasm. Surg Neurol 27:107–112PubMedCrossRefGoogle Scholar
  2. 2.
    Berk BC, Alexander RW, Brock TA, Gimbrone MA, Webb RC (1986) Vasoconstriction: A new activity for platelet-derived growth factor. Science 232:87–90PubMedCrossRefGoogle Scholar
  3. 3.
    Haver VM, Namm DH, (1984) Characterization of the thrombin-induced contraction of vascular smooth muscle. Blood Vessels 21:53–63PubMedGoogle Scholar
  4. 4.
    Kapp JP, Clower BR, Azar FM, Yabuno N, Smith RR (1985) Heparin reduces proliferative angiopathy following subarachnoid hemorrhage in cats. J Neurosurg 62:570–575PubMedCrossRefGoogle Scholar
  5. 5.
    Kasuya H, Shimizu T, Okada T, Takahashi K, Summerville T, Kitamura K (1986) Coagulation and fibrinolytic system and bradykinin in the subarachnoid space after subarachnoid hemorrhage. Blood Vessel (Jpn) 17:233–241CrossRefGoogle Scholar
  6. 6.
    Lough J, Moore S (1975) Endothelial injury induced by thrombin or thrombi. Lab Invest 33:130–135PubMedGoogle Scholar
  7. 7.
    White RP, Hagen AA, Morgan H, Dawson WN, Robertoson JT (1975) Experimental study on the genesis of cerebral vasospasm. Stroke 6:52–57PubMedCrossRefGoogle Scholar
  8. 8.
    White RP, Chapleau CE, Dugdale M, Robertson JT (1980) Cerebral arterial contractions induced by human and bovine thrombin. Stroke 11:363–368PubMedCrossRefGoogle Scholar
  9. 9.
    White RP, Robertson JT (1985) Role of plasmin, thrombin, and antithrombin III as etiological factors in delayed cerebral vasospasm. Neurosurgery 16:27–35PubMedCrossRefGoogle Scholar
  10. 10.
    White RP (1987) Comparison of the inhibitory effects of antithrombin III, α2-macroglobulin, and thrombin in human basilar arteries: Relevance to cerebral vasospasm. J Cereb Blood Flow Metab 7:68–73PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Masahiro Asada
    • 1
  • Kazuhiko Ishida
    • 1
  • Norihiko Tamaki
    • 1
  • Satoshi Matsumoto
    • 1
  • Kieth Baker
    • 2
  • John W. Peterson
    • 2
  • Nicholas T. Zervas
    • 2
  1. 1.Department of NeurosurgeryKobe UniversityKobeJapan
  2. 2.Service of Neurosurgery, Massachusetts General HospitalHarvard Medical SchoolMassachusettsUSA

Personalised recommendations