Abstract
The effects of mannitol, nimodipine, and indomethacin on ischemic neuronal injury were examined in 45 rats (divided equally into nine groups) subjected to 10 min of forebrain ischemia. Of two control groups, one received maintenance fluids, while the other, a normal saline bolus. In the remaining seven groups, mannitol, nimodipine, and indomethacin were administered either singly or in combination 5 min prior to forebrain ischemia. Seven days postischemia, the brains were perfusion-fixed, sectioned coronally into 2.8-mm slices, and stained with hematoxylin and eosin. Quantification of dying neurons was performed by direct counting of standardized levels chosen from the serial sections.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ames A, Nesbett FB (1983) Pathophysiology of ischemic cell death. 1. Time of onset of irreversible damage; importance of the different components of the ischemic insult. Stroke 14:219–226
Cheung JY, Bonventre JV, Malis CD, Leaf A (1986) Calcium and ischemic injury. N Engl J Med 314:1670–1676
Dienel GA, Pulsinelli WA, Duffy TE (1980) Regional protein synthesis in rat brain following acute hemispheric ischemia. J Neurochem 35:1216–1226
Harris R, Symon L (1984) Extracellular pH, potassium and calcium activities in progressive ischaemia of rat cortex. J Cereb Blood Flow Metabol 4:178–186
Little JR (1979) Treatment of acute focal cerebral ischemia with intermittent boluses of low-dose mannitol. Neurosurgery 5(6):687–691
Shigeno S, Fritschka E, Shigeno T, Brock M (1985) Effects of indomethacin on rCBF during and after focal cerebral ischemia in the cat. Stroke 16(2):235–240
Siesjo BK (1981) Cell damage in the brain: A speculative synthesis. J Cereb Blood Flow Metabol 1:155–185
Smith M-L, Auer RN, Siesjo BK (1984) The density and distribution of ischemic brain injury in the rat following 2–10 min of forebrain ischemia. Acta Neuropathol (Berl.) 64:319–332
Steen PA, Newberg La, Milde JH, et al. (1983) Nimodipine improves cerebral blood flow and neurologic recovery after complete cerebral ischemia in the dog. J Cereb Blood Flow Metab 3:38
Symon L (1985) Flow thresholds in brain ischemia and the effects of drugs. Br J Anaesth 57:34–43
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Springer Japan
About this paper
Cite this paper
Sutherland, G., Lesiuk, H., Bose, R., Sima, A.A.F. (1988). The Effect of Mannitol, Nimodipine, and Indomethacin, Singly or in Combination, on Cerebral Ischemia. In: Suzuki, J. (eds) Advances in Surgery for Cerebral Stroke. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68314-8_115
Download citation
DOI: https://doi.org/10.1007/978-4-431-68314-8_115
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-68316-2
Online ISBN: 978-4-431-68314-8
eBook Packages: Springer Book Archive