Acute Stage Revascularization Under the Administration of a New Cerebral Protective Agent, “Sendai Cocktail”

  • Takashi Yoshimoto
  • Akira Ogawa
  • Jiro Suzuki


Following Suzuki’s discovery in 1969 that mannitol is capable of protecting the brain against the effects of ischemia [2], numerous experimental and clinical studies have been carried out in our department on substances which might have similar protective effects [3, 5, 6, 10]. Since 1980 we have been able to apply the results of that research to the treatment of ischemic vascular disorders, which had previously been treated conservatively for want of an effective therapeutic technique [4, 7]. Specifically, we currently use a new technique which entails the administration of brain protective substances at an early stage following onset. While such drugs are acting to suppress the development of pathology due to the brain ischemia, acute stage vascular reconstruction is performed. In 1982, we reported on our first series of successful cases in a preliminary study [4]. In the present paper, we discuss the results in the 52 cases experienced thus far, details of the therapeutic technique, and our current thoughts on acute stage vasculr reconstruction under the administration of cerebral protective agents.


Internal Carotid Artery Middle Cerebral Artery Cerebral Infarction Acute Stage Vascular Reconstruction 
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Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Takashi Yoshimoto
    • 1
  • Akira Ogawa
    • 1
  • Jiro Suzuki
    • 1
  1. 1.Division of Neurosurgery, Institute of Brain, DiseasesTohoku University School of MedicineSendaiJapan

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