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The Effect of Mannitol, Nimodipine, and Indomethacin, Singly or in Combination, on Cerebral Ischemia

  • Garnette Sutherland
  • Howard Lesiuk
  • Ranjan Bose
  • Anders A. F. Sima
Conference paper

Abstract

The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats (divided equally into nine groups) subjected to 10 min of forebrain ischemia. Of two control groups, one received maintenance fluids, while the other, a normal saline bolus. In the remaining seven groups, mannitol, nimodipine, and indomethacin were administered either singly or in combination 5 min prior to forebrain ischemia. Seven days postischemia, the brains were perfusion-fixed, sectioned coronally into 2.8-mm slices, and stained with hematoxylin and eosin. Quantification of dying neurons was performed by direct counting of standardized levels chosen from the serial sections.

Keywords

Ischemic Injury Neuronal Injury Ischemic Insult Cereb Blood Flow Forebrain Ischemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Garnette Sutherland
    • 1
    • 2
  • Howard Lesiuk
    • 1
    • 2
  • Ranjan Bose
    • 1
  • Anders A. F. Sima
    • 3
  1. 1.Departments of PharmacologyThe University of ManitobaWinnipegCanada
  2. 2.Departments of SurgeryThe University of ManitobaWinnipegCanada
  3. 3.Departments of PathologyThe University of ManitobaWinnipegCanada

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