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Sequential Changes of Brain Metabolism During Temporary Global Ischemia in the Rat Detected by Simultaneous 1H and 31P MRS

  • Reizo Shirane
  • Lee-Hong Chang
  • Philip R. Weinstein
  • Thomas L. James

Abstract

In vivo magnetic resonance spectroscopy (MRS) provides a noninvasive method for evaluating brain metabolism. Previous studies with 31P MRS have developed techniques for continuous monitoring of phosphate metabolites and intracellular pH (pHi) during ischemia and reperfusion [1]. Furthermore, recent progress has made it possible to monitor brain lactate content quantitatively with 1H MRS [2]. In this study, we utilized a double-tuned surface coil for 1H and 31P MRS. With this recently described method, in vivo 1H and 31P spectroscopy can be carried out simultaneously without retuning or replacement of the coil [3].

Keywords

Nuclear Magnetic Resonance Spectroscopy Brain Energy Metabolism Complete Ischemia Incomplete Ischemia Acetyl Aspartate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Reizo Shirane
    • 1
  • Lee-Hong Chang
    • 1
    • 2
  • Philip R. Weinstein
    • 1
  • Thomas L. James
    • 2
  1. 1.Department of NeurosurgeryUniversity of CaliforniaSan FranciscoUSA
  2. 2.Department of Pharmaceutical ChemistryUniversity of CaliforniaSan FranciscoUSA

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