Sequential Changes of Brain Metabolism During Temporary Global Ischemia in the Rat Detected by Simultaneous 1H and 31P MRS
In vivo magnetic resonance spectroscopy (MRS) provides a noninvasive method for evaluating brain metabolism. Previous studies with 31P MRS have developed techniques for continuous monitoring of phosphate metabolites and intracellular pH (pHi) during ischemia and reperfusion . Furthermore, recent progress has made it possible to monitor brain lactate content quantitatively with 1H MRS . In this study, we utilized a double-tuned surface coil for 1H and 31P MRS. With this recently described method, in vivo 1H and 31P spectroscopy can be carried out simultaneously without retuning or replacement of the coil .
KeywordsNuclear Magnetic Resonance Spectroscopy Brain Energy Metabolism Complete Ischemia Incomplete Ischemia Acetyl Aspartate
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- 3.Chang LH, Chew WM, Weinstein PR, et al. (1987) A balanced-matched double-tuned probe for in vivo 1H and 31P NMR. J Magn Reson 72:168–172Google Scholar
- 4.Gonzalez-Mendez R, Litt L, Koretsky AP, et al. (1984) Comparison of 31P NMR spectra of in vivo rat brain using convolution difference and saturation with a surface coil: Source of the broad component in the brain spectrum. J Magn Reson 57:526–533Google Scholar