Mucinous Cystic Tumors Non-Invasive and Invasive

  • Parviz M. Pour
  • Yoichi Konishi
  • Günter Klöppel
  • Daniel S. Longnecker


Of the cystic neoplasms of the pancreas, tumors composed of mucus-secreting columnar epithelium had until recently been termed cystadenoma or cystadenocarcinoma [1–3], whereas prior to this they were called by various names, including macrocystic adenoma [4], multilocular cystoma [5], and papillary cystadenocarcinoma [6].


Main Pancreatic Duct Cyst Wall Cystic Tumor Stromal Invasion Mucinous Cystic Tumor 


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  1. 1.
    Glenner GG, Mallory GK (1956) The cystadenoma and related nonfunctional tumors of the pancreas; Pathogenesis, classification, and significance. Cancer 9: 980–996PubMedCrossRefGoogle Scholar
  2. 2.
    Campbell JA, Cruickshank AH (1962) Cystadenoma and cystadenocarcinoma of the pancreas. J Clin Pathol 15: 432–437PubMedCrossRefGoogle Scholar
  3. 3.
    Becker WF, Welsh RA, Pratt HS (1965) Cystadenoma and cystadenocarcinoma of the pancreas. Ann Surg 161: 845–863PubMedCrossRefGoogle Scholar
  4. 4.
    Marziani R (1929) Fortschreitende, polyzentrische, cystisch-papillare Adenomatosis des Pankreas. Arch Anat Pathol 271: 625–638CrossRefGoogle Scholar
  5. 5.
    Fitz RH (1900) Multilocular cystoma of the pancreas. Am J Med Sci 120: 184–190CrossRefGoogle Scholar
  6. 6.
    Lichtenstein L (1934) Papillary cystadenocarcinoma of the pancreas. Am J Cancer 21: 542–553Google Scholar
  7. 7.
    Compagno J, Oertel JE (1978) Mucinous cystic neoplasms of the pancreas with overt and latent malignancy (cystadenocarcinoma and cystadenoma); A clinicopathologic study of 41 cases. Am J Clin Pathol 69: 573–580PubMedGoogle Scholar
  8. 8.
    Hodgkinson DJ, ReMine WH, Weiland LH (1978) Pancreatic cystadenoma: A clinicopathologic study of 45 cases. Arch Surg 113: 512–519PubMedCrossRefGoogle Scholar
  9. 9.
    Cantrell BB, Cubilla AL, Erlandson RA, Fortner J, Fitzgerald PJ (1981) Acinar cell cystadenocarcinoma of human pancreas. Cancer 47: 410–416PubMedCrossRefGoogle Scholar
  10. 10.
    Stamm B, Burger H, Hollinger A (1987) Acinar cell cystadenocarcinoma of the pancreas. Cancer 60: 2542–2547PubMedCrossRefGoogle Scholar
  11. 11.
    George DH, Murphy F, Michalski R, Ulmer BG (1989) Serous cystadenocarcinoma of the pancreas: A new entity?. Am J Surg Pathol 13: 61–66PubMedCrossRefGoogle Scholar
  12. 12.
    Hartmann WH, Sobin LH (eds) (1984) Atlas of tumor pathology, 2nd series, fascicle 19. Tumors of the exocrine pancreas. Armed Forces Institute of Pathology, Washington DC, pp 98–241Google Scholar
  13. 13.
    Albores-Saavedra J, Angeles-Angeles A, Nadji M, Henson DE, Alvarez L (1987) Mucinous cystadenocarcinoma of the pancreas: Morphologic and immunocytochemical observations. Am J Surg Pathol 11: 11–20PubMedCrossRefGoogle Scholar
  14. 14.
    Klöppel G (1984) Pancreatic, non-endocrine tumours. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Churchill Livingstone, Edinburgh, pp 79–113Google Scholar
  15. 15.
    Yamaguchi K, Hirakata R, Kitamura K (1990) Mucinous cystic neoplasm of the pancreas: Estimation of grade of malignancy with imaging techniques and its surgical implications. Acta Chir Scand 30. 156: 553–564Google Scholar
  16. 16.
    Morohoshi T, Kanda M, Asanuma K, Klöppel G (1989) Intraductal papillary neoplasms of the clinicopathologic study of six patients. Cancer 64: 1329–1335PubMedCrossRefGoogle Scholar
  17. 17.
    Rickaert F, Cremer M, Devière J, Tavares L, 32. Lambilliotte JP, Schröder S, Wurbs D, Klöppel G (1991) Intraductal mucin-hypersecreting neoplasms of the pancreas: A clinoco-pathologic study of eight patients. Gastroenterology 101: 512–519PubMedGoogle Scholar
  18. 18.
    Bastid C, Bernard JP, Sarles H, Payan MJ, Sahel J (1991) Mucinous ductal ectasia of the pancreas: A premalignant disease and a cause of obstructive 34. pancreatitis. Pancreas 6: 15–22PubMedCrossRefGoogle Scholar
  19. 19.
    Itai Y, Ohhashi K, Nagai H, Murakami Y, Kokubo T, Makita K, Ohtomo K (1986) “Ductectatic” mucinous cystadenoma and cystadenocarcinoma of the pancreas. Radiology 161:697–700PubMedGoogle Scholar
  20. 20.
    Dabezies MA, Campana T, Friedman AC (1990) 35. ERCP in the diagnosis of ductectatic mucinous cystadenocarcinoma of the pancreas. Gastrointest Endosc 36: 410–411PubMedCrossRefGoogle Scholar
  21. 21.
    Warshaw AL, Compton CC, Lewandrowski K,Cardenosa G, Mueller PR (1990) Cystic tumors of the pancreas: New clinical, radiologic, and pathologic observations in 67 patients. Ann Surg 212: 432–445PubMedCrossRefGoogle Scholar
  22. 22.
    Yamaguchi K, Enjoji M (1987) Cystic neoplasms of 37. the pancreas. Gastroenterology 92: 1934–1943PubMedGoogle Scholar
  23. 23.
    Warren KW, Athanassiades S, Frederick P, Kune GA (1966) Surgical treatment of pancreatic cysts: 38. Review of 183 cases. Ann Surg 163: 886–891PubMedCrossRefGoogle Scholar
  24. 24.
    Hastings PR, Nance FC, Becker WF (1975) Changing patterns in the management of pancreatic 39. pseudocysts. Ann Surg 181: 546–551PubMedCrossRefGoogle Scholar
  25. 25.
    Hodgkinson DJ, ReMine WH, Weiland LH (1978) A clinicopathologic study of 21 cases of pancreatic cystadenocarcinoma. Ann Surg 188: 679–684PubMedCrossRefGoogle Scholar
  26. 26.
    Segesser L, Rohner A (1984) Pancreatic cystadenoma and cystadenocarcinoma. Br J Surg 71: 40. 449–451CrossRefGoogle Scholar
  27. 27.
    ReMine SG, Frey D, Rossi RL, Munson JL, Braasch JW (1987) Cystic neoplasms of the pancreas. Arch Surg 122: 443–446PubMedCrossRefGoogle Scholar
  28. 28.
    Kasahara Y, Tanaka S, Miyamoto M, Morishita A,. Ueda S, Nakao K, Takemoto M, Sonobe N, Yamada Y, Kuyama T, Ueda Y, Asakawa T (1986) Cystadenoma of the pancreas: Review of the Japanese literature. Med J Kinki Univ 11: 1–9Google Scholar
  29. 29.
    Strodel WE, Eckhauser FE (1981) Cystic neoplasms of the pancreas. In: Dent TL (ed) Pancreatic disease: 42. Diagnosis and therapy. Grune and Stratton, New York, pp 363–377Google Scholar
  30. 30.
    Pour P, Krüger WF, Althoff J, Cardesa A, Mohr U (1974) Cancer of the pancreas induced in the Syrian golden hamster. Am J Pathol 76: 349–377PubMedGoogle Scholar
  31. 31.
    Friedman AC, Lichtenstein JE, Dachman AH (1983) Cystic neoplasms of the pancreas; Radiological-pathological correlation. Radiology 149: 45–50Google Scholar
  32. 32.
    Minami M, Itai Y, Ohtomo K, Yoshida H, Yoshikawa K, Iio M (1989) Cystic neoplasms of the pancreas: Comparison of MR imaging with CT. Radiology 171: 53–56PubMedGoogle Scholar
  33. 33.
    Ferrer JP, Hensley G, Kaiser MH, Zeppa R (1978) Cystadenocarcinoma and carcinoembryonic antigen ( CEA ). Cancer 42: 632–634PubMedCrossRefGoogle Scholar
  34. 34.
    Tatsuta M, Iishi H, Ichii M, Noguchi S, Yamamoto R, Yamamura H, Okuda S (1986) Values of carcinoembryonic antigen, elastase 1, and carbohydrate antigen determinant in aspirated pancreatic cystic fluid in the diagnosis of cysts of the pancreas. Cancer 57: 1836–1839PubMedCrossRefGoogle Scholar
  35. 35.
    Young NA, Villani MA, Khoury P, Naryshkin S (1991) Differential diagnosis of cystic neoplasms of the pancreas by fine-needle aspiration. Arch Pathol Lab Med 115: 571–577PubMedGoogle Scholar
  36. 36.
    Kimura K, Yamanaka T, Sakai H, Ido K, Seki H, Yoshida Y (1982) Biochemical and cytological analyses of cystic fluid aspirated by percutaneous puncture under ultrasonic guidance in cystic diseases of the pancreas. Gastroenterol Jpn 17: 4–9PubMedGoogle Scholar
  37. 37.
    Chen J, Baithun SI, Ramsay MA (1985) Histogenesis of pancreatic carcinomas: A study based on 248 cases. J Pathol 146: 65–76PubMedCrossRefGoogle Scholar
  38. 38.
    Roberts PF, Burns J (1972) A histochemical study of mucins in normal and neoplastic human pancreatic tissue. J Pathol 107: 87–94PubMedCrossRefGoogle Scholar
  39. 39.
    Bätge B, Bosslet K, Sedlacek HH, Kern HF, Klöppel G (1986) Monclonal antibodies against CEA-related components discriminate between pancreatic duct type carcinomas and non-neoplastic duct lesions as well as nonduct type neoplasias. Virchows Arch [A] 408: 361–374CrossRefGoogle Scholar
  40. 40.
    Makovitzky J (1986) The distribution and localization of the monoclonal antibody-defined antigen 19–9 (CA 19–9) in chronic pancreatitis and pancreatic carcinoma: An immunohistochemical study. Virchows Arch [B] 51: 535–544CrossRefGoogle Scholar
  41. 41.
    Ohta T, Nagakawa T, Fukushima W, Mori K, Kayahara M, Akiyama T, Kanno M, Ueno K, Miyazaki I, Terada T, Nakanuma Y (1992) Immunohistochemical study of carcinoembryonic antigen in mucinous cystc neoplasms of the pancreas. Eur Surg Res 24: 37–44PubMedCrossRefGoogle Scholar
  42. 42.
    Warren KW, Hardy KJ (1968) Cystadenocarcinoma of the pancreas. Surg Gynecol Obstet 127: 734–736PubMedGoogle Scholar

Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Parviz M. Pour
    • 1
  • Yoichi Konishi
    • 2
  • Günter Klöppel
    • 3
  • Daniel S. Longnecker
    • 4
  1. 1.The Eppley Institute for Research in Cancer; Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of Oncological Pathology, Cancer CenterNara Medical CollegeKashihara, NaraJapan
  3. 3.Department of Pathology, Academy Hospital JetteFree University of BrusselsBrusselsBelgium
  4. 4.Department of PathologyDartmouth Medical SchoolHanoverUSA

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