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Intraductal Papillary Mucinous Tumors Non-Invasive and Invasive

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Atlas of Exocrine Pancreatic Tumors

Abstract

Initial studies on premalignant lesions of pancreatic cancer showed that hyperplastic and metaplastic ductal proliferations, including papillary hyperplasia, are often found in association with pancreatic carcinoma [1, 2]. Although subsequent reports have confirmed these observations, it has been established that most of these lesions do not serve as cancer precursors [3–5]. In fact, papillary hyperplasia is now considered to be a nonspecific response of the ductal epithelium to various stimuli, especially ductal obstruction [6]. Only one case of papillary hyperplasia of the pancreas unassociated with preexisting chronic pancreatitis or pancreatic cancer has been reported [7]. Histologically, papillary hyperplasia may involve the intralobular, interlobar, and main ducts. Tall columnar mucinsecreting cells with regular basal nuclei line the papillary projections. Cytologic atypia and mitotic figures are not seen and, therefore, this lesion does not represent a diagnostic problem and should not be confused with intraductal papillary tumor.

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Author information

Authors and Affiliations

  1. The Eppley Institute for Research in Cancer; Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-6805, Omaha, NE, USA

    Parviz M. Pour M.D.

  2. Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Nara, 634, Japan

    Yoichi Konishi M.D.

  3. Department of Pathology, Academy Hospital Jette, Free University of Brussels, 1090, Brussels, Belgium

    Günter Klöppel M.D.

  4. Department of Pathology, Dartmouth Medical School, 03756, Hanover, NH, USA

    Daniel S. Longnecker M.D.

Authors
  1. Parviz M. Pour M.D.
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  2. Yoichi Konishi M.D.
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  3. Günter Klöppel M.D.
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Editor information

Editors and Affiliations

  1. The Eppley Institute for Research in Cancer; Department of Pathology and Microbiology, University of Nebraska Medical Center, 68198-6805, Omaha, NE, USA

    Parviz M. Pour M.D.

  2. Department of Oncological Pathology, Cancer Center, Nara Medical College, Kashihara, Nara, 634, Japan

    Yoichi Konishi M.D.

  3. Department of Pathology, Academy Hospital Jette, Free University of Brussels, 1090, Brussels, Belgium

    Günter Klöppel M.D.

  4. Department of Pathology, Dartmouth Medical School, 03756, Hanover, NH, USA

    Daniel S. Longnecker M.D.

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© 1994 Springer-Verlag Tokyo

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Pour, P.M., Konishi, Y., Klöppel, G., Longnecker, D.S. (1994). Intraductal Papillary Mucinous Tumors Non-Invasive and Invasive. In: Pour, P.M., Konishi, Y., Klöppel, G., Longnecker, D.S. (eds) Atlas of Exocrine Pancreatic Tumors. Springer, Tokyo. https://doi.org/10.1007/978-4-431-68311-7_4

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  • DOI: https://doi.org/10.1007/978-4-431-68311-7_4

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-68313-1

  • Online ISBN: 978-4-431-68311-7

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