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Acute Stage Revascularization Under the Administration of a New Cerebral Protective Agent, “Sendai Cocktail”

  • Takashi Yoshimoto
  • Akira Ogawa
  • Jiro Suzuki

Abstract

Following Suzuki’s discovery in 1969 that mannitol is capable of protecting the brain against the effects of ischemia [2], numerous experimental and clinical studies have been carried out in our department on substances which might have similar protective effects [3, 5, 6, 10]. Since 1980 we have been able to apply the results of that research to the treatment of ischemic vascular disorders, which had previously been treated conservatively for want of an effective therapeutic technique [4, 7]. Specifically, we currently use a new technique which entails the administration of brain protective substances at an early stage following onset. While such drugs are acting to suppress the development of pathology due to the brain ischemia, acute stage vascular reconstruction is performed. In 1982, we reported on our first series of successful cases in a preliminary study [4]. In the present paper, we discuss the results in the 52 cases experienced thus far, details of the therapeutic technique, and our current thoughts on acute stage vasculr reconstruction under the administration of cerebral protective agents.

Keywords

Internal Carotid Artery Middle Cerebral Artery Cerebral Infarction Acute Stage Vascular Reconstruction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Mizoi K, Yoshimoto T, Suzuki J (1981) Experimental study of new cerebral protective substances, functional recovery of severe incomplete ischemic brain lesion, pretreated with mannitol and perfluorocarbon emulsion. Acta Neurochir 56:157–161PubMedCrossRefGoogle Scholar
  2. 2.
    Suzuki J (1974) A method of prolongation of temporary stopping of the cerebral blood flow. Presidential Address, 33rd Annual Meeting JPN Neurol Surg 1974Google Scholar
  3. 3.
    Suzuki J, Yoshimoto T (1979) The effect of mannitol in prolongation of permissible occlusion time of cerebral artery—clinical data of aneurysm surgery. Neurosurg Rev 1:13–19CrossRefGoogle Scholar
  4. 4.
    Suzuki J, Yoshimoto T, Kodama N, et al. (1982) A new therapeutic method for acute brain infarction: Revascularization following the administration of mannitol and perfluorochemicals—A preliminary report. Surg Neurol 17:325–332PubMedCrossRefGoogle Scholar
  5. 5.
    Suzuki J, Fujimoto S, Mizoi K, et al. (1984) The protective effect of combined administration of antioxidants and perfluorochemicals on cerebral ischemia. Stroke 15:672–679PubMedCrossRefGoogle Scholar
  6. 6.
    Suzuki J, Imaizumi S, Kayama T, et al. (1985) Chemiluminescence in hypoxic brain. The second report: Cerebral protective effect of mannitol, vitamin E and glucocorticoid. Stroke 16:695–700PubMedCrossRefGoogle Scholar
  7. 7.
    Suzuki J, Ogawa A, Yoshimoto T, et al. (1985) Indication for surgery in the acute stage of cerebral infarction. The role of new cerebral protective drugs “Sendai cocktail” and perfluorochemicals. In: Spetzler RF, et al (eds) Cerebral revascularization for stroke. Thieme-Stratton, New York, pp 392–396Google Scholar
  8. 8.
    Suzuki J (1987) Clinical course of acute cerebral infarction—analysis from 1,000 cases. Nishimura, Niigata, pp 22–184Google Scholar
  9. 9.
    Suzuki J (1987) Treatment of cerebral infarction—experimental and clinical study. Springer, Vienna, pp 158–202CrossRefGoogle Scholar
  10. 10.
    Yoshimoto T, Sakamoto, T, Watanabe T, et al. (1978) Experimental cerebral infarction: III. Protective effect of mannitol in thalamic infarction in dogs. Stroke 9:217–218PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 1988

Authors and Affiliations

  • Takashi Yoshimoto
    • 1
  • Akira Ogawa
    • 1
  • Jiro Suzuki
    • 1
  1. 1.Division of Neurosurgery, Institute of Brain, DiseasesTohoku University School of MedicineSendaiJapan

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