Microanatomy and Fine Structure of the Pancreas

  • Parviz M. Pour
  • Yoichi Konishi
  • Günter Klöppel
  • Daniel S. Longnecker


The pancreas is the second largest gland in the digestive system and is exceeded only by the liver. It lies retroperitoneally in the upper abdominal cavity, with its head enclosed by the curve of the duodenum and its tail reaching to the spleen. Its anterior surface is covered by the peritoneum. The pancreatic parenchyma is lobulated. Each lobule is surrounded by connective tissue and is served by blood vessels and nerves. The pancreas is both an exocrine and an endocrine gland. This chapter will focus on the features of the exocrine pancreas, although the endocrine pancreas and non-parenchymal elements will be included to some extent.


Acinar Cell Pancreatic Juice Rough Endoplasmic Reticulum Main Pancreatic Duct Exocrine Pancreas 
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  1. 1.
    Heitz PU, Beglinger C, Gyr K (1984) Anatomy and physiology of the exocrine pancreas. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Churchill Livingstone, London, pp 3–21Google Scholar
  2. 2.
    Akao S, Bockman DE, Lechene de la Porte S, Sarles H (1986) Three-dimensional pattern of ductu-loacinar associations in normal and pathological human pancreas. Gastroenterology 90: 661–668Google Scholar
  3. 3.
    Morohoshi T, Kanda M, Horie A, Chott A, Dreyer T, Klöppel G, Heitz UP (1987) Immunocyto-chemical markers of uncommon pancreatic tumors. Acinar cell carcinoma, pancreatoblastoma, and solid cystic (papillary-cystic) tumor. Cancer 59: 739–747PubMedCrossRefGoogle Scholar
  4. 4.
    Morohoshi T, Sagawa F, Mitsuya T (1990) Pancreatoblastoma with marked elevation of serum alpha-fetoprotein. An autopsy case report with im-munocytochemical study. Virchows Arch [A] 416: 265–270CrossRefGoogle Scholar
  5. 5.
    Fujita H (1981) II. The cell, and III. The tissue. In: Fujita H, Fujita T (eds) Textbook of histology (in Japanese), Part I. Igaku-Shoin, Tokyo, pp 85–264Google Scholar
  6. 6.
    Kern HF (1986) Fine structure of the human exocrine pancreas. In: Go VLW, Gardener JD, Brooks FP, Lebenthal E, Di Magno E, Scheele GA (eds) The exocrine pancreas. Raven, New York, pp 9–19Google Scholar
  7. 7.
    Adler G, Bieger W, Kern HF (1978) Amino acid transport in the exocrine pancreas. Effect of maximal and supramaximal hormonal stimulation in vivo. Cell Tissue Res 194: 447–462PubMedCrossRefGoogle Scholar
  8. 8.
    Gorelick FS, Jamieson JD (1981) Structure-function relationship of the pancreas. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 773–794Google Scholar
  9. 9.
    Drenckhahn D, Mannherz HG (1983) Distribution of actin and the actin-associated proteins myosin, tropomyosin, alpha-actinin, vinculin, and villin in rat and bovine exocrine glands. Eur J Cell Biol 30: 167–176PubMedGoogle Scholar
  10. 10.
    Watanabe Y (1977) Fine structure of pancreatic acinar cell (in Japanese). Igakuno Ayumi 103: 261–270Google Scholar
  11. 11.
    Bordalo O, Baptista A, Dreiling D, Noronha M (1984) Early pathomorphological pancreatic changes in chronic alcoholism. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis—concepts and classification. Elsevier, Amsterdam, pp 57–60Google Scholar
  12. 12.
    Horie A, Morohoshi T, Klöppel G (1987) Ultra-structural comparison of pancreatoblastoma, solid-cystic tumor, and acinar cell carcinoma. J Clin Electron Microscopy 20: 353–362Google Scholar
  13. 13.
    Schulz I (1981) Electrolyte and fluid secretion in the exocrine pancreas. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 795–819Google Scholar
  14. 14.
    Case RM, Argent BE (1986) Bicarbonate secretion by pancreatic duct: Mechanisms and control. In: Go VLW, Gardner JD, Brooks RP, Lebenthal E, DiMagno E, Scheele GA (eds) The exocrine pancreas. Raven, New York, pp 213–243Google Scholar
  15. 15.
    Nagata A, Monno S (1984) Ultrastructure of pancreatic duct and pancreatic ductal cells (in Japanese). The Cell 16: 397–402Google Scholar
  16. 16.
    Bockman DE, Büchler M, Beger HG (1986) Structure and function of specialized cilia in the exocrine pancreas. Int J Pancreatol 1: 21–28PubMedGoogle Scholar
  17. 17.
    Churg A, Richter WR (1972) Histochemical distribution of carbonic anhydrase after ligation of the pancreatic duct. Am J Pathol 68: 23–30PubMedGoogle Scholar
  18. 18.
    Spicer SS, Sens MA, Tashian RE (1982) Immuno-cytochemical demonstration of carbonic anhydrase in human epithelial cells. J Histochem Cytochem 30: 864–873PubMedCrossRefGoogle Scholar
  19. 19.
    Klöppel G (1984) Anatomy and physiology of the endocrine pancreas. In: Klöppel G, Heitz PU (eds) Pancreatic pathology. Churchill Livingstone, London, pp 133–153Google Scholar
  20. 20.
    Bockman DE (1992) Microvasculature of the pancreas: Relation to pancreatitis. Int J Pancreatol 12: 11–21PubMedGoogle Scholar
  21. 21.
    Bockman DE, Büchler M, Malfertheiner P, Beger HG (1988) Analysis of nerves in chronic pancreatitis. Gastroenterology 94: 1459–1469PubMedGoogle Scholar
  22. 22.
    Watari N (1984) Ultrastructural studies on the connective tissues in the pancreas (in Japanese). The Cell 16: 402–408Google Scholar
  23. 23.
    Morohoshi T, Kanda M (1985) Periacinar fibro-blastoid cell—its action on early stage of alcoholic pancreatitis (in Japanese). Tann to Sui 6: 1205–1211Google Scholar
  24. 24.
    Bockman DE (1993) Surgical anatomy of the pancreas and adjacent structures. In: Beger HG, Büchler M, Malfertheiner P (eds) Standards in pancreatic surgery. Springer, Berlin Heidelberg New York (in press)Google Scholar

Copyright information

© Springer-Verlag Tokyo 1994

Authors and Affiliations

  • Parviz M. Pour
    • 1
  • Yoichi Konishi
    • 2
  • Günter Klöppel
    • 3
  • Daniel S. Longnecker
    • 4
  1. 1.The Eppley Institute for Research in Cancer; Department of Pathology and MicrobiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of Oncological Pathology, Cancer CenterNara Medical CollegeKashihara, NaraJapan
  3. 3.Department of Pathology, Academy Hospital JetteFree University of BrusselsBrusselsBelgium
  4. 4.Department of PathologyDartmouth Medical SchoolHanoverUSA

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