Abstract
In vivo magnetic resonance spectroscopy (MRS) provides a noninvasive method for evaluating brain metabolism. Previous studies with 31P MRS have developed techniques for continuous monitoring of phosphate metabolites and intracellular pH (pHi) during ischemia and reperfusion [1]. Furthermore, recent progress has made it possible to monitor brain lactate content quantitatively with 1H MRS [2]. In this study, we utilized a double-tuned surface coil for 1H and 31P MRS. With this recently described method, in vivo 1H and 31P spectroscopy can be carried out simultaneously without retuning or replacement of the coil [3].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Andrews BT, Keniry MA, Richards TR, et al. (1987) 31-phosphorus nuclear magnetic resonance spectroscopy in global cerebral ischemia and reperfusion in the rat. Neurosurgery 5:699–708
Chang LH, Pereira BM, Keniry MA, et al. (1987) Comparison of lactate concentration determinations in ischemic and hypoxic rat brains by in vivo and in vitro 1H NMR spectroscopy. Magn Reson Med 4:575–581
Chang LH, Chew WM, Weinstein PR, et al. (1987) A balanced-matched double-tuned probe for in vivo 1H and 31P NMR. J Magn Reson 72:168–172
Gonzalez-Mendez R, Litt L, Koretsky AP, et al. (1984) Comparison of 31P NMR spectra of in vivo rat brain using convolution difference and saturation with a surface coil: Source of the broad component in the brain spectrum. J Magn Reson 57:526–533
von Hanwehr R, Smith ML, Siesjo BK (1986) Extra-and intracellular pH during near-complete forebrain ischemia in the rat. J Neurochem 46:331–339
Kameyama M, Suzuki J, Shirane R, et al. (1985) A new model of bilateral hemispheric ischemia in the rat: Three-vessel occlusion model. Stroke 16:489–493
Ljunggren B, Norberg K, Siesjo BK (1974) Influence of tissue acidosis upon restitution of brain energy metabolism following total ischemia. Brain Res 77:173–186
Petroff OAC, Prichard JW, Behar KL, et al. (1985) Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 35:781–788
Seo Y, Murakami M, Watari H, et al. (1983) Intracellular pH determination by a 31P NMR technique: The second dissociation constant of phosphoric acid in a biological system. J Biochem 94:729–734
Yoshida S, Busto R, Martinez, et al. (1985) Regional brain energy metabolism after complete versus incomplete ischemia in the rat in the absence of severe lactic acidosis. J Cereb Blood Flow Metabol 5:490–501
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Japan
About this paper
Cite this paper
Shirane, R., Chang, LH., Weinstein, P.R., James, T.L. (1988). Sequential Changes of Brain Metabolism During Temporary Global Ischemia in the Rat Detected by Simultaneous 1H and 31P MRS. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_117
Download citation
DOI: https://doi.org/10.1007/978-4-431-68314-8_117
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
eBook Packages: Springer Book Archive